ID A7T225_NEMVE Unreviewed; 283 AA.
AC A7T225;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Fucolectin tachylectin-4 pentraxin-1 domain-containing protein {ECO:0000259|SMART:SM00607};
GN ORFNames=NEMVEDRAFT_v1g221173 {ECO:0000313|EMBL:EDO29994.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO29994.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO29994.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- FUNCTION: Acts as a defensive agent. Recognizes blood group fucosylated
CC oligosaccharides including A, B, H and Lewis B-type antigens. Does not
CC recognize Lewis A antigen and has low affinity for monovalent haptens.
CC {ECO:0000256|ARBA:ARBA00002219}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SIMILARITY: Belongs to the fucolectin family.
CC {ECO:0000256|ARBA:ARBA00010147}.
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DR EMBL; DS470189; EDO29994.1; -; Genomic_DNA.
DR RefSeq; XP_001622094.1; XM_001622044.1.
DR AlphaFoldDB; A7T225; -.
DR EnsemblMetazoa; EDO29994; EDO29994; NEMVEDRAFT_v1g221173.
DR eggNOG; ENOG502SE8Y; Eukaryota.
DR HOGENOM; CLU_984498_0_0_1; -.
DR InParanoid; A7T225; -.
DR PhylomeDB; A7T225; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0042806; F:fucose binding; IEA:UniProt.
DR GO; GO:0010185; P:regulation of cellular defense response; IEA:UniProt.
DR GO; GO:0001868; P:regulation of complement activation, lectin pathway; IEA:UniProt.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR006585; FTP1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR45713:SF6; F5_8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45713; FTP DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR SMART; SM00607; FTP; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..283
FT /note="Fucolectin tachylectin-4 pentraxin-1 domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002715407"
FT DOMAIN 139..282
FT /note="Fucolectin tachylectin-4 pentraxin-1"
FT /evidence="ECO:0000259|SMART:SM00607"
SQ SEQUENCE 283 AA; 30804 MW; BD0D5E94F21E7024 CRC64;
MKSVEKLSLG LLLLGGVFYG TEVEVGAKTT TKETCVVVHN YYGASHENSI TALLSSIQEK
ITKQTTKLQA LKVSQEKGIK KLYSLLSAIK TQLESNCAKG RSHGPAHLLF PKYIQANIRI
LASKQSSKEP LQATHQHDQH CSAQASVQSS LYHQEGVASH AVDGNRDGNY GNWSCTHTNA
ETNPWWRVDL GASHRVAQVF IVARSDCCGD KQELRNIVIH VGDSLANNGN TNARCGGAYT
IPQGKNLTIT CSPALQGRYV SIMLPGAKQI LTLCEVEVYP CNQ
//
