ID A8AEE7_CITK8 Unreviewed; 433 AA.
AC A8AEE7;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Multidrug resistance protein MdtA {ECO:0000256|HAMAP-Rule:MF_01422};
DE AltName: Full=Multidrug transporter MdtA {ECO:0000256|HAMAP-Rule:MF_01422};
GN Name=mdtA {ECO:0000256|HAMAP-Rule:MF_01422};
GN OrderedLocusNames=CKO_00707 {ECO:0000313|EMBL:ABV11860.1};
OS Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Citrobacter.
OX NCBI_TaxID=290338 {ECO:0000313|EMBL:ABV11860.1, ECO:0000313|Proteomes:UP000008148};
RN [1] {ECO:0000313|EMBL:ABV11860.1, ECO:0000313|Proteomes:UP000008148}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-895 / CDC 4225-83 / SGSC4696
RC {ECO:0000313|Proteomes:UP000008148};
RG The Citrobacter koseri Genome Sequencing Project;
RA McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W.,
RA Johnson M., Thiruvilangam P., Wilson R.;
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC MdtC. {ECO:0000256|HAMAP-Rule:MF_01422}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_01422}; Peripheral membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_01422}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477, ECO:0000256|HAMAP-
CC Rule:MF_01422}.
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DR EMBL; CP000822; ABV11860.1; -; Genomic_DNA.
DR AlphaFoldDB; A8AEE7; -.
DR STRING; 290338.CKO_00707; -.
DR KEGG; cko:CKO_00707; -.
DR HOGENOM; CLU_018816_2_0_6; -.
DR Proteomes; UP000008148; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR HAMAP; MF_01422; MdtA; 1.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR022824; Multidrug-R_MdtA.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR PANTHER; PTHR30469:SF12; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF13437; HlyD_3; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01422};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01422}; Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01422};
KW Reference proteome {ECO:0000313|Proteomes:UP000008148};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|HAMAP-Rule:MF_01422}.
FT TRANSMEM 27..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 105..153
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT REGION 49..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 145..172
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 433 AA; 46665 MW; 946E059355BCEB3E CRC64;
MTKLVSFRET FQDEKLITMK GSKKSRWVIA IVVVVAAIAV YEFWHSRSET QGNAPGANEH
AQRQAGAGRR GMRSGPLAPV QAATATEQAV PRYLTGLGTI AAANTVTVRS RVDGQLMALH
FQEGQQVKAG DLLAEIDPSQ FKVALAQAQG QLAKDKATLA NARRDLARYQ QLVKTNLVSR
QELDAQQALV SETEGTIKAD EASVASAQLQ LDWSRITAPV EGRVGLKQVD VGNQISSGDT
TGIVVITQTH PIDLIFTLPE SDIATVVQAQ KTGKTLTVEA WDRTNSQKLS DGVLLSLDNQ
IDATTGTIKI KARFNNQDDA LFPNQFVNAR MLVDTQQNAV VIPTAAVQMG NEGHFVWVLN
DENKVSKHLV KPGIQDSQNV VISAGLSAGD RVVTDGIDRL TDGAKVEVVE AQAPAAKEDK
ATNREYGKKG VRS
//
