ID A8JNM6_DROME Unreviewed; 4189 AA.
AC A8JNM6;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 127.
DE SubName: Full=Ankyrin 2, isoform J {ECO:0000313|EMBL:ABW08487.1};
GN Name=Ank2 {ECO:0000313|EMBL:ABW08487.1,
GN ECO:0000313|FlyBase:FBgn0261788};
GN Synonyms=ank2 {ECO:0000313|EMBL:ABW08487.1}, ank2-L
GN {ECO:0000313|EMBL:ABW08487.1}, CG18025 {ECO:0000313|EMBL:ABW08487.1},
GN CG18227 {ECO:0000313|EMBL:ABW08487.1}, CG18768
GN {ECO:0000313|EMBL:ABW08487.1}, CG32373 {ECO:0000313|EMBL:ABW08487.1},
GN CG32375 {ECO:0000313|EMBL:ABW08487.1}, CG32377
GN {ECO:0000313|EMBL:ABW08487.1}, CG34121 {ECO:0000313|EMBL:ABW08487.1},
GN CG34158 {ECO:0000313|EMBL:ABW08487.1}, CG34416
GN {ECO:0000313|EMBL:ABW08487.1}, CG7462 {ECO:0000313|EMBL:ABW08487.1},
GN CG7493 {ECO:0000313|EMBL:ABW08487.1}, DAnk2
GN {ECO:0000313|EMBL:ABW08487.1}, Dank2 {ECO:0000313|EMBL:ABW08487.1},
GN dank2 {ECO:0000313|EMBL:ABW08487.1}, Dmel\CG42734
GN {ECO:0000313|EMBL:ABW08487.1}, ESTS:149B10S
GN {ECO:0000313|EMBL:ABW08487.1}, SP2523 {ECO:0000313|EMBL:ABW08487.1},
GN sp2523 {ECO:0000313|EMBL:ABW08487.1};
GN ORFNames=CG42734 {ECO:0000313|EMBL:ABW08487.1,
GN ECO:0000313|FlyBase:FBgn0261788}, Dmel_CG42734
GN {ECO:0000313|EMBL:ABW08487.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ABW08487.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:ABW08487.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:ABW08487.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:ABW08487.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:ABW08487.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:ABW08487.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; AE014296; ABW08487.1; -; Genomic_DNA.
DR RefSeq; NP_001097538.1; NM_001104068.2.
DR SMR; A8JNM6; -.
DR DNASU; 38863; -.
DR EnsemblMetazoa; FBtr0303123; FBpp0292242; FBgn0261788.
DR GeneID; 38863; -.
DR UCSC; CG34416-RJ; d. melanogaster.
DR AGR; FB:FBgn0261788; -.
DR CTD; 287; -.
DR FlyBase; FBgn0261788; Ank2.
DR VEuPathDB; VectorBase:FBgn0261788; -.
DR GeneTree; ENSGT00940000167243; -.
DR OrthoDB; 3139942at2759; -.
DR BioGRID-ORCS; 38863; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 38863; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0261788; Expressed in brain and 24 other cell types or tissues.
DR ExpressionAtlas; A8JNM6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0031594; C:neuromuscular junction; IDA:FlyBase.
DR GO; GO:0005886; C:plasma membrane; HDA:FlyBase.
DR GO; GO:0042734; C:presynaptic membrane; IDA:FlyBase.
DR GO; GO:0036062; C:presynaptic periactive zone; IDA:FlyBase.
DR GO; GO:0043195; C:terminal bouton; IDA:FlyBase.
DR GO; GO:0048675; P:axon extension; IMP:FlyBase.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IMP:FlyBase.
DR GO; GO:1900074; P:negative regulation of neuromuscular synaptic transmission; IMP:FlyBase.
DR GO; GO:0007528; P:neuromuscular junction development; IMP:FlyBase.
DR GO; GO:0070050; P:neuron cellular homeostasis; IGI:FlyBase.
DR GO; GO:0045887; P:positive regulation of synaptic assembly at neuromuscular junction; IMP:FlyBase.
DR GO; GO:0007605; P:sensory perception of sound; IMP:FlyBase.
