ID A7TZR7_9VIRU Unreviewed; 1977 AA.
AC A7TZR7;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Replicase {ECO:0000313|EMBL:ABS89245.1};
OS Coleus vein necrosis virus.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Tymovirales; Betaflexiviridae; Quinvirinae; Carlavirus.
OX NCBI_TaxID=404404 {ECO:0000313|EMBL:ABS89245.1, ECO:0000313|Proteomes:UP000203903};
RN [1] {ECO:0000313|EMBL:ABS89245.1, ECO:0000313|Proteomes:UP000203903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=18094923; DOI=10.1007/s00705-007-1068-0;
RA Kraus J., Tzanetakis I.E., Putnam M.L., Martin R.R.;
RT "Complete nucleotide sequence of an isolate of coleus vein necrosis virus
RT from verbena.";
RL Arch. Virol. 153:381-384(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the potexviruses/carlaviruses RNA replication
CC protein family. {ECO:0000256|ARBA:ARBA00008513}.
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DR EMBL; EF527260; ABS89245.1; -; Genomic_RNA.
DR RefSeq; YP_001430021.1; NC_009764.1.
DR GeneID; 5536816; -.
DR KEGG; vg:5536816; -.
DR Proteomes; UP000203903; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016817; F:hydrolase activity, acting on acid anhydrides; IEA:InterPro.
DR GO; GO:0008174; F:mRNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23245; Betaflexiviridae_RdRp; 1.
DR CDD; cd22792; OTU_RDRP-like; 1.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR002588; Alphavirus-like_MT_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR003323; OTU_dom.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008041; Peptidase_C23.
DR InterPro; IPR001788; RNA-dep_RNA_pol_alsuvir.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF05379; Peptidase_C23; 1.
DR Pfam; PF00978; RdRP_2; 1.
DR Pfam; PF01443; Viral_helicase1; 1.
DR Pfam; PF01660; Vmethyltransf; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51743; ALPHAVIRUS_MT; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
DR PROSITE; PS50802; OTU; 1.
DR PROSITE; PS51492; PEPTIDASE_C23; 1.
DR PROSITE; PS51657; PSRV_HELICASE; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000203903};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 63..254
FT /note="Alphavirus-like MT"
FT /evidence="ECO:0000259|PROSITE:PS51743"
FT DOMAIN 748..839
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT DOMAIN 895..1004
FT /note="OTU"
FT /evidence="ECO:0000259|PROSITE:PS50802"
FT DOMAIN 1003..1093
FT /note="Peptidase C23"
FT /evidence="ECO:0000259|PROSITE:PS51492"
FT DOMAIN 1153..1463
FT /note="(+)RNA virus helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51657"
FT DOMAIN 1755..1862
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT REGION 842..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1977 AA; 221460 MW; 5DD5B49D6BE4D6E9 CRC64;
MALTFRSPLE EVLTNFSSTE QSLISKTAIN HYSNLESSLF NFFNLNVDAY SKEKLINSGI
YLSPFSGVPH SHPVCKTLEN HILYRVLPSL IDSTFTFVGI KEAKLQFLRQ RHSHLNLVQL
INRYVTSADR LRYPSEFHIT PSKAIEVCEK WGRFGKSDSL RELLPACITH KPRALFLHDE
LHYWNLKELK VFLLAVKPEK LLGTLVFPPE LLQGVHESLN PWCYTFEVDD KWLHYYPDGV
KTEGYTQPRN SGYLLRLSKI HLSDGSTYCV DLVYSCYSHH IIALTLGDAV RKPFNAFSGF
DATTFQGLKK LDLRGIGPCL PISFSVVNRI YRYLRTLQKP DLASAMAKLS QILPEPTSFQ
IKFIREFSEL VIKTETCSNL FQNNVLLDIK NFFASQLPKR LAATVDAYKI SSLDEFLEKM
EPYSFTIKLV EATALMDIIF NFDRDIEGFE HEVDIVAELE AFANPKNPHA HNAKTTPYFC
EPYCDAVEFC VQKMAKLVLV KAAGLLYHGM PVMGGHQAHD IFLDVARRIP LVDYCCGFGL
EEEIRLVFIE KFIGLVRKHS RSNVLEIPTG LDWFMFPRRR NVFYLTCTPE AIVATKLMRG
MWDNVVNELA ASSALIKRIG ITLSDRNTPV APLEVVLPPA PEPIKQEGSN GSVGVSNELA
EDAIANFTPP AFIRNFSCSC GLEMPISSVV GGDFVYFDLP DVLPGRRAAW FTKDGSTAYT
YKGGKHASMG WDERLDLLLE IHGFEGSLFD SALVQEYEQG ARIGFHSDDE SIFKVGSEIL
TMQLKGTSRF AIQGSRCYGS SALLGGCHFT MPAGFQETHK HSVAECSSGR TSITFRVLKG
TEQPSAPLHP TNEKVEPGGG AVSSRLGAPE ELSAFDYQIG PVRVENVGGP RAGSYTLTDV
PGDGSCFFHA VGLSFNLTGL ALRRALLDAA PEIGGMFPAE AFAELRGGGA VSDVCVCYVA
HALKSSIAVI SHHEGCMRVF CPDNWENKID LLHKDGHYNV VNYKNDCALL AVAETLGRTK
REVTEVVCKA KHGGLLRSMR TGEGLKVELL GELFKIFSIK ALVKCNGQLH RLNPEGKILG
HYRLEDGHIQ VDKGLIKQLG SAPVKVIEHP VHGSGMVLIA AVATQLSFEI NAEIGDKLAE
CLVSGRTGVI SSQLFNGRQK LTIPAGSDGK SRAVNLITGV FGCGKSTLMK RSFESGLGSK
CYFVTPRRSL ADIFSDELTS GRIKTKTTVV VQTYEKFLRM LESVEPRDVV IFDEMQLFPH
GYFDLTFSIM SQEVPTVCLG DLCQSDYDCA TDRSELGCYQ SDMQRLLQSA KYTYYTRSHR
FQNSNFAGRL PCQFQPEYFT NHEDFTILHG FESLNDIAGL DCILVSSFNE KTAVKALTFG
RVSVQTFGES TGLTFNSGAI FISEVSKLAS EQRWLTALSR FRMNLTFVSD LGCDSSMLAE
VFSGRVLGRF LSGKANVCDL RGLLAGSPDL QEDFPTTVGK NQGLVEEKVV GDPWLKAMLF
LGQETDEQEV APEVAEVALE VFKTHAPRCE LEGVRARWHE KIQAKEFREK RMGYLVSEQF
TDEHSKNNGK KLTNAAERFE TIYPKHKNSD TVTFIMGARK RLRFSKPLVE ARKLQDAKVY
GEFMLQNFPK YVPLRKQHNK GFMDKALRDF ESKKVSKSAA IIANHAGRSC RDWLADVGLV
FMKSQHCTKF DNRFRDAKAA QSIVCFQHAV LCRFAPYMRY IEMKLQEVLP SNFYVHSGKG
LDELSEWVKK GKFEGICTES DYEAFDASQD QYIMAFELKV MEYLGIPKDL IADYVYIKTH
LGSKLGNFAI MRYSGEASTF LFNTMANMLF TFLRYDVKGN EFICFAGDDM CANTKLRKVD
THESFLSKLK LKAKVGFVNK PTFCGWNLCS DGIYKKPQLV LERLCIAKET NNLTSCIDNY
AIEVSYAYRM SEKATMRMSE EELDSHYNCL RIIIKNKHLM KSEAANIFKA SDVGLGI
//
