GenomeNet

Database: UniProt
Entry: A7TK36_VANPO
LinkDB: A7TK36_VANPO
Original site: A7TK36_VANPO 
ID   A7TK36_VANPO            Unreviewed;       405 AA.
AC   A7TK36;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   03-MAY-2023, entry version 74.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDO17382.1};
GN   ORFNames=Kpol_1060p38 {ECO:0000313|EMBL:EDO17382.1};
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN   [1] {ECO:0000313|EMBL:EDO17382.1, ECO:0000313|Proteomes:UP000000267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC   NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00007317}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS480405; EDO17382.1; -; Genomic_DNA.
DR   RefSeq; XP_001645240.1; XM_001645190.1.
DR   AlphaFoldDB; A7TK36; -.
DR   STRING; 436907.A7TK36; -.
DR   GeneID; 5545599; -.
DR   KEGG; vpo:Kpol_1060p38; -.
DR   eggNOG; KOG0557; Eukaryota.
DR   HOGENOM; CLU_035825_2_1_1; -.
DR   InParanoid; A7TK36; -.
DR   OMA; NRFEVYD; -.
DR   OrthoDB; 52212at2759; -.
DR   PhylomeDB; A7TK36; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0045254; C:pyruvate dehydrogenase complex; IEA:InterPro.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   GO; GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IEA:InterPro.
DR   CDD; cd06849; lipoyl_domain; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 4.10.320.10; E3-binding domain; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR045257; E2/Pdx1.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   PANTHER; PTHR23151; DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR23151:SF82; PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   SUPFAM; SSF51230; Single hybrid motif; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Lipoyl {ECO:0000256|ARBA:ARBA00022823};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000267};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          29..105
FT                   /note="Lipoyl-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50968"
FT   DOMAIN          167..208
FT                   /note="Peripheral subunit-binding (PSBD)"
FT                   /evidence="ECO:0000259|PROSITE:PS51826"
FT   REGION          123..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..160
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   405 AA;  44795 MW;  7D09FC1D0E8E9FA1 CRC64;
     MLRFGASRNI LLRRLSFRKF GTSLRLFDAN AFAMPAMSPT MEKGGIVQWK FKVGEPFSAG
     DVLLEVETDK AQIDVEAQDD GKIAKIIIGD GAKDVPVGDT IAFLAEVDDD LSTLKIPDVT
     AAPKKDAAPK TEPLSKPISK PVENPTEVRS NETVSSAATK SADMKQVLLP SVAIELSLNG
     IKKEDALKNI KATGTKGRLL KGDVLAYVGK INKDSPSKIA SYIEKGEKLD LSNIELREPA
     VQETKESTSK ESTKMVKEPI ILNEYIALRA KPGASLEKLE LALGQYLDSM FQKAHNDTLV
     DTRSQFYDPI FEDLLSIESN KPRFTLSYEL IELENEDIPS RRSRASEADI FDLLSNETPA
     SQVNEKSNNN ATEFVVSLRV EVNDKYPDSM ERAQKFVSYM KQLQL
//
DBGET integrated database retrieval system