ID A8DY25_MUSDO Unreviewed; 507 AA.
AC A8DY25;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Cytochrome P450 CYP6A5v2 {ECO:0000313|EMBL:ABV48810.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:ABV48810.1};
RN [1] {ECO:0000313|EMBL:ABV48810.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhu F., Zhang L., Liu N.;
RT "Permethrin Induction and Overexpression of Three Novel Cytochrome P450
RT Genes in Insecticide Resistant House Flies, Musca domestica.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Microsome membrane
CC {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004174}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EF615004; ABV48810.1; -; mRNA.
DR AlphaFoldDB; A8DY25; -.
DR SMR; A8DY25; -.
DR VEuPathDB; VectorBase:MDOA005584; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd11056; CYP6-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24292:SF100; CYP6A16, ISOFORM B-RELATED; 1.
DR PANTHER; PTHR24292; CYTOCHROME P450; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 2: Evidence at transcript level;
KW Heme {ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033,
KW ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000461}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 507 AA; 58689 MW; 743188F67A0EEFCF CRC64;
MLSLVQTILL AFVAVLIGYL YNLYTYWKRR GVVYERPWPL FGNFWGIGTK YHIREINQRL
YRKFKGQAPF VGTYMFVRRA SLIIDLDLIK NILIKDFANF HDRGVFNNVE DDPLTGHLVA
LEGEQWRAMR TKLSPVFTSA RMKYMFSTVV RVGENLHRVM GDMLSEKSDQ ILEIKDVCAR
FTTDVIGTCA FGIECNSLRD PDAEFRQKGK DIFGKPRHSP LVQIFTITNS NLAKKLHMKL
FPDDVADFFM SVIRQTVEYR EKNNVKCNDF MDLLIEMKAK NEEEAKAGKG IDLSLGLTLE
QMAAQTFVFF LAGFETSSTT MSFALYELAK HPEVQEQLRK EIRESLEKTK GELTYESLHE
MQYLEQVIAE TLRIYPVLPN LIRLTKSDYQ VPNTNHVLEK GIMTVIPVHA IHHDPEYYEN
PDEFRPSRFT PEECLKRHPS AYLPFGDGPR NCIGMRFGKM QTKIGLVSLL RHYRFECSPL
TEIPLEMDKR NFLAATKNGI FLKVIPL
//
