ID A8B2E5_9HEPC Unreviewed; 166 AA.
AC A8B2E5;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Serine protease {ECO:0000313|EMBL:ABJ52474.1};
DE Flags: Fragment;
GN Name=NS3 {ECO:0000313|EMBL:ABJ52474.1};
OS Hepacivirus hominis.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC Amarillovirales; Flaviviridae; Hepacivirus.
OX NCBI_TaxID=3052230 {ECO:0000313|EMBL:ABJ52474.1};
RN [1] {ECO:0000313|EMBL:ABJ52474.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C {ECO:0000313|EMBL:ABJ52474.1};
RX PubMed=17393500; DOI=10.1002/hep.21623;
RA Franco S., Parera M., Aparicio E., Clotet B., Martinez M.A.;
RT "Genetic and catalytic efficiency structure of an HCV protease
RT quasispecies.";
RL Hepatology 45:899-910(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; EF014042; ABJ52474.1; -; Genomic_RNA.
DR MEROPS; S29.001; -.
DR euHCVdb; EF014042; -.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0019087; P:transformation of host cell by virus; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 2.40.10.120; -; 1.
DR InterPro; IPR004109; NS3_Peptidase_S29.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR Pfam; PF02907; Peptidase_S29; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51822; HV_PV_NS3_PRO; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protease {ECO:0000313|EMBL:ABJ52474.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 1..166
FT /note="Peptidase S29"
FT /evidence="ECO:0000259|PROSITE:PS51822"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABJ52474.1"
FT NON_TER 166
FT /evidence="ECO:0000313|EMBL:ABJ52474.1"
SQ SEQUENCE 166 AA; 17404 MW; CB8D60A4B7D56C25 CRC64;
QTRGLFGCII TSLTGRDKNQ VEGEVQVVST ATQSFLATCV NGVCWTVYHG AGSKTLAGPK
GPVTQMYTNV DQDLVGWQAP PGARSLTPCT CGSSDLYLVT RHADVIPVRR RGDSRGSLLS
PRPVSYLKGS SGGPLLCPLG HAVGIFRAAV CTRGVAKAVD FVPVES
//