ID A7TII5_VANPO Unreviewed; 246 AA.
AC A7TII5;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDO17923.1};
GN ORFNames=Kpol_1010p39 {ECO:0000313|EMBL:EDO17923.1};
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN [1] {ECO:0000313|EMBL:EDO17923.1, ECO:0000313|Proteomes:UP000000267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the RNase PH family.
CC {ECO:0000256|ARBA:ARBA00006678}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS480396; EDO17923.1; -; Genomic_DNA.
DR RefSeq; XP_001645781.1; XM_001645731.1.
DR AlphaFoldDB; A7TII5; -.
DR STRING; 436907.A7TII5; -.
DR GeneID; 5546179; -.
DR KEGG; vpo:Kpol_1010p39; -.
DR eggNOG; KOG1068; Eukaryota.
DR HOGENOM; CLU_063514_0_1_1; -.
DR InParanoid; A7TII5; -.
DR OMA; ECRINTH; -.
DR OrthoDB; 202892at2759; -.
DR PhylomeDB; A7TII5; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IEA:UniProt.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:UniProt.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProt.
DR GO; GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IEA:UniProt.
DR GO; GO:0016075; P:rRNA catabolic process; IEA:UniProt.
DR CDD; cd11370; RNase_PH_RRP41; 1.
DR Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR015847; ExoRNase_PH_dom2.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR11953; EXOSOME COMPLEX COMPONENT; 1.
DR PANTHER; PTHR11953:SF0; EXOSOME COMPLEX COMPONENT RRP41; 1.
DR Pfam; PF01138; RNase_PH; 1.
DR Pfam; PF03725; RNase_PH_C; 1.
DR SUPFAM; SSF55666; Ribonuclease PH domain 2-like; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000000267};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 21..152
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF01138"
FT DOMAIN 156..219
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF03725"
SQ SEQUENCE 246 AA; 27466 MW; 1CE23445B827497D CRC64;
MSRFELYSPE GLRLDGRRWN ELRRFECSIN THAHASDGSS YLEQGNNKIV TLVKGPQEPI
LRSQLDATKA SLNITVNITK FSKMERSKSS HKNERRVLEM QTALVRTFEK NVMLHLYPRT
LIDIEIHVLQ QDGGILGSLI NSITLALIDS GIAMYDYVSA ISIGLYDTTP LLDVNTLEEN
AMSTVTLGVI GKSEKLSLLS VEDKIPLDRL ESVLAIGIAG AHRVRELMDN ELRKHAAHRV
AKSSAK
//
