ID A7YL29_9INFA Unreviewed; 369 AA.
AC A7YL29;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00020035};
DE EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
DE Flags: Fragment;
GN Name=PB1 {ECO:0000313|EMBL:ABL61457.1};
OS Influenza A virus(A/swine/Henan/4/2004(H9N2)).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus;
OC Alphainfluenzavirus influenzae; Influenza A virus.
OX NCBI_TaxID=415168 {ECO:0000313|EMBL:ABL61457.1};
RN [1] {ECO:0000313|EMBL:ABL61457.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A/swine/Henan/4/2004 {ECO:0000313|EMBL:ABL61457.1};
RA Cong Y., Liu J.;
RT "Isolation and Characterization of H9N2 Swine Influenza Reassortant Viruses
RT in China During 2003-2004.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABL61457.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A/swine/Henan/4/2004 {ECO:0000313|EMBL:ABL61457.1};
RX PubMed=18401696; DOI=10.1007/s11262-008-0227-z;
RA Cong Y.L., Wang C.F., Yan C.M., Peng J.S., Jiang Z.L., Liu J.H.;
RT "Swine infection with H9N2 influenza viruses in China in 2004.";
RL Virus Genes 36:461-469(2008).
CC -!- FUNCTION: RNA-dependent RNA polymerase which is responsible for
CC replication and transcription of virus RNA segments. The transcription
CC of viral mRNAs occurs by a unique mechanism called cap-snatching. 5'
CC methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides
CC by PA. In turn, these short capped RNAs are used as primers by PB1 for
CC transcription of viral mRNAs. During virus replication, PB1 initiates
CC RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn
CC serves as a template for the production of more vRNAs.
CC {ECO:0000256|ARBA:ARBA00002148}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus
CC {ECO:0000256|ARBA:ARBA00004147}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; DQ981544; ABL61457.1; -; Viral_cRNA.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0039523; P:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019083; P:viral transcription; IEA:UniProtKB-KW.
DR InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR InterPro; IPR001407; RNA_pol_PB1_influenza.
DR Pfam; PF00602; Flu_PB1; 1.
DR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE 4: Predicted;
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Eukaryotic host transcription shutoff by virus
KW {ECO:0000256|ARBA:ARBA00022731};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host RNA polymerase II by virus
KW {ECO:0000256|ARBA:ARBA00023103};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022484};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Viral transcription {ECO:0000256|ARBA:ARBA00023314}.
FT DOMAIN 59..256
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50525"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABL61457.1"
FT NON_TER 369
FT /evidence="ECO:0000313|EMBL:ABL61457.1"
SQ SEQUENCE 369 AA; 41869 MW; 9348A00DC83470FF CRC64;
TKDAERGKLK RRAIATPGMQ IRGFVYFVET LARSICEKLE QSGLPVGGNE KKAKLANVVR
KMMTNSQDTE LSFTITGDNT KWNENQNPRV FLAMITYITR NQPGWFRNVL SIAPIMFSNK
MARLGKGYMF ESKSMKLRTQ IPAEMLATID LKYFNESTRQ KIEKIRPLLI EGTASLSPGM
MMGMFNMLST VLGVSILNLG QKRYTKTTYW WDGLQSSDDF ALIVNAPNHE GIQAGVDRFY
RTCKLVGINM SKKKSYINRT GTFEFTSFFY RYGFVANFSM ELPSFGVSGI NESADMSIGV
TVIKNNMINN DLGPATAQMA LQLFIKDYRY TYRCHRGDTQ IQTRRSFELK KLWEQTRSKA
GLLVSDGGP
//