ID A7XW10_9HIV1 Unreviewed; 243 AA.
AC A7XW10;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:ABU87342.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ABU87342.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ABU87342.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ABU87342.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17876005; DOI=10.1128/AAC.00687-07;
RA Bradshaw D., Malik S., Booth C., Van Houtte M., Pattery T., Waters A.,
RA Ainsworth J., Geretti A.M.;
RT "Novel drug resistance pattern associated with the mutations K70G and M184V
RT in human immunodeficiency virus type 1 reverse transcriptase.";
RL Antimicrob. Agents Chemother. 51:4489-4491(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
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DR EMBL; EU099982; ABU87342.1; -; Genomic_RNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR33064; POL PROTEIN; 1.
DR PANTHER; PTHR33064:SF35; RIBONUCLEASE H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW ECO:0000313|EMBL:ABU87342.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 44..234
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABU87342.1"
FT NON_TER 243
FT /evidence="ECO:0000313|EMBL:ABU87342.1"
SQ SEQUENCE 243 AA; 28115 MW; 84AEB169A7503119 CRC64;
PISPIETVPV KLKPGMDGPK VKQWPLTEEK IKALTEICTE MEKEGKISKI GPENPYNTPI
FAIKKKDSTG WRKLVDFREL NKRTQDFWEV QLGIPHPAGL KKKKSVTVLD VGDAYFSVPL
DEDFRKYTAF TIPSVNNETP GVRYQYNVLP QGWKGSPAIF QCSMTKILEP FRTKNPEMVI
YQYVDDLYVG SDLEIGQHRA KIEELREHLL KWGFTTPDKK HQKEPPFLWM GYELHPDKWT
VQP
//