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Database: UniProt
Entry: A8AWG9
LinkDB: A8AWG9
Original site: A8AWG9 
ID   UVRC_STRGC              Reviewed;         611 AA.
AC   A8AWG9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   14-MAY-2014, entry version 50.
DE   RecName: Full=UvrABC system protein C;
DE            Short=Protein UvrC;
DE   AltName: Full=Excinuclease ABC subunit C;
GN   Name=uvrC; OrderedLocusNames=SGO_0830;
OS   Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 /
OS   V288).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=29390;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Challis / ATCC 35105 / CH1 / DL1 / V288;
RX   PubMed=17720781; DOI=10.1128/JB.01023-07;
RA   Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.;
RT   "Genome-wide transcriptional changes in Streptococcus gordonii in
RT   response to competence signaling peptide.";
RL   J. Bacteriol. 189:7799-7807(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides
CC       of the lesion. The N-terminal half is responsible for the 3'
CC       incision and the C-terminal half is responsible for the 5'
CC       incision (By similarity).
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the UvrC family.
CC   -!- SIMILARITY: Contains 1 GIY-YIG domain.
CC   -!- SIMILARITY: Contains 1 UVR domain.
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DR   EMBL; CP000725; ABV09388.1; -; Genomic_DNA.
DR   RefSeq; YP_001450129.1; NC_009785.1.
DR   ProteinModelPortal; A8AWG9; -.
DR   SMR; A8AWG9; 2-97, 369-523.
DR   STRING; 467705.SGO_0830; -.
DR   EnsemblBacteria; ABV09388; ABV09388; SGO_0830.
DR   GeneID; 5599348; -.
DR   KEGG; sgo:SGO_0830; -.
DR   PATRIC; 19659617; VBIStrGor124371_0815.
DR   eggNOG; COG0322; -.
DR   HOGENOM; HOG000279960; -.
DR   KO; K03703; -.
DR   OMA; QTIASCV; -.
DR   OrthoDB; EOG6K13R9; -.
DR   BioCyc; SGOR467705:GH3R-829-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   Gene3D; 4.10.860.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR027299; GIY-YIG_dom.
DR   InterPro; IPR000305; GIY-YIG_SF.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_homol_region.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair;
KW   Excision nuclease; SOS response.
FT   CHAIN         1    611       UvrABC system protein C.
FT                                /FTId=PRO_1000077850.
FT   DOMAIN       14     91       GIY-YIG.
FT   DOMAIN      196    231       UVR.
SQ   SEQUENCE   611 AA;  70053 MW;  D94070E5F716AF1E CRC64;
     MNKLIQSKLE LLPTSPGCYI HKDKNGTIIY VGKAKNLRNR VRSYFRGSHD TKTEALVSEI
     VDFEFIVTES NIEALLLEIN LIKENKPKYN IMLKDDKSYP FIKITNETYP RLIITRQVKK
     DGGLYFGPYP DVGAANEIKR LLDRLFPFRK CTNPPEKVCF YYHLGQCKAH TICQVDSQYF
     KDLAQEVAAF LKGQDDQIIE DLRGKMAGAA QTMEFEKAAE YRDLIQSIGT LRTKQRVMAK
     DLQNRDVFGY YVDKGWMCVQ VFFVRQGKLI ERDVNLFPYY NDPDEDFLTY IGQFYQEKSH
     LKPNEILIPA DIDEEAVRAM VDTKVLKPQR GEKKQLVNLA IKNARVSLQQ KFDLLEKSIE
     KTQGAIENLG QLLNIPTPVR IESFDNSNIM GTSPVSAMVV FVNGKPSKKD YRKYKIKTVV
     GPDDYASMRE VIKRRYSRVI RDGLTPPDLI VIDGGQGQVN VAKEVIQEQL GLDIPIAGLQ
     KNDKHQTHEL LFGDPLQVVE LSRNSQEFFL LQRIQDEVHR FAITFHRQLR SKNSFSSQLD
     GIEGLGPKRK QNLMKHFKSL TKIKEASVDE IVEVGVPRAV AEAVQEKLNL KTQEQQQARL
     REVAEPQAEI E
//
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