ID A7YW30_BOVIN Unreviewed; 210 AA.
AC A7YW30;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE SubName: Full=CD8B protein {ECO:0000313|EMBL:AAI34440.1};
DE SubName: Full=CD8b molecule {ECO:0000313|Ensembl:ENSBTAP00000032971.3};
GN Name=CD8B {ECO:0000313|EMBL:AAI34440.1,
GN ECO:0000313|Ensembl:ENSBTAP00000032971.3};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI34440.1};
RN [1] {ECO:0000313|EMBL:AAI34440.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hereford {ECO:0000313|EMBL:AAI34440.1};
RC TISSUE=Thymus {ECO:0000313|EMBL:AAI34440.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000032971.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000032971.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000032971.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000032971.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; BC134439; AAI34440.1; -; mRNA.
DR RefSeq; NP_001098814.1; NM_001105344.2.
DR STRING; 9913.ENSBTAP00000032971; -.
DR PaxDb; 9913-ENSBTAP00000032971; -.
DR Ensembl; ENSBTAT00000033046.4; ENSBTAP00000032971.3; ENSBTAG00000008956.6.
DR GeneID; 508633; -.
DR KEGG; bta:508633; -.
DR CTD; 926; -.
DR VEuPathDB; HostDB:ENSBTAG00000008956; -.
DR eggNOG; ENOG502SANQ; Eukaryota.
DR GeneTree; ENSGT00510000048998; -.
DR HOGENOM; CLU_089344_0_0_1; -.
DR OMA; RLWLRIH; -.
DR OrthoDB; 5266497at2759; -.
DR TreeFam; TF338028; -.
DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000008956; Expressed in thymus and 91 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR GO; GO:0042288; F:MHC class I protein binding; IEA:InterPro.
DR GO; GO:0050776; P:regulation of immune response; IEA:InterPro.
DR CDD; cd07700; IgV_CD8_beta; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR042414; CD8B.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR11292; T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN; 1.
DR PANTHER; PTHR11292:SF7; T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN-RELATED; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..210
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015086592"
FT TRANSMEM 171..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..117
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 210 AA; 23333 MW; B17BF96AF93E19E4 CRC64;
MQARLWLLLA AQLAALHGSL ALVQTPAFLM VQTNQMVTLS CKTQTSPSNT RIYWLRLRQA
LSANSHYEFL AYWESKKTVY GKEVDSEKLT VHGNPPQSVL TLQNVKPADS GVYFCMIIGI
PNLIFGTGTQ LSVVDVLPTS PQPTKKTSPK KKVCHRVPTQ VTQKRLSCAP LILGLLAAGV
LILLVSLGVA IHLRCLQRRA RLRLLKQFYK
//
