ID A8BAA9_GIAIC Unreviewed; 512 AA.
AC A8BAA9;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Notchless {ECO:0000313|EMBL:EDO80675.1};
GN ORFNames=GL50803_0013667 {ECO:0000313|EMBL:KAE8303542.1},
GN GL50803_13667 {ECO:0000313|EMBL:EDO80675.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO80675.1};
RN [1] {ECO:0000313|EMBL:EDO80675.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO80675.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8303542.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8303542.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO80675.1}.
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DR EMBL; AACB02000008; EDO80675.1; -; Genomic_DNA.
DR EMBL; AACB03000002; KAE8303542.1; -; Genomic_DNA.
DR RefSeq; XP_001708349.1; XM_001708297.1.
DR AlphaFoldDB; A8BAA9; -.
DR STRING; 184922.A8BAA9; -.
DR EnsemblProtists; EDO80675; EDO80675; GL50803_13667.
DR GeneID; 5701260; -.
DR KEGG; gla:GL50803_0013667; -.
DR VEuPathDB; GiardiaDB:GL50803_13667; -.
DR HOGENOM; CLU_000288_57_16_1; -.
DR InParanoid; A8BAA9; -.
DR OMA; AWEPYHR; -.
DR Proteomes; UP000001548; Chromosome 4.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19848:SF0; NOTCHLESS PROTEIN HOMOLOG 1; 1.
DR PANTHER; PTHR19848; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2..65
FT /note="NLE"
FT /evidence="ECO:0000259|Pfam:PF08154"
FT REPEAT 98..130
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 140..181
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 225..247
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 395..436
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 437..478
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 479..512
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 512 AA; 56911 MW; A705C2CDCD3A3C87 CRC64;
MIIAQLVTDT GDALAETLEI PEDTTGADLQ EVLRTFRATD PDDVPIKYSF FIGTTEVRGS
LKQAIEAAAV STETTVIITC RPLALFAVKP VSRSVATLEG HTEGVLDVSF NPDGLTFASA
SGDTTIRIWD SLTLTCKHVL RGHKNWVLRV AYSPCATRLA SAGVDGELRI WDPVTNRALH
SRALIGHKRF ISSLAWQPLP LLPVENIPKN SKMSDLISTN TSLRLATGSK DGTVRVWNTD
AGVVEHVVHS GTKCVTDVRW TRDNYLLVSS EDTQTYLYST PYVKHPLVKT DSSSLQAQYC
CLAVLKNHGH WVNSLALNTD YLQRYGPRIC LVMGPAYYKQ MLTQREMVLT CSDDQTINLY
DLAILLDDAR RAILDRADGT DRHFIALSCK PLTRLTGHAK PVNHVCFSPN GQYIASASFD
RTVRLWDGVT GKHISIFRNH VNQCYRVSFS SDSRFLISCG KDSTCKLYSL SKRTMLRDLP
GHEDEVYAID WALDGDIAIS GSKDRTVRVW RN
//
