ID A8BHX6_GIAIC Unreviewed; 1275 AA.
AC A8BHX6;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Ankyrin repeat protein 1 {ECO:0000313|EMBL:KAE8302618.1};
DE SubName: Full=Protein 21.1 {ECO:0000313|EMBL:EDO79266.1};
GN ORFNames=GL50803_005879 {ECO:0000313|EMBL:KAE8302618.1}, GL50803_5879
GN {ECO:0000313|EMBL:EDO79266.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO79266.1};
RN [1] {ECO:0000313|EMBL:EDO79266.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO79266.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8302618.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8302618.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO79266.1}.
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DR EMBL; AACB02000018; EDO79266.1; -; Genomic_DNA.
DR EMBL; AACB03000003; KAE8302618.1; -; Genomic_DNA.
DR RefSeq; XP_001706940.1; XM_001706888.1.
DR AlphaFoldDB; A8BHX6; -.
DR STRING; 184922.A8BHX6; -.
DR EnsemblProtists; EDO79266; EDO79266; GL50803_5879.
DR GeneID; 5699835; -.
DR KEGG; gla:GL50803_005879; -.
DR VEuPathDB; GiardiaDB:GL50803_5879; -.
DR HOGENOM; CLU_006674_0_0_1; -.
DR InParanoid; A8BHX6; -.
DR OMA; NSIACIP; -.
DR Proteomes; UP000001548; Chromosome 3.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR PANTHER; PTHR24120; GH07239P; 1.
DR Pfam; PF12796; Ank_2; 4.
DR SMART; SM00248; ANK; 11.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT REPEAT 35..67
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 989..1021
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1087..1119
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1180..1203
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT COILED 550..598
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 713..740
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1275 AA; 139428 MW; 11080F948A99CF73 CRC64;
MGDSCAFSWF QAAATGNLEV IQALKEQCSG LRNEDGETAL MLAVRNNAMN VVEVLLNSEA
KLTNEDGYTA LLIAAEENNS FACSILLAAE RDICLNDNSD ALILATEAGA MDAICILAPG
WPVRRTTEGI AAIDIASNES NLKAVNLLLQ GQDLTCEDVE RAMLHANEDD DNYDSICSAL
QGYLVSLGAR SSTPGRDVPL ELSDYDAVPD AIQYCPSLPQ DSLPLAYSAL DNTDVAMTKI
SLEESDDISK AILMPGAVTP ISQQLNADLQ EVTPTEQRCK PIIDELEGEA SSDEIQPDPT
EFYEEKRLSE GLASSTVFQL TNMIQEHNPM SELVKIIDCK DAEIQELRLL IDTLQNRKPI
SDDARFYSTG QSASQEAPNF PEEPPIVISA TTSIALSTID TLRSRIAELE GKLAEHPPTH
ELVDTETQYS VNTIVFSATA DQADKCLGCN VETTTPKEIE QILLENSHLS AKLQQAENEV
MALGRCLTDA IAASDNVEAN LILQDFAHRE RILIDSYVSR IENLQTSMDM FIGIQKRKAK
ESEAYFHAQL EEITEQNTLA NKAIRNLTLQ IETSNSELQE LRGTIAYLNE ENASLSDALK
LAKAVQEQVS NEIAGSAINI TTTSVTVQTE PTCDSVPGPD LSPDNVTTMH DLPKCTTQKE
LDEAMLNAIL NQALCTTDYS GLLSDTVLFA IAPDLEITVS NVFQAVTWFY NESEQKERRL
SEAEEKLEVM ANLCENLSAE LKEKYSLILD ISPDGTGEYT ISCAEPLGNP RGHQGEISDH
PDSLVLQPII PIEQSNSSDV SLKPLQSHSD VHSLLQVEDL ELPSLPKAGS PSKSIEISFD
KDLSASPPVH LQVPLISINK PEKKTTSKPK PVNNIPMLVE DETSSLMLPS IHAGEFRATK
LKQIGNDISP TTTHADRTDM QRAHDLQERA LQLSHDAVSP YLTHKEEPAP ILEQNSNQGD
DTPLIAAVLK GQNSEIRRYL QYAGRFNGDG VTALMIAAMR NNLEAAQLLV EYEKGLTTAD
GSTALCLALL KGNMPVAKFL TPYEGLDFSH VSSKGRRFTE LMQAADEDNI VAVWCLIPHQ
GGLRDEEGFT ALMYAVQAGH YEVARILYEL EGRVRNVNGE TALMLAAASG FTRIANMLVI
KEAGERDNQG RTALMRAAIY NHCDVIRLLL QKEGGIQDSR GETALMFAAK ANNPEAVRLL
LDKEGGKRML VKQPGRNGTQ LRGPGYTALI QAVRKNSIAC IPLLLSREAG FKDAEGRAPI
LFAKTKETRD LLLRE
//
