ID   A8AUR8_STRGC            Unreviewed;      1582 AA.
AC   A8AUR8;
DT   23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 108.
DE   SubName: Full=LPXTG cell wall surface protein, glycosyl hydrolase family {ECO:0000313|EMBL:ABV09481.1};
GN   OrderedLocusNames=SGO_0208 {ECO:0000313|EMBL:ABV09481.1};
OS   Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 /
OS   DL1 / V288).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=467705 {ECO:0000313|EMBL:ABV09481.1, ECO:0000313|Proteomes:UP000001131};
RN   [1] {ECO:0000313|EMBL:ABV09481.1, ECO:0000313|Proteomes:UP000001131}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288
RC   {ECO:0000313|Proteomes:UP000001131};
RX   PubMed=17720781; DOI=10.1128/JB.01023-07;
RA   Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.;
RT   "Genome-wide transcriptional changes in Streptococcus gordonii in response
RT   to competence signaling peptide.";
RL   J. Bacteriol. 189:7799-7807(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000725; ABV09481.1; -; Genomic_DNA.
DR   STRING; 467705.SGO_0208; -.
DR   KEGG; sgo:SGO_0208; -.
DR   eggNOG; COG3583; Bacteria.
DR   eggNOG; COG4724; Bacteria.
DR   HOGENOM; CLU_003704_0_0_9; -.
DR   Proteomes; UP000001131; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0033925; F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.3630; -; 2.
DR   Gene3D; 1.20.120.1850; Ebh helix bundles repeating unit (S and A modules); 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR032979; ENGase.
DR   InterPro; IPR005201; Glyco_hydro_85.
DR   InterPro; IPR022038; Ig-like_bact.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   NCBIfam; TIGR01168; YSIRK_signal; 1.
DR   PANTHER; PTHR13246:SF1; CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   PANTHER; PTHR13246; ENDO BETA N-ACETYLGLUCOSAMINIDASE; 1.
DR   Pfam; PF07523; Big_3; 2.
DR   Pfam; PF03644; Glyco_hydro_85; 1.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE   4: Predicted;
KW   Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ABV09481.1};
KW   Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001131};
KW   Secreted {ECO:0000256|ARBA:ARBA00022512};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          1550..1582
FT                   /note="Gram-positive cocci surface proteins LPxTG"
FT                   /evidence="ECO:0000259|PROSITE:PS50847"
FT   REGION          55..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1454..1554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1510..1529
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1582 AA;  174401 MW;  9E0CFEFFAF4A9CF9 CRC64;
     MEFYKKQKFS IRKLSLGVCS VLVGIALFGV ADVSAEEKLT ELSQASDVAL VNADAPKEEA
     AEEAQGKPAS EEASQAAQPD TENQAVVEDK KPVVESQDVA IVAEKEEKPA TKEAKVVEDL
     PSQEDKKLKP KEVKFDNWQD LLNWKPGDRE DDDINRASVP LAERYQGHQI NQQANPEAKV
     QALSNMNSKA LDHASTGGEE FKAYAFDYWQ YLHSMVFWDG LVPTSDVIDA AHRNGVPIYG
     TLFFNWSSSA KDQERFAEAL KEDSEGSKTF PIARKLVELA KYYGYDGYFI NQETTGSQVE
     PLGPKMRDFL LYTKEYARSL NYPIKYSWYD AMTYEYGRYH ENALGEYNYQ FMQPKDGENP
     VDTFFANFNW GKAETDYSIS TAKWIKRNPY DVLAGIELQK GGSYKTNVDW EAILDENGKL
     RLSLGLYAPD TITGLGKTGE GYHIHENYFW TGFQGDPSKG KPSDQSWYGM SNLVVDKTAI
     TKPDFNTSFN TGHGKRWFVD GKVSKDGEWN YRSVSGFLPT WRWWIQHSEG SAPLKGRYDF
     DEAYNGGNSL AFEGNLDANS SQNVMLYSTK IPVSDKTKLS LTHKGGQGTS AWVALATKPD
     YSEYEWKELN PSKDWKTETF DLSSLAGKTI YGVKMFFDHD SDVKDYKFNL GQLSIYANQE
     KPAAPKDVVV KAKRLQNAQE AEALLQFKGS ADADYYEIYE KDGDQWRLVT GTSGTSAYLA
     KVTRSASAKG SKQELKVVAV GKNGLRSDAG TVDFDWGMQV SDTSLPKPLA PNVVLGAKVI
     GSSFPDADGS EGIEGMLNGT ITSLSDKWSS AQLSGTVDIR LTQPRTVTRW VMEHAGAGGE
     SVDDGKMNTR DFDLYYKDEA GEWKLAKAVR GNKDHVSDIV LDKPIRAQDW RLDVITADNG
     TPWRAIRIYN WKMYESLDTE TVNVPMKNAA ARVLGNGHVQ VGFKDVAAKT TVSLYESSDA
     KQAIATMTTD KDGNLIFKPL AFAKLPNLLY YRSQVEGKDI SNVLAIEVPK EDKEISKVEL
     ETAPERKVYR QGDALSLKGG TIRVSFKGGE ANQLIQLSNS GVEVTGYDPS KLGEQHLQVS
     YLGQKLDQSL TVYVVSHSEA GEKTPVGLEL IEKPKTDYIV GESLETQGGR FRLVFDDETT
     EEHALDEAGV QVTGYDAHKE GRQTISISYR GVTTTYDVFV SPKPALNDEY LKQKLAEATA
     VQNKVDFSFA SQGNKDALLK EIASAEQILK DHDTSTQGQV DESLSKLTQA FKALDGRKNF
     ATKTSELDTL ATEAQDLLAQ NPNHPSGDAL LNLLNKNKDL LASSEVTPEA LETAKTSLQA
     LIALLKEDKP AVFVDSATGV EVQFSNKETT PVKGLKVGVV EANAAEKEAF AGRLGKVYDI
     EGVDKEGRDI DTQHASLVKI PVEAGKEVEQ VFFFPDNQPV QSLAFEQVGN EVIFTAPHFT
     HYALVYKTAK ASGSDQALKP DQPSEPDKPT VPSNDNSKPL HPQLPGDGHL SPVQPNANPT
     VERLNYQEKD KGSTGYQSQN LANSSSQSVK EEVDSKDVKE ENTVTSAGNL PNTASQETAF
     VAEAVLLAAL GGLLLAGKKK ED
//