ID A8CVK3_9MYCO Unreviewed; 232 AA.
AC A8CVK3;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Anti-sigma-K factor RskA {ECO:0000256|RuleBase:RU363049};
DE AltName: Full=Sigma-K anti-sigma factor RskA {ECO:0000256|RuleBase:RU363049};
GN Name=rskA {ECO:0000256|RuleBase:RU363049,
GN ECO:0000313|EMBL:ABV48754.1};
GN ORFNames=IAR57_02260 {ECO:0000313|EMBL:MBC9074384.1};
OS Mycobacterium canettii.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=78331 {ECO:0000313|EMBL:ABV48754.1};
RN [1] {ECO:0000313|EMBL:ABV48754.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18203833; DOI=10.1128/JB.01452-07;
RA Veyrier F., Said-Salim B., Behr M.A.;
RT "Evolution of the mycobacterial SigK regulon.";
RL J. Bacteriol. 190:1891-1899(2008).
RN [2] {ECO:0000313|EMBL:MBC9074384.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NLA000701671 {ECO:0000313|EMBL:MBC9074384.1};
RA Silva-Pereira T., Banari A.C., Guimaraes A.M.S.;
RT "Assembly de novo of Mycobacterium canettii NLA000201913.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: An anti-sigma factor for extracytoplasmic function (ECF)
CC sigma factor SigK. ECF sigma factors are held in an inactive form by an
CC anti-sigma factor until released by regulated intramembrane proteolysis
CC (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted
CC proteolytic cascade to transmit information and elicit cellular
CC responses. The membrane-spanning regulatory substrate protein is first
CC cut extracytoplasmically (site-1 protease, S1P), then within the
CC membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic
CC proteases finish degrading the regulatory protein, liberating the sigma
CC factor. {ECO:0000256|RuleBase:RU363049}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162,
CC ECO:0000256|RuleBase:RU363049}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004162, ECO:0000256|RuleBase:RU363049}.
CC Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- DOMAIN: The cytosolic domain interacts with sigma factor SigK.
CC {ECO:0000256|RuleBase:RU363049}.
CC -!- SIMILARITY: Belongs to the anti-sigma-K factor family.
CC {ECO:0000256|RuleBase:RU363049}.
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DR EMBL; EU122437; ABV48754.1; -; Genomic_DNA.
DR EMBL; JACTAP010000011; MBC9074384.1; -; Genomic_DNA.
DR RefSeq; WP_014000235.1; NZ_OU917987.1.
DR AlphaFoldDB; A8CVK3; -.
DR GeneID; 45424405; -.
DR OMA; VYQMWLI; -.
DR Proteomes; UP000617939; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.10.1320; Anti-sigma factor, zinc-finger domain; 1.
DR InterPro; IPR018764; Anti-sigma_K_RskA.
DR InterPro; IPR041916; Anti_sigma_zinc_sf.
DR PANTHER; PTHR37461; ANTI-SIGMA-K FACTOR RSKA; 1.
DR PANTHER; PTHR37461:SF1; ANTI-SIGMA-K FACTOR RSKA; 1.
DR Pfam; PF10099; RskA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU363049}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU363049};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU363049};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 232 AA; 23868 MW; B14E928C7EC017EB CRC64;
MTEHTDFELL ELATPYALNA VSDDERADID RRVAAAPSPV AAAFNDEVRA VRETMAVVSA
ATTAEPPAHL RTAILDATIP EVRRQSRWRT AAFASAAAIA VGLGAFGLGV LTRPSPPPTV
AEQVLTAPDV RTVSRPLGAG TATVVFSRDR NTGLLVMNNV APPSRGTVYQ MWLLGGAKGP
RSAGTMGTAA VTPSTTATLT DLGASTALAF TVEPGTGSPQ PTGTILAELP LG
//
