ID A7STV5_NEMVE Unreviewed; 460 AA.
AC A7STV5;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=TNF receptor-associated factor 4 {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEMVEDRAFT_v1g217424 {ECO:0000313|EMBL:EDO32851.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO32851.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO32851.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; DS469803; EDO32851.1; -; Genomic_DNA.
DR RefSeq; XP_001624951.1; XM_001624901.1.
DR AlphaFoldDB; A7STV5; -.
DR STRING; 45351.A7STV5; -.
DR EnsemblMetazoa; EDO32851; EDO32851; NEMVEDRAFT_v1g217424.
DR eggNOG; KOG0297; Eukaryota.
DR HOGENOM; CLU_021061_4_1_1; -.
DR InParanoid; A7STV5; -.
DR OMA; PCPNGCK; -.
DR PhylomeDB; A7STV5; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0070534; P:protein K63-linked ubiquitination; IBA:GO_Central.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IBA:GO_Central.
DR CDD; cd00270; MATH_TRAF_C; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF151; TNF RECEPTOR ASSOCIATED FACTOR (TRAF) HOMOLOG; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR Pfam; PF02176; zf-TRAF; 2.
DR PIRSF; PIRSF015614; TRAF; 2.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 3.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00207}; Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00207};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT DOMAIN 45..83
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 127..170
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 182..236
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 301..452
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT ZN_FING 127..170
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT ZN_FING 182..236
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
SQ SEQUENCE 460 AA; 52265 MW; B8B089CEBCFEC20C CRC64;
MTGGQSPTGS TQSCGSNGLR DSPVEKGHLP ASNLFVYPLQ KKYICLDCEG LLWYPVQIKP
CGHRVCTKCY TKLLSSSARC PGCMDELNEN IPDIDKAFHE EIQELDVKCR NVEWNCKWEG
CVNEFSSHVE KCDYSDILCE NDCGAKFQRR FLTKHLDKDC PEKLITCLYC DEKHLRKDKK
GHLENCPLLP CPCPNKCDKK LTIHRCELDS HVENDCPRTK LMCEYEVLGC GHRITGLEGG
GSREKMPKHN KTNIIAHVKM VADLALKNKE LIMRFSEKLS EHGTLIEKHE KRLNDLEKIA
HSQLIWRIED YTRKMKEAKA GNTDTLFSPT FTTSKHGYRL CASVCLNGDG KGKGTHMSVF
ISVLKGAFDA LLKWPFDYRV TFVLLDQNDD PAQRKHIRFS IKPNPCADNE PFLGRPRLEK
NASFGGAKFA KHEEIVSRNY IKEDTIFLKI SVDCDGLSEP
//
