ID A7TK86_VANPO Unreviewed; 311 AA.
AC A7TK86;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=NADP-dependent oxidoreductase domain-containing protein {ECO:0000259|Pfam:PF00248};
GN ORFNames=Kpol_1062p29 {ECO:0000313|EMBL:EDO17321.1};
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN [1] {ECO:0000313|EMBL:EDO17321.1, ECO:0000313|Proteomes:UP000000267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
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DR EMBL; DS480406; EDO17321.1; -; Genomic_DNA.
DR RefSeq; XP_001645179.1; XM_001645129.1.
DR AlphaFoldDB; A7TK86; -.
DR STRING; 436907.A7TK86; -.
DR GeneID; 5545529; -.
DR KEGG; vpo:Kpol_1062p29; -.
DR eggNOG; KOG1577; Eukaryota.
DR HOGENOM; CLU_023205_0_0_1; -.
DR InParanoid; A7TK86; -.
DR OMA; CNFHEPE; -.
DR OrthoDB; 5305445at2759; -.
DR PhylomeDB; A7TK86; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR PANTHER; PTHR11732:SF504; GLYCEROL 2-DEHYDROGENASE (NADP(+))-RELATED; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000267}.
FT DOMAIN 21..291
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 54
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 110
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 79
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 311 AA; 34229 MW; E79B4A0E5C6D0631 CRC64;
MSLKNCETRV KLNTGAELPA VGLGTWQSLE NDAYKAVLTA LKTGYRHIDG AAIYCNEGEV
GKAIRDSGVP RNEIFVTTKL WGTQQRTPQL ALEQSLERLG LDYVDLYLIH WPIPLNPAQC
EESGNYLTFP GLPNGKRDVD LDTWNFVKTW ELMQELPATG KCKAVGVSNF SINNIKELLS
SPGNKLVPAV NQIELHPLLP QVELVNFCKE KGIVVEAYSP LGGTGAAILK EPLVEELAKK
YNIPAANLVV SWDVQRGVVV LPKSVTESRI ISNLQTLTLA PEDVEKITNL SKEKGEKRTC
APDFSPFNTF A
//
