ID   A8AME3_CITK8            Unreviewed;       872 AA.
AC   A8AME3;
DT   23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   RecName: Full=Glycoside hydrolase family 38 central domain-containing protein {ECO:0000259|SMART:SM00872};
GN   OrderedLocusNames=CKO_03577 {ECO:0000313|EMBL:ABV14656.1};
OS   Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter.
OX   NCBI_TaxID=290338 {ECO:0000313|EMBL:ABV14656.1, ECO:0000313|Proteomes:UP000008148};
RN   [1] {ECO:0000313|EMBL:ABV14656.1, ECO:0000313|Proteomes:UP000008148}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-895 / CDC 4225-83 / SGSC4696
RC   {ECO:0000313|Proteomes:UP000008148};
RG   The Citrobacter koseri Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W.,
RA   Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
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DR   EMBL; CP000822; ABV14656.1; -; Genomic_DNA.
DR   RefSeq; WP_012134355.1; NC_009792.1.
DR   AlphaFoldDB; A8AME3; -.
DR   STRING; 290338.CKO_03577; -.
DR   CAZy; GH38; Glycoside Hydrolase Family 38.
DR   GeneID; 45137296; -.
DR   KEGG; cko:CKO_03577; -.
DR   HOGENOM; CLU_003442_2_1_6; -.
DR   OrthoDB; 9764050at2; -.
DR   Proteomes; UP000008148; Chromosome.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10815; GH38N_AMII_EcMngB_like; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF2; MANNOSYLGLYCERATE HYDROLASE; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008148}.
FT   DOMAIN          277..355
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   872 AA;  98511 MW;  29CDB900C6D56A0A CRC64;
     MSNIHVIAHT HWDQEWYFTL QDSNILASWN FADVIRTLEQ NPAYTCYHFD GQTAVVEDFL
     AVNPQYCERL KQLVTDRRLF IGPWYTQTDT YNVHGESIIR NLKYGILSAR KLGHAMMVGY
     LPDTFGHNSQ LPTLLRGCNL DNIVFWRGIN HDTQVEKSQF IWQAPSGAQV IACAMPFGYG
     AAKNIRADDA HLHDKIFPIV NHIRQRSGLN DLLLPCGGDQ VNIDPHLPEI LRIASACSPE
     GDRFQISSLE AYIDRLRQQA SGYDRWQGEL KSPRYTRIHK TIGSVRYDIK KKNYDVEQFL
     LGKLEPTIAL ARYQGIEVNV QWVDQIWKNL LRNHAHDSIG GCNSDATNRD ILHRLEQTEQ
     LSHSLWNLVV KELATASCEE GDLFVINPSA TAWSGIIKAT LYSRTDGIEL SHHARPLPFS
     VLERTQVSGG RTVQVTVQGE KEVELPPYYR WQVAIDAPAL PPLGYTHIQV QESSRTAPAM
     RNCAESAIEN NDYRLALHAG SLSLHDKRNG RVISDLLTFE DCADAGDSYD FSPLEGDVPQ
     RCHTFTLIDC EKGPHIERMT LSATLMLPPS LAARAAQDVQ PYPVRLVCEL RQHDAQLFID
     VSLENTVCDH RLRLLINSDI RTTESIASQP FAVIRRPVAD APADWRQHYR EKPVDIETSE
     GIIAIEENNR SLIINSLGMK EFQICQNGTA QIALTLFKST GVLGRDDLDW RPGRASGINN
     TVVNTPDAQL LKPLHFSLTL ALADRAAPVT LRHLETRVTR QPYTWQNQTL NTLDNRLERF
     TLNFASRSLP ETFSLLTLPE PLMLSAIPHA HTVDGTIIRI FNAGEHPVPL PHSLRNIPQI
     NYLEEPVADC TTILPCSTCD FLFTHQERNE KV
//