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Database: UniProt
Entry: A7YL29_9INFA
LinkDB: A7YL29_9INFA
Original site: A7YL29_9INFA 
ID   A7YL29_9INFA            Unreviewed;       369 AA.
AC   A7YL29;
DT   23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00020035};
DE            EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
DE   Flags: Fragment;
GN   Name=PB1 {ECO:0000313|EMBL:ABL61457.1};
OS   Influenza A virus(A/swine/Henan/4/2004(H9N2)).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus;
OC   Alphainfluenzavirus influenzae; Influenza A virus.
OX   NCBI_TaxID=415168 {ECO:0000313|EMBL:ABL61457.1};
RN   [1] {ECO:0000313|EMBL:ABL61457.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/swine/Henan/4/2004 {ECO:0000313|EMBL:ABL61457.1};
RA   Cong Y., Liu J.;
RT   "Isolation and Characterization of H9N2 Swine Influenza Reassortant Viruses
RT   in China During 2003-2004.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABL61457.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/swine/Henan/4/2004 {ECO:0000313|EMBL:ABL61457.1};
RX   PubMed=18401696; DOI=10.1007/s11262-008-0227-z;
RA   Cong Y.L., Wang C.F., Yan C.M., Peng J.S., Jiang Z.L., Liu J.H.;
RT   "Swine infection with H9N2 influenza viruses in China in 2004.";
RL   Virus Genes 36:461-469(2008).
CC   -!- FUNCTION: RNA-dependent RNA polymerase which is responsible for
CC       replication and transcription of virus RNA segments. The transcription
CC       of viral mRNAs occurs by a unique mechanism called cap-snatching. 5'
CC       methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides
CC       by PA. In turn, these short capped RNAs are used as primers by PB1 for
CC       transcription of viral mRNAs. During virus replication, PB1 initiates
CC       RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn
CC       serves as a template for the production of more vRNAs.
CC       {ECO:0000256|ARBA:ARBA00002148}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC       cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus
CC       {ECO:0000256|ARBA:ARBA00004147}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; DQ981544; ABL61457.1; -; Viral_cRNA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039523; P:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity; IEA:UniProtKB-KW.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   GO; GO:0019083; P:viral transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR   InterPro; IPR001407; RNA_pol_PB1_influenza.
DR   Pfam; PF00602; Flu_PB1; 1.
DR   PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE   4: Predicted;
KW   Eukaryotic host gene expression shutoff by virus
KW   {ECO:0000256|ARBA:ARBA00023247};
KW   Eukaryotic host transcription shutoff by virus
KW   {ECO:0000256|ARBA:ARBA00022731};
KW   Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW   Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW   Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Inhibition of host RNA polymerase II by virus
KW   {ECO:0000256|ARBA:ARBA00023103};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW   Transferase {ECO:0000256|ARBA:ARBA00022484};
KW   Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW   Viral transcription {ECO:0000256|ARBA:ARBA00023314}.
FT   DOMAIN          59..256
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50525"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABL61457.1"
FT   NON_TER         369
FT                   /evidence="ECO:0000313|EMBL:ABL61457.1"
SQ   SEQUENCE   369 AA;  41869 MW;  9348A00DC83470FF CRC64;
     TKDAERGKLK RRAIATPGMQ IRGFVYFVET LARSICEKLE QSGLPVGGNE KKAKLANVVR
     KMMTNSQDTE LSFTITGDNT KWNENQNPRV FLAMITYITR NQPGWFRNVL SIAPIMFSNK
     MARLGKGYMF ESKSMKLRTQ IPAEMLATID LKYFNESTRQ KIEKIRPLLI EGTASLSPGM
     MMGMFNMLST VLGVSILNLG QKRYTKTTYW WDGLQSSDDF ALIVNAPNHE GIQAGVDRFY
     RTCKLVGINM SKKKSYINRT GTFEFTSFFY RYGFVANFSM ELPSFGVSGI NESADMSIGV
     TVIKNNMINN DLGPATAQMA LQLFIKDYRY TYRCHRGDTQ IQTRRSFELK KLWEQTRSKA
     GLLVSDGGP
//
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