ID A8HY72_CHLRE Unreviewed; 1209 AA.
AC A8HY72;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Retinoblastoma-like protein {ECO:0000313|EMBL:BAN18553.1};
GN Name=mat3 {ECO:0000313|EMBL:BAN18553.1};
GN ORFNames=CHLRE_06g255450v5 {ECO:0000313|EMBL:PNW81668.1};
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055 {ECO:0000313|EMBL:PNW81668.1, ECO:0000313|Proteomes:UP000006906};
RN [1] {ECO:0000313|EMBL:PNW81668.1, ECO:0000313|Proteomes:UP000006906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503 {ECO:0000313|Proteomes:UP000006906}, and CC-503 cw92 mt+
RC {ECO:0000313|EMBL:PNW81668.1};
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
RN [2] {ECO:0000313|EMBL:BAN18553.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=8511B {ECO:0000313|EMBL:BAN18553.1};
RX PubMed=23364323; DOI=10.1093/molbev/mst018;
RA Hiraide R., Kawai-Toyooka H., Hamaji T., Matsuzaki R., Kawafune K., Abe J.,
RA Sekimoto H., Umen J., Nozaki H.;
RT "The Evolution of Male-Female Sexual Dimorphism Predates the Gender-Based
RT Divergence of the Mating Locus Gene MAT3/RB.";
RL Mol. Biol. Evol. 30:1038-1040(2013).
RN [3] {ECO:0000313|EMBL:PNW81668.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CC-503 cw92 mt+ {ECO:0000313|EMBL:PNW81668.1};
RG Chlamydomonas Annotation Team;
RG JGI Annotation Team;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Grigoriev I.V., Rokhsar D.S.;
RT "WGS assembly of Chlamydomonas reinhardtii.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR EMBL; AB771948; BAN18553.1; -; mRNA.
DR EMBL; CM008967; PNW81668.1; -; Genomic_DNA.
DR RefSeq; XP_001696629.1; XM_001696577.1.
DR STRING; 3055.A8HY72; -.
DR PaxDb; 3055-EDP08606; -.
DR EnsemblPlants; PNW81668; PNW81668; CHLRE_06g255450v5.
DR Gramene; PNW81668; PNW81668; CHLRE_06g255450v5.
DR eggNOG; KOG1010; Eukaryota.
DR HOGENOM; CLU_269949_0_0_1; -.
DR OMA; FYNRHID; -.
DR OrthoDB; 519973at2759; -.
DR Proteomes; UP000006906; Chromosome 6.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20601; CYCLIN_AtRBR_like; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742:SF17; RETINOBLASTOMA-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 2: Evidence at transcript level;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006906};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 76..217
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 423..626
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT REGION 655..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1031..1209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..757
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1011
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1093
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1145
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1185..1199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1209 AA; 127034 MW; 188C8733B58BB3FC CRC64;
MSTTHPPERG LVALIKGLTI GNVPALQPDV LELYAELKGA YEAQERAAPR EYAGDQDEDV
KQACKQASLL FVARVLSAAQ KKEKDGSETQ PSNLGLSISR IVAVAGINLL DFFREVHVVV
SELSAYFESR GSSSKQFSQQ ALLKENSETV VVMGLLAKKY KDNFNTFLHQ LDFYKQVVLR
LGWSAFLVLR VKLLSAFPDV VSCVELLPCI FAILASHAPR LPDCLTHITR ENRGKFLLKS
MADTCKADYG RVQARMPSVE ALLTQVFTSA VPEWRTAVAE AKAKALSDAS GPAAVGGVDL
VASPVLEGLV TDTDRMNRVV AALEREYEQH YSRGATELDE REFLSTDFTK FASPRFSPGH
MHSTMAKLRS GSMPLRSGGP LGPGLHTATP AHPGPQQLHL VPLGLHSPLP MMHLNAGPGV
PGTPISEAMG ASAWLRGVTS NMVAEPSPTL QRFLAALPIN SNSSGPTPVQ QLMKRVRDLV
ASVIPDEAAP SLLGPFPLLN TSLGAERRIE ATKLYCHSLD TILQNEQRTN GLPAALALLG
SAKFQRGLIA CCIEVVAACY RMVSCAFPNV LDALRIKAFD MANIIGTFVK SIATLPRELK
RHLFLIEEKI LECLAWEPGS SLYHLIVNVH TENEAAAAAA AAAMQEAAAT AACSAASGDD
SQHDGAGSRA GLSSSSGGAG AAAAAEGGAD GGTEQPGASS SHNTEQSGGA PPMETAEGGA
PGAATSAPPS TTPAAPAEPA PPAAASPAAP AASHAPPPSP KRSQGVAFSG MMSPAKKARG
TDGGAHSTQS YIESLPNAVG FPPAAGAAQG QAGLLFEFLR KVLKLTSFRL ALLCENFDFS
PLEGPEVNSK VYEAIEHALY KQTHLFYNRH IDQIMLSTLY GYCKVHKLSQ VSFREIIAQY
RKQPQAQQSI FRSVVIDQVL PTLQIQSRAD IIGFYNAVFV PAMRNFLLKS ESNGSGASGP
GLGGDSKHAA AGNSGNAVGA AAGAAPAQGV GATSAMPPGL PPLPPRASQS PRGPKLPLLG
AIAAAPRMLG RSASGNARGG GERELGMPLL HPLLPTGSST GGGALSPTKG SEGSGHPTPT
GPVPVSRSSN GGRGGSGGRG GGRGSAEHKI PEGLAALLQA LDSQKAAEEN GAEEEEEEEE
VDADEEQPQA RVTRSGRTAR DRSTGRERRG RHTEARDDMD EASMDAEFSQ QTVVTGRRQR
TPNRRYGAD
//
