ID   A7ZI58_ECO24            Unreviewed;       310 AA.
AC   A7ZI58;
DT   23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=Transcriptional regulator, LysR family {ECO:0000313|EMBL:ABV18042.1};
GN   OrderedLocusNames=EcE24377A_0334 {ECO:0000313|EMBL:ABV18042.1};
OS   Escherichia coli O139:H28 (strain E24377A / ETEC).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=331111 {ECO:0000313|EMBL:ABV18042.1, ECO:0000313|Proteomes:UP000001122};
RN   [1] {ECO:0000313|Proteomes:UP000001122}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E24377A / ETEC {ECO:0000313|Proteomes:UP000001122};
RX   PubMed=18676672; DOI=10.1128/JB.00619-08;
RA   Rasko D.A., Rosovitz M.J., Myers G.S., Mongodin E.F., Fricke W.F.,
RA   Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA   Henderson I.R., Sperandio V., Ravel J.;
RT   "The pangenome structure of Escherichia coli: comparative genomic analysis
RT   of E. coli commensal and pathogenic isolates.";
RL   J. Bacteriol. 190:6881-6893(2008).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000256|ARBA:ARBA00009437}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000800; ABV18042.1; -; Genomic_DNA.
DR   RefSeq; WP_001089565.1; NC_009801.1.
DR   AlphaFoldDB; A7ZI58; -.
DR   GeneID; 66671383; -.
DR   KEGG; ecw:EcE24377A_0334; -.
DR   HOGENOM; CLU_039613_35_1_6; -.
DR   Proteomes; UP000001122; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 3.40.190.290; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30126; HTH-TYPE TRANSCRIPTIONAL REGULATOR; 1.
DR   PANTHER; PTHR30126:SF18; LYSR FAMILY TRANSCRIPTIONAL REGULATOR-RELATED; 1.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001122};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          10..62
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50931"
SQ   SEQUENCE   310 AA;  34783 MW;  0ED2AFA6C6649769 CRC64;
     MNSVFTEENL LAFTTAARFG SFSKAAEELG LTTSAISYTI KRMETGLDVV LFTRSTRSIE
     LTESGRYFFR KATDLLNDFY AIKRSIDTIS QGIEARVRIC INQLLYTPKH TARLLQVLKK
     QFPTCQITVT TEVYNGVWDA IINNQANIAI GAPDTLLDGG GIDYTEIGAI RWAFAIAPDH
     PLAFVPEPIA ESQLRLYPNI MVEDTAHTIN KKVGWLLHGQ ESILVPDFNT KCQCQILGEG
     IGFLPDYMVR EAMTQSLLVT RQIHNPRQDS RMLLATQHSA TGQVTQWIKK QFAPNGILTG
     IYQDLLHREN
//