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Database: UniProt
Entry: A8GHC0_SERP5
LinkDB: A8GHC0_SERP5
Original site: A8GHC0_SERP5 
ID   A8GHC0_SERP5            Unreviewed;       553 AA.
AC   A8GHC0;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   31-JAN-2018, entry version 67.
DE   SubName: Full=Thiamine pyrophosphate protein TPP binding domain protein {ECO:0000313|EMBL:ABV42510.1};
GN   OrderedLocusNames=Spro_3412 {ECO:0000313|EMBL:ABV42510.1};
OS   Serratia proteamaculans (strain 568).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=399741 {ECO:0000313|EMBL:ABV42510.1, ECO:0000313|Proteomes:UP000007074};
RN   [1] {ECO:0000313|EMBL:ABV42510.1, ECO:0000313|Proteomes:UP000007074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=568 {ECO:0000313|EMBL:ABV42510.1,
RC   ECO:0000313|Proteomes:UP000007074};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Kim E., Taghavi S., Newman L., Vangronsveld J., van der Lelie D.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Serratia proteamaculans 568.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; CP000826; ABV42510.1; -; Genomic_DNA.
DR   RefSeq; WP_012146125.1; NC_009832.1.
DR   ProteinModelPortal; A8GHC0; -.
DR   STRING; 399741.Spro_3412; -.
DR   EnsemblBacteria; ABV42510; ABV42510; Spro_3412.
DR   KEGG; spe:Spro_3412; -.
DR   eggNOG; ENOG4107RA9; Bacteria.
DR   eggNOG; COG3961; LUCA.
DR   HOGENOM; HOG000061334; -.
DR   KO; K04103; -.
DR   OMA; EWIGNCN; -.
DR   OrthoDB; POG091H0FS6; -.
DR   BioCyc; SPRO399741:GI55-3475-MONOMER; -.
DR   Proteomes; UP000007074; Chromosome.
DR   GO; GO:0016831; F:carboxy-lyase activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   Gene3D; 3.40.50.1220; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR012110; TPP_enzyme.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   PIRSF; PIRSF036565; Pyruvt_ip_decrb; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007074};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR036565-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR036565-2};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN        6    177       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      199    324       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      394    528       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
FT   METAL       435    435       Magnesium. {ECO:0000256|PIRSR:
FT                                PIRSR036565-2}.
FT   METAL       462    462       Magnesium. {ECO:0000256|PIRSR:
FT                                PIRSR036565-2}.
FT   METAL       464    464       Magnesium; via carbonyl oxygen.
FT                                {ECO:0000256|PIRSR:PIRSR036565-2}.
SQ   SEQUENCE   553 AA;  60180 MW;  DCF5B502CD5836B2 CRC64;
     MNTTYRVADY LLDRLAQIGI RHFFGVPGDY NLQFLDHVIS HPQITWVGCA NELNAAYAAD
     GYARCKPAAA LLTTFGVGEL SALNGIAGSY AEYLPVIHVV GAPTLRAQRA GDLLHHSLGD
     GDFGHFARMA KEVTVAQASL TPDNAEAEID RLLTIALFEH RPVYIVLPSE VAEAPLASRP
     APLVLRQAHL SQASLQAFIA AARQMLLPAR RVSLLADFLA ERFGAEKVLE QWMNEVEIPH
     STMLLGKSVL DETHACFTGT YAGAASDPQV KQLIEGADVV INVGVRFTDT ITAGFSHHLP
     AEKCIDLQPF EARVGQQVFS QIPLRDAVIA LHQLTLSLAK QWPVPAIKRP TLPDPNGSGL
     DQHGFWQQIQ DFLRPGDILI AEQGTACFGA AALGLPQGCR FIVQSLWGSI GYTLPAAFGA
     QTAEPDRRVV LLIGDGSAQL TAQELGSMLR DGQKPVIFLL NNEGYTVERA IHGPQQRYND
     IAQWNWTQLP QALAGEHQVK TLRVADPQQL RQALKEVGDS PQLAFVEVML PKMDIPELLD
     SVSRAIHSRN AAA
//
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