ID A7UEC0_CTEID Unreviewed; 161 AA.
AC A7UEC0;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=IGF1 {ECO:0000313|EMBL:AGW17294.1};
DE SubName: Full=Insulin-like growth factor I {ECO:0000313|EMBL:ABU40947.1};
GN Name=igf1 {ECO:0000313|EMBL:AGW17294.1};
OS Ctenopharyngodon idella (Grass carp) (Leuciscus idella).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Xenocyprididae; Xenocypridinae; Ctenopharyngodon.
OX NCBI_TaxID=7959 {ECO:0000313|EMBL:ABU40947.1};
RN [1] {ECO:0000313|EMBL:ABU40947.1}
RP NUCLEOTIDE SEQUENCE.
RA Brown G.F., Wong A.O.L.;
RT "Molecular cloning, tissue distribution and functional characterization of
RT IGF-1 in Chinese grass carp.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGW17294.1}
RP NUCLEOTIDE SEQUENCE.
RA Wong W.W., Wong A.O.L.;
RT "Genomic organization of grass carp igf1 gene.";
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EU051323; ABU40947.1; -; mRNA.
DR EMBL; KF199853; AGW17294.1; -; Genomic_DNA.
DR AlphaFoldDB; A7UEC0; -.
DR SMR; A7UEC0; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04368; IlGF; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022341; IGF-I.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR022350; Insulin-like_growth_factor.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46845:SF3; INSULIN-LIKE GROWTH FACTOR 1; 1.
DR PANTHER; PTHR46845; INSULIN-LIKE GROWTH FACTOR I; 1.
DR Pfam; PF00049; Insulin; 2.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02005; INSLNLIKEGF1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR622350-50};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..44
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 45..161
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007636526"
FT DOMAIN 47..105
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 127..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 50..92
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 62..105
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 91..96
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
SQ SEQUENCE 161 AA; 17909 MW; A70327B1908120D8 CRC64;
MSSGHFFQGH WCDVFKCTMR CLSCTHTLSL VLCVLALTPA TLEAGPETLC GAELVDTLQF
VCGDRGFYFS KPTGYGPSSR RSHNRGIVDE CCFQSCELRR LEMYCAPVKT GKSPRSLRAQ
RHTDITRTAK KPISGHSHSS CKEVHQKNSS RGNTGGRNYR M
//
