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Database: UniProt
Entry: A8J1K0_CHLRE
LinkDB: A8J1K0_CHLRE
Original site: A8J1K0_CHLRE 
ID   A8J1K0_CHLRE            Unreviewed;       862 AA.
AC   A8J1K0;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   07-JUN-2017, entry version 48.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATPvA2 {ECO:0000313|EMBL:EDP01931.1};
GN   ORFNames=CHLREDRAFT_438 {ECO:0000313|EMBL:EDP01931.1};
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; Chlorophyceae;
OC   Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055 {ECO:0000313|Proteomes:UP000006906};
RN   [1] {ECO:0000313|EMBL:EDP01931.1, ECO:0000313|Proteomes:UP000006906}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC-503 {ECO:0000313|Proteomes:UP000006906};
RX   PubMed=17932292; DOI=10.1126/science.1143609;
RA   Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA   Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K.,
RA   Marechal-Drouard L., Marshall W.F., Qu L.H., Nelson D.R.,
RA   Sanderfoot A.A., Spalding M.H., Kapitonov V.V., Ren Q., Ferris P.,
RA   Lindquist E., Shapiro H., Lucas S.M., Grimwood J., Schmutz J.,
RA   Cardol P., Cerutti H., Chanfreau G., Chen C.L., Cognat V., Croft M.T.,
RA   Dent R., Dutcher S., Fernandez E., Fukuzawa H., Gonzalez-Ballester D.,
RA   Gonzalez-Halphen D., Hallmann A., Hanikenne M., Hippler M., Inwood W.,
RA   Jabbari K., Kalanon M., Kuras R., Lefebvre P.A., Lemaire S.D.,
RA   Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L., Mittag M.,
RA   Mittelmeier T., Moroney J.V., Moseley J., Napoli C., Nedelcu A.M.,
RA   Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J., Purton S.,
RA   Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L., Schroda M.,
RA   Stern D., Umen J., Willows R., Wilson N., Zimmer S.L., Allmer J.,
RA   Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA   Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA   Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA   Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P.,
RA   Jorgensen R., Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T.,
RA   Brokstein P., Dubchak I., Goodstein D., Hornick L., Huang Y.W.,
RA   Jhaveri J., Luo Y., Martinez D., Ngau W.C., Otillar B., Poliakov A.,
RA   Porter A., Szajkowski L., Werner G., Zhou K., Grigoriev I.V.,
RA   Rokhsar D.S., Grossman A.R.;
RT   "The Chlamydomonas genome reveals the evolution of key animal and
RT   plant functions.";
RL   Science 318:245-250(2007).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; DS496132; EDP01931.1; -; Genomic_DNA.
DR   RefSeq; XP_001695223.1; XM_001695171.1.
DR   UniGene; Cre.19278; -.
DR   STRING; 3055.EDP01931; -.
DR   PaxDb; A8J1K0; -.
DR   ProMEX; A8J1K0; -.
DR   EnsemblPlants; EDP01931; EDP01931; CHLREDRAFT_438.
DR   GeneID; 5720728; -.
DR   Gramene; EDP01931; EDP01931; CHLREDRAFT_438.
DR   KEGG; cre:CHLREDRAFT_438; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; A8J1K0; -.
DR   KO; K02154; -.
DR   OMA; TIPSFMN; -.
DR   Proteomes; UP000006906; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000325; C:plant-type vacuole; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006906};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006906};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    412    436       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    456    474       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    561    580       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    592    612       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    649    668       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    795    816       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       93    127       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   862 AA;  96910 MW;  D46F7F11ED7544C2 CRC64;
     MDKLLDFGFQ NIDLWRSEEM ELVRLLIPSE SAHDTVAALG EVGLLQFKDM NTEKSAFQRT
     YANQVKRCDE MARRLRFFTE QVEKAGLTPT VHSASGKHEL DDLESRLEEL EKELISMNEN
     TERLDRTYNE LVELQVVLEH AGKFFDKAKA SVRADRDYAG VQEPDAPLLE VPGQDKVSRI
     GFVAGTIPAD KVMGFERLLF RATRGNMFLR QGSVGEVKDP ITNETVSKHV FVIFFAGDRS
     RTKIMKICEA FGANRYPFPD DPARQRQMDS EVTARIRELQ TTVDMGLKHR KALLQNLAAN
     LDEWTSLVRR EKAIYHTLNK MNVDVTSKVL VAEAWVPTIA KSDVQRALRE SAENSSTQLN
     VIMQPVVAHG QPPTYFRTNK FTAAFQNIVD SYGVAKYREV NPTVLTLMTF PFLFSVMFGD
     FGHAILMIAF AALLVWKEKQ LAKQDLGDML QLLFGGRYVI LLMGIFSFYL GLIYNEFFSM
     PTVIFGRTKF KCYHGDGSEI VNDFGEPITN TIDPRDCQMV YEGVLKMPPD SAPLVFGVDP
     IWHGRKTELP YLNSMKMKMS ILLGVAHMNF GIINSLYNNL YFRDWLSVWC EFVPQMIFLN
     FIFGYLCILI VIKWCTGKLT DLYHVMIYMF LSPGGGFDDP SQILIPGQPG LQVFLLLVAF
     VAVPWMLLPK PLILKKRHEA LEAAKGQSSV ELTQNYGALA DDEESRHRPA AAAAHGDGHG
     GGHGGGHGDG HGHGGEFNFG EVMVHQMIHT IEFALGAVSN TASYLRLWAL SLAHSQLAGV
     FYDRVLMAGI AANNVGAMII AFFVFACATL GVLMVMESLS AFLHALRLHW VEYQNKFYKG
     DGYKFMPFSF ATLKQLEDAG QL
//
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