ID A8IMB9_MACNE Unreviewed; 300 AA.
AC A8IMB9;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=TRIM5alpha {ECO:0000256|ARBA:ARBA00032496};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|EMBL:ABV82953.1};
RN [1] {ECO:0000313|EMBL:ABV82953.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A01150 {ECO:0000313|EMBL:ABV82953.1};
RX PubMed=17804491; DOI=10.1128/JVI.02499-06;
RA Brennan G., Kozyrev Y., Kodama T., Hu S.L.;
RT "Novel TRIM5 isoforms expressed by Macaca nemestrina.";
RL J. Virol. 81:12210-12217(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family.
CC {ECO:0000256|ARBA:ARBA00008518}.
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DR EMBL; EU169826; ABV82953.1; -; mRNA.
DR AlphaFoldDB; A8IMB9; -.
DR UniPathway; UPA00143; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd19761; Bbox2_TRIM5-like; 1.
DR CDD; cd16591; RING-HC_TRIM5-like_C-IV; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF416; TRIPARTITE MOTIF-CONTAINING PROTEIN 5; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 15..60
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 92..133
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT COILED 137..171
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 195..222
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 300 AA; 34913 MW; 0A7885FEE6031C58 CRC64;
MASGILVNVK EEVTCPICLE LLTEPLSLHC GHSFCQACIT ANHEKSMLYK EGERSCPVCR
ISYQPENIQP NRHVANIVEK LREVKLSPEE GQKVDHCARH GEKLLLFCQE DSKVICWLCE
RSQEHRGHHT FLMEEVAQEY HVKLQTALEM LRQKQQEAGK LEADIREEKA SWKIQIDHDK
TNVLADFEQL REILDREESN ELQNLEKEKE DILKSLTKSE TKMVQQTQYV RELISDLEHR
LQGSMMELLQ GVDGIIKRIE NMTLKKPKTF HKNQRRVFRA PDLKGMLDMF RANRCPTLLG
//
