ID   A7VBM5_9CLOT            Unreviewed;      1408 AA.
AC   A7VBM5;
DT   23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Putative CoA-substrate-specific enzyme activase {ECO:0000313|EMBL:EDO59228.1};
GN   ORFNames=CLOL250_00287 {ECO:0000313|EMBL:EDO59228.1};
OS   Clostridium sp. L2-50.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=411489 {ECO:0000313|EMBL:EDO59228.1, ECO:0000313|Proteomes:UP000003352};
RN   [1] {ECO:0000313|EMBL:EDO59228.1, ECO:0000313|Proteomes:UP000003352}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L2-50 {ECO:0000313|EMBL:EDO59228.1,
RC   ECO:0000313|Proteomes:UP000003352};
RA   Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA   Gordon J.;
RT   "Draft genome sequence of Clostridium sp. L2-50.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EDO59228.1, ECO:0000313|Proteomes:UP000003352}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L2-50 {ECO:0000313|EMBL:EDO59228.1,
RC   ECO:0000313|Proteomes:UP000003352};
RA   Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA   Thiruvilangam P., Bhonagiri V., Nash W.E., Hodges J., Shah N., Mardis E.R.,
RA   Wilson R.K.;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDO59228.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAYW02000002; EDO59228.1; -; Genomic_DNA.
DR   eggNOG; COG1924; Bacteria.
DR   eggNOG; COG3580; Bacteria.
DR   eggNOG; COG3581; Bacteria.
DR   HOGENOM; CLU_002393_1_0_9; -.
DR   Proteomes; UP000003352; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.40; -; 4.
DR   InterPro; IPR002731; ATPase_BadF.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018709; CoA_activase_DUF2229.
DR   InterPro; IPR008275; CoA_E_activase_dom.
DR   NCBIfam; TIGR00241; CoA_E_activ; 1.
DR   PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR   PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR   Pfam; PF01869; BcrAD_BadFG; 2.
DR   Pfam; PF09989; DUF2229; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023014};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00023014}.
FT   DOMAIN          7..255
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          321..575
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          671..890
FT                   /note="DUF2229"
FT                   /evidence="ECO:0000259|Pfam:PF09989"
SQ   SEQUENCE   1408 AA;  154615 MW;  2B9B1C9A9ACA80CC CRC64;
     MVFMYKLGID IGSTTVKVVV LDDSHKILFS DYRRHYANIK ETLQSLINDA KARLGDVEVT
     PAITGSGGLA LAEVIGVPFT QEVVCVSEAL QDYAPQTDVA IELGGEDAKI IYFTNGIEQR
     MNGVCAGGTG SFIDQMATLL QTDASGLNEY AKDYDTIYPI AARCGVFAKT DIQPLINEGA
     TKPNLAASIF QAVVNQTISG LACGKPIKGN VAFLGGPLHF LPELKNAFIR TLNLTGDAII
     DPGHSHLFAA TGAALNSKPE VSRTLGELSH SLDGELHMAE NVLRLPPLFE DEAAYEAFKE
     EHNKYKVKRG DLATYKGNCF IGVDAGSTTT KVALVGSNGE LLYDFYSSNN GSPLNTTIKA
     IKDIYSKLPE GAVIAGSCST GYGEALIKQA LSLDFGEVET IAHYTAAAFF DPEVDCILDI
     GGQDMKCIKI KNKVVDNVML NEACSSGCGS FIETFAKSLN YDIADFAKIA TTAKTPIDLG
     SRCTVFMNSK VKQAQKEGAS VADISAGLAY SVIKNALLKV IKLTDPKDLG KNIVVQGGTF
     YNDAVLKSFE VISGRTAIRP DISGIMGAFG AALIAMNKYK EGFKTSMLSI DEISKLTYTT
     NMTRCKGCTN NCLLTINRFS NGKNFITGNR CEKGVGLKKN ADNIPNLFEY KLNRIFDYTP
     LTPDMAKRGV IGIPRVLNMY ENYPFWFTFL TKLGFSVVLS PKSSRDIYSL GIESIPSESE
     CYPAKISHGH VMWLLKNGIT SIFYPCVPYE MNETPEANNH YNCPIVTSYA ENIKNNMEEL
     KDDKITFIRP FVALDNEQAL VDRMYREMKK YYDVTTDEIA SAVRAAYEEA EKVKTDIREK
     GEETLRYIDE HDILGIVLAG RPYHIDPEIN HGLPELINSY KIAVLTEDSV AHLGQVDRPL
     IVSDQWMYHS RLYKAANYVK TCDNLELIQL NSFGCGLDAV TTDCVNDILT KSGKIYTVLK
     IDEVSNLGAA RIRIRSLISA VNSRKEQNYK TCPSSSAINR IEFTKDMMKD YTVLAPQMSP
     IHFNLLESAF KVMGLNIEIL PDATKETIDV GLKYVNNDAC YPSLIVVGQL MSAITSGKYD
     VNKLAVIMSQ TGGGCRATNY VGFIRRALAK AGYGQIPVIA LSAQGFEKNS GFPITLKLAK
     RAIQALVYGD VFMRCLYHTR PYEKEPGSAN AIHKKWEKIC KKTLEETGST ARFKKNINGI
     VHDFDTLPLL DIKKPRVGIV GEILVKFLPS ANNHLVDLLE SEGAEAVMPD LLDFFMYCFY
     NSNYKYEYLG KTHKGAIIGN AAISLLEHMR KPATDALKAS KRFDPPTPIT HLAEYARPFV
     SIGNQTGEGW FLTGEMIELI NSGAANIVCA QPFACLPNHI VGKGVIKHLR EAYPDANIVA
     VDYDPGASEV NQINRIKLML AAANKKLK
//