GenomeNet

Database: UniProt
Entry: A8BGB4_GIAIC
LinkDB: A8BGB4_GIAIC
Original site: A8BGB4_GIAIC 
ID   A8BGB4_GIAIC            Unreviewed;       933 AA.
AC   A8BGB4;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   07-JUN-2017, entry version 43.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=GL50803_18470 {ECO:0000313|EMBL:EDO79484.1};
OS   Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia
OS   lamblia).
OC   Eukaryota; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO79484.1, ECO:0000313|Proteomes:UP000001548};
RN   [1] {ECO:0000313|EMBL:EDO79484.1, ECO:0000313|Proteomes:UP000001548}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548};
RX   PubMed=17901334; DOI=10.1126/science.1143837;
RA   Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA   Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J.,
RA   Davids B.J., Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E.,
RA   Huse S.M., Kim U.U., Lasek-Nesselquist E., Manning G., Nigam A.,
RA   Nixon J.E., Palm D., Passamaneck N.E., Prabhu A., Reich C.I.,
RA   Reiner D.S., Samuelson J., Svard S.G., Sogin M.L.;
RT   "Genomic minimalism in the early diverging intestinal parasite Giardia
RT   lamblia.";
RL   Science 317:1921-1926(2007).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EDO79484.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AACB02000016; EDO79484.1; -; Genomic_DNA.
DR   RefSeq; XP_001707158.1; XM_001707106.1.
DR   STRING; 184922.XP_001707158.1; -.
DR   EnsemblProtists; EDO79484; EDO79484; GL50803_18470.
DR   GeneID; 5700055; -.
DR   KEGG; gla:GL50803_18470; -.
DR   EuPathDB; GiardiaDB:GL50803_18470; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; A8BGB4; -.
DR   KO; K02154; -.
DR   OMA; TIPSFMN; -.
DR   Proteomes; UP000001548; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001548};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    474    496       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    508    532       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    598    620       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    632    654       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    698    718       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    875    897       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   933 AA;  104147 MW;  14658B81D15247B4 CRC64;
     MSALDLWRSQ TMRLVAFTVS REIAPSVVEE MMALGCMHFV DACSDVSFFD RAYTANIMQL
     ATTESKLDYI RDQFIALEIP LPEQEDRVEL MPLGNLDAEL TATMKTVKTL LDEYQQHLAD
     LSANLTYSQV LDIVRRESAS SAQNKMLRDV LSENTHLIGS SPDDEAQETD TSANLYFLAC
     TVPDSVTPML QRLATRATLS NCMIEVVGKI STPDLAALIG ADQSPSKPAS PKKAKHKAAK
     DQQEYDVVFV YTPGVQLQSK VGSIVTSLSG TIHISQGVQG GGAVDSVQSL DSDVSRVQQS
     IEDHRTLLRL SKQRITTILN QLGAQLEAYY RLILKEKEVM GVLNKLRPSL ADAKILTGIA
     WIPEQTFSDV TQIVEACNER YKGMLPSFIK DLNALSKTRK NGTSVLINTD DLRPATVDAL
     HHSPKEHLRQ PPTYFKTGKF TKVFQNIIES YGIPSYKEIN PAFFYLYQFP FTFAVMYGDI
     GHGIILTIVS ALMVGYERRL GKVKNDMVSL IFAGRYIILL MSIFSIFTGL IYNDMFALAY
     DFFHSRYTFN RSSTTPNLFE STYDTTKYSS PVYAFGIDPA WRWSDNSMMF INSYKMKMAV
     IIGILQMIFG IVLKLLNVIY SRDIVGLLTC WIPEFLFMTC FFGYMVFCII YKWLNEWPEG
     SNPPALTSLL IQMFLSPGSI SPESYLFNNI PLQTNLQLAL FAICIISVLW LAVAKPVYEV
     VQLKKAAKKG LAHGVPIFSG QAASHEAAPI TSEADLAKAD TDDAQTDKTN LLVSDGKDAQ
     GRGSSRKADQ DDDDEAHGVG DIVVHQVIHT IEYVLGAISH TASYLRLWAL SLAHAQLSEV
     FYEQLFTLSY GFSVSENKWL SGVVQGVSFF VTYSAWFGVT IGVIILMEAL SAFLHGLRLA
     WIEFNSKFYQ AEGYIFEPLA PVEYTLSLEK QDE
//
DBGET integrated database retrieval system