ID A7ZSR3_ECO24 Unreviewed; 425 AA.
AC A7ZSR3;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Cell division protein DamX {ECO:0000256|HAMAP-Rule:MF_02021};
GN Name=damX {ECO:0000256|HAMAP-Rule:MF_02021,
GN ECO:0000313|EMBL:ABV17398.1};
GN OrderedLocusNames=EcE24377A_3858 {ECO:0000313|EMBL:ABV17398.1};
OS Escherichia coli O139:H28 (strain E24377A / ETEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=331111 {ECO:0000313|EMBL:ABV17398.1, ECO:0000313|Proteomes:UP000001122};
RN [1] {ECO:0000313|Proteomes:UP000001122}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E24377A / ETEC {ECO:0000313|Proteomes:UP000001122};
RX PubMed=18676672; DOI=10.1128/JB.00619-08;
RA Rasko D.A., Rosovitz M.J., Myers G.S., Mongodin E.F., Fricke W.F.,
RA Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA Henderson I.R., Sperandio V., Ravel J.;
RT "The pangenome structure of Escherichia coli: comparative genomic analysis
RT of E. coli commensal and pathogenic isolates.";
RL J. Bacteriol. 190:6881-6893(2008).
CC -!- FUNCTION: Non-essential cell division protein. {ECO:0000256|HAMAP-
CC Rule:MF_02021}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_02021}; Single-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_02021}. Note=Localizes at the septal ring. {ECO:0000256|HAMAP-
CC Rule:MF_02021}.
CC -!- DOMAIN: The SPOR domain binds septal peptidoglycans and is required to
CC target DamX to the septal ring. {ECO:0000256|HAMAP-Rule:MF_02021}.
CC -!- SIMILARITY: Belongs to the DamX family. {ECO:0000256|HAMAP-
CC Rule:MF_02021}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000800; ABV17398.1; -; Genomic_DNA.
DR RefSeq; WP_000343163.1; NC_009801.1.
DR AlphaFoldDB; A7ZSR3; -.
DR KEGG; ecw:EcE24377A_3858; -.
DR HOGENOM; CLU_048276_1_0_6; -.
DR Proteomes; UP000001122; Chromosome.
DR GO; GO:0030428; C:cell septum; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042834; F:peptidoglycan binding; IEA:InterPro.
DR GO; GO:0032506; P:cytokinetic process; IEA:InterPro.
DR Gene3D; 3.30.70.1070; Sporulation related repeat; 1.
DR HAMAP; MF_02021; DamX; 1.
DR InterPro; IPR032899; DamX.
DR InterPro; IPR007730; SPOR-like_dom.
DR InterPro; IPR036680; SPOR-like_sf.
DR Pfam; PF05036; SPOR; 1.
DR SUPFAM; SSF110997; Sporulation related repeat; 1.
DR PROSITE; PS51724; SPOR; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_02021};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_02021};
KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02021};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_02021};
KW Membrane {ECO:0000256|HAMAP-Rule:MF_02021};
KW Reference proteome {ECO:0000313|Proteomes:UP000001122};
KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_02021};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02021}.
FT TRANSMEM 100..121
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02021"
FT DOMAIN 339..416
FT /note="SPOR"
FT /evidence="ECO:0000259|PROSITE:PS51724"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 425 AA; 45661 MW; D6E43846F6B59715 CRC64;
MDEFKPEDEL KPDPSDRRTG RSRQSSERSE RGEPQINFDD IELDDTDDRR PTRAQKERNE
EPEIEAEIDE SEDETVDEER VERRPRKRKK AASKPASRQY MMMGVGILVL LLLIIGIGSA
LKAPSTSSSD QTASGEKSID LAGNATDQAN GVQPAPGTTS AENTQQDVSL PPISSTPTQG
QTPAATDGQQ RVEVQGDLNN ALTQPQNQQQ LNNVAVNSTL PTEPATVAPV RNGNASRDTA
KTQTAERPST TRPARQQAVI EPKKPQATVK TEPKPVAQTP KRTEPAAPVA STKAPAATST
PAPKETATTA PVQTASPAQT TATPAAGGKT AGNVGSLKSA PSSHYTLQLS SSSNYDNLNG
WAKKENLKNY VVYETTRNGQ PWYVLVSGVY ASKEEAKKAV STLPADVQAK NPWAKPLRQV
QADLK
//
