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Database: UniProt
Entry: A8BXH5_9INFA
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Original site: A8BXH5_9INFA 
ID   A8BXH5_9INFA            Unreviewed;       483 AA.
AC   A8BXH5;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00020035};
DE            EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
DE   Flags: Fragment;
GN   Name=PB1 {ECO:0000313|EMBL:ABV48100.1};
OS   Influenza A virus (A/chukkar/Shantou/1447/2004(H9N2)).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus;
OC   Alphainfluenzavirus influenzae; Influenza A virus.
OX   NCBI_TaxID=456660 {ECO:0000313|EMBL:ABV48100.1};
RN   [1] {ECO:0000313|EMBL:ABV48100.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/chukkar/Shantou/1447/2004 {ECO:0000313|EMBL:ABV48100.1};
RX   PubMed=17652402; DOI=10.1128/JVI.00979-07;
RA   Xu K.M., Smith G.J., Bahl J., Duan L., Tai H., Vijaykrishna D., Wang J.,
RA   Zhang J.X., Li K.S., Fan X.H., Webster R.G., Chen H., Peiris J.S., Guan Y.;
RT   "The genesis and evolution of H9N2 influenza viruses in poultry from
RT   southern China, 2000 to 2005.";
RL   J. Virol. 81:10389-10401(2007).
RN   [2] {ECO:0000313|EMBL:ABV48100.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/chukkar/Shantou/1447/2004 {ECO:0000313|EMBL:ABV48100.1};
RA   Xu K., Smith G., Bahl J., Duan L., Tai H., Vijaykrishna D., Wang J.,
RA   Zhang J., Li K., Fan X., Webster R., Chen H., Peiris J., Guan Y.;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-dependent RNA polymerase which is responsible for
CC       replication and transcription of virus RNA segments. The transcription
CC       of viral mRNAs occurs by a unique mechanism called cap-snatching. 5'
CC       methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides
CC       by PA. In turn, these short capped RNAs are used as primers by PB1 for
CC       transcription of viral mRNAs. During virus replication, PB1 initiates
CC       RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn
CC       serves as a template for the production of more vRNAs.
CC       {ECO:0000256|ARBA:ARBA00002148}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC       cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus
CC       {ECO:0000256|ARBA:ARBA00004147}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; CY024286; ABV48100.1; -; Viral_cRNA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039523; P:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity; IEA:UniProtKB-KW.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   GO; GO:0019083; P:viral transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR   InterPro; IPR001407; RNA_pol_PB1_influenza.
DR   Pfam; PF00602; Flu_PB1; 1.
DR   PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE   4: Predicted;
KW   Eukaryotic host gene expression shutoff by virus
KW   {ECO:0000256|ARBA:ARBA00023247};
KW   Eukaryotic host transcription shutoff by virus
KW   {ECO:0000256|ARBA:ARBA00022731};
KW   Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW   Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW   Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Inhibition of host RNA polymerase II by virus
KW   {ECO:0000256|ARBA:ARBA00023103}; Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW   Transferase {ECO:0000256|ARBA:ARBA00022484};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW   Viral transcription {ECO:0000256|ARBA:ARBA00023314}.
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          286..483
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50525"
FT   REGION          50..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         483
FT                   /evidence="ECO:0000313|EMBL:ABV48100.1"
SQ   SEQUENCE   483 AA;  54842 MW;  E100EDEB63926664 CRC64;
     MDVNPTLLFL KVPAQNAIST TFPYTGDPPY SHGTGTGYTM DTVNRTHQYS EKGKWTTNTE
     TGASQLNPID GPLPEDNEPS GYAQTDCVLE AMAFLEESHP GLFENSCLET MEVVQQTRVD
     KLTQGRQTYD WTLNRNQPAA TALANTIEVF RSNSLTASES GRLIDFLKDV MESMDKEEME
     ITTHFQRKRR VRDNMTKKMV TQRTIGKKKQ RLTKKSYLIR ALTLNTMTKD AERGKLKRRA
     IATPGMQIRG FVHFVEALAR SICEKLEQSG LPVGGNEKKA KLANVVRKMM TNSQDTELSF
     TVTGDNTKWN ENQNPRIFLA MITYITRKQP EWFRNVLSIA PIMFSNKMAR LGKGYMFESK
     SMKLRTQIPA EMLAHIDLKY FNESTRKKIE KIRPLLIEGT ASLSPGMMMG MFNMLSTVLG
     VSILNLGQKR YTKTTYWWDG LQSSDDFSLI VNAPNHEGIQ AGVDRFYRTC KLVGINMSKK
     KSY
//
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