ID A8BNI1_GIAIC Unreviewed; 1172 AA.
AC A8BNI1;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 28-JUN-2023, entry version 67.
DE SubName: Full=Metalloendopeptidase {ECO:0000313|EMBL:KAE8302521.1};
DE SubName: Full=Metalloprotease, insulinase family {ECO:0000313|EMBL:EDO78244.1};
GN ORFNames=GL50803_009508 {ECO:0000313|EMBL:KAE8302521.1}, GL50803_9508
GN {ECO:0000313|EMBL:EDO78244.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO78244.1};
RN [1] {ECO:0000313|EMBL:EDO78244.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO78244.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8302521.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8302521.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO78244.1}.
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DR EMBL; AACB02000028; EDO78244.1; -; Genomic_DNA.
DR EMBL; AACB03000004; KAE8302521.1; -; Genomic_DNA.
DR RefSeq; XP_001705918.1; XM_001705866.1.
DR AlphaFoldDB; A8BNI1; -.
DR STRING; 184922.A8BNI1; -.
DR EnsemblProtists; EDO78244; EDO78244; GL50803_9508.
DR GeneID; 5698803; -.
DR KEGG; gla:GL50803_009508; -.
DR VEuPathDB; GiardiaDB:GL50803_9508; -.
DR HOGENOM; CLU_274009_0_0_1; -.
DR InParanoid; A8BNI1; -.
DR OMA; NHIELEY; -.
DR Proteomes; UP000001548; Chromosome 2.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR GO; GO:0016485; P:protein processing; IBA:GO_Central.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR013578; Peptidase_M16C_assoc.
DR PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR Pfam; PF08367; M16C_assoc; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SMART; SM01264; M16C_associated; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:EDO78244.1};
KW Metalloprotease {ECO:0000313|EMBL:EDO78244.1};
KW Protease {ECO:0000313|EMBL:EDO78244.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT DOMAIN 515..796
FT /note="Peptidase M16C associated"
FT /evidence="ECO:0000259|SMART:SM01264"
SQ SEQUENCE 1172 AA; 131439 MW; 1E09FB9E037C47A7 CRC64;
MLVDRAHSLP LGTTIRGFTV VESEYVSETS TQLIKLIHEQ SGLTVFKHIP QDASYTENSA
NIAFATFASD DKGLPHITEH SVFCGSELYP HKDPFNEVTK TSLKVYNNAF TAQTHTVYEF
ASRCKRDYFN ILSVYLDAVF RPALLKDPRI YAQEGWHLHL ETEDGEIVQS GIVLNEMKSR
CASPSTVLVY NLQRLLYGGT AMGYETGGLP DAVVTGTHTD IAEFYKRFYY PGNCVIAFHG
NIPLEDELRA IVEPYLLDYV GGEGPALSKR SPPTPILYRD QPNLPELTKD EVSAQARVSS
RSARRVRFVE YGVSKETKAL KKEGIIGRIY YLFDLRDATP LLLLSVRVLD YILFDQTSSP
VPESLQSSSL CKSCYSMLDC TELQCTLYLS FLGCEHTEEG YLALISAYED LLTELMSPER
DGQYYRFLSP QAVDAALNHI ELEYRDIRPY SGLGVNNRTI SAALAGCPST TRLLYEEPLR
ELRKLVIDGT VTEYLCGVLA KYLTALNPHQ ADVVLVPIPG YLEQCEEATQ QRLRALKASM
SPEDIQALIS NTKSQIRRAL EPTPQEINEL LPMLRIEEID AVNTDMFKAQ SFLHYDLRVS
PHLMPVLYCH TGEQGKNLTY LEVCTDITDM CDLETLPLLS LLANHILGEV ATTSYKTVES
LHRAIDYYTG DFSISLKAED IPPFLRDVKH PTSQTCTSIP SRIYMSISAT CKDTDTEAVL
RLIFHEILGG SIVGLTNPRV LLRLLHEFWM SLREDIVEGD GHLVASRRAS AVCGRLTSFV
YELASGPSMY NWLSKFLRDT LADHSSGTGS LEDGSGAAEE EICHSDNSFE GDDNEDEDDA
FLDNDSTKQE LCLLGEQLAA LLAKMCARPE LFLVCVGQRI SDLAPYVAKT RYAPEDMRKI
QSILAQHTFN AELLRVVDNS YSLRPGKLSL WVKRRNTCPL AEQFNRLLTW YRCEDQSLPL
DADLADYSGV FNSLAIPSDV SYVARAYLPS LAENLAIGRS HLSGNIPAKY LSLHIIENVY
LWDNVRIKNG AYGCLLKLRL NGSAILFSYD DSRVVETIKI YDKLSESAEE LYGSLDKRTL
DGYKIGCLSA NQIGISPKEI FKQAIYYFMA GYSVRRHYRE IKQTLRVTKD ALMKAHEYFS
NLSSAPSVIV GSASSCRDAF AKGLIRKYDV FE
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