ID A7SVB1_NEMVE Unreviewed; 219 AA.
AC A7SVB1;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=HECT domain-containing protein {ECO:0000259|PROSITE:PS50237};
GN ORFNames=NEMVEDRAFT_v1g133891 {ECO:0000313|EMBL:EDO32366.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO32366.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO32366.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
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DR EMBL; DS469829; EDO32366.1; -; Genomic_DNA.
DR RefSeq; XP_001624466.1; XM_001624416.1.
DR AlphaFoldDB; A7SVB1; -.
DR STRING; 45351.A7SVB1; -.
DR EnsemblMetazoa; EDO32366; EDO32366; NEMVEDRAFT_v1g133891.
DR KEGG; nve:5503374; -.
DR eggNOG; KOG1426; Eukaryota.
DR HOGENOM; CLU_002173_4_2_1; -.
DR InParanoid; A7SVB1; -.
DR OMA; MAGSEEY; -.
DR PhylomeDB; A7SVB1; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042469; HECTD3.
DR PANTHER; PTHR46654; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR PANTHER; PTHR46654:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 44..219
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 195
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDO32366.1"
SQ SEQUENCE 219 AA; 25186 MW; 3B57431B3025757D CRC64;
MAGCNGVSHP PQDYVPGLMC IRDMDAAALE AMDMPFSTPS ASGREMRLHA KMKTICQENR
EEYVRLALNH RLHEFDQQCS AVREGMGRVV PVPFLSLFTG PELETMVCGS PDIPLDLLKS
VVTYKGIDGN APLVRWFWDT LESFSNAERS LFLRFVWGRT RLPRTIADFR GRDFVFQVLD
KYNPPDHYLP ESYTCFFLLK MPRYSSHRIL CEKLKYAVH
//