DR GO; GO:0007614; P:short-term memory; IMP:FlyBase.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08317; Death_ank; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF33; ANKYRIN 2, ISOFORM U; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 7.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 24.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 1: Evidence at protein level;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A8JNM6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 43..75
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 76..108
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 109..141
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 142..164
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 204..236
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 237..269
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 270..302
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 303..335
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 336..368
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 369..401
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 402..434
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 435..467
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 468..500
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 501..533
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 534..566
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 567..599
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 600..632
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 633..665
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 666..698
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 699..731
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 732..764
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 928..1085
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1087..1234
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1419..1501
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 862..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1541..1562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1657..1678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1852..1892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1927..1956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2082..2126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2142..2161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2340..2362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2525..2624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2677..2707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2782..2944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3113..3174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3233..3260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3378..3507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3579..3605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3619..3643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3698..3742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3960..3994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4151..4189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1657..1675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2082..2117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2530..2549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2556..2574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2684..2705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2787..2812
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2813..2833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2869..2887
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2905..2935
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3427..3479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3487..3503
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3619..3637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3716..3740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3964..3987
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4153..4169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4170..4189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4189 AA; 460660 MW; 06E4AD3107CA8730 CRC64;
MVTENGAQGD GNTSFLRAAR AGNLERVLEH LKNNIDINTS NANGLNALHL ASKDGHIHVV
SELLRRGAIV DSATKKGNTA LHIASLAGQE EVVKLLLEHN ASVNVQSQNG FTPLYMAAQE
NHDAVVRLLL SNGANQSLAT EDGFTPLAVA MQQGHDKVVA VLLESDTRGK VRLPALHIAA
KKDDVKAATL LLDNDHNPDV TSKSGFTPLH IASHYGNQNI ANLLIQKGAD VNYSAKHNIS
PLHVAAKWGK TNMVSLLLEK GGNIEAKTRD GLTPLHCAAR SGHEQVVDML LERGAPISAK
TKNGLAPLHM AAQGEHVDAA RILLYHRAPV DEVTVDYLTA LHVAAHCGHV RVAKLLLDRN
ADANARALNG FTPLHIACKK NRLKVVELLL RHGASISATT ESGLTPLHVA AFMGCMNIVI
YLLQHDASPD VPTVRGETPL HLAARANQTD IIRILLRNGA QVDARAREQQ TPLHIASRLG
NVDIVMLLLQ HGAQVDATTK DMYTALHIAA KEGQDEVAAV LIENGAALDA ATKKGFTPLH
LTAKYGHIKV AQLLLQKEAD VDAQGKNGVT PLHVACHYNN QQVALLLLEK GASPHATAKN
GHTPLHIAAR KNQMDIATTL LEYGALANAE SKAGFTPLHL SSQEGHAEIS NLLIEHKAAV
NHPAKNGLTP MHLCAQEDNV NVAEILEKNG ANIDMATKAG YTPLHVASHF GQANMVRFLL
QNGANVDAAT SIGYTPLHQT AQQGHCHIVN LLLEHKANAN AQTVNGQTPL HIARKLGYIS
VLDSLKTITK EDETAAAPSQ AEEKYRVVAP EAMHESFMSD SEEEGGEDNM LSDQPYRYLT
VDEMKSLGDD SLPIDVTRDE RMDSNRMTQS AEYASGVPPT IGEEVISPHK TQVYGSSPKA
TVDGVYIANG SGHDEPPHVG RKLSWKSFLV SFLVDARGGA MRGCRHSGVR MIIPSRSTCQ
PTRVTCRYVK PQRTMHPPQL MEGEALASRV LELGPCSTKF IGPVVMEVPH FASLRGKERE
IIILRSDNGE TWREHTIDNS EEIIHDVLQQ CFEPEEIAQL EEQAGNHVCR FVTYDFPQYF
AVVSRIRQEV HAIGPEGGMV SSTVVPQVQA VFPQGALTKK IKVGLQAQPV DPDLTAKLLG
RGVAVSPIVT VEPRRRKFHK AITLSMPAPK AHSQGMINQY SGNTPTLRLL CSITGGPSRA
QWEDVTGSTP LTFVNDCVSF TTTVSARFWL MDCRNISDAT KMATELYKEV IHVPFIAKFV
VFAKKVEPFE AKLRVFCMTD DREDKTLEKH ELYTEVAKSR DVEVLEGKPQ YIEMAGNLVP
VTKSGDQLQV QFKAFRENRL PFTVRVKDQH ADIVGRTLFM KEPKVAKGEP PQQPICILNI
VLPEAVIPDS TTAFSDRVTS AYRTSMFSLS KHQNDHYIGD IRIVDLSNLL GKDWIQLAPE
IGINGEEIDE IINQNTDSIA RQAQSMIRLY KDKPNYDILS LETALKNIGR DDIMKKCKSG
RLSHSREFDE ADLMKNSESV EELVRRESKR IQQINEREEV KYSAEEKEVE ESESDEEAAK
RTVAERREKI VKRLSIERSI PASTQKKEIT REITEIKRKS LIEDKKAHHE SEILMQLPAD
NVIIKTTTVP DQVIKMKMGK MDSTEVSKSE FDKELTHKFK TSGRSSEEED QPSYPDQTDK
IVQDISAAEK KEKDGVTFSR VTTITRQEAR DITEDFLEIE KRSQLPATST TATVHEKFVE
EIKEKTSPLA SVPQETVKEV QQVISEVTEI ASKKVENIIS SFESSKSVDA TTVLPTQPSV
ESTKVSETIK NLEDAKAVSA EQVKTVHVVE SSSIEETIAE FEAKKVKYDF HGGEPKTQIP
KFTRKPSDDS MKPTAAPRAT VESETESVLE TKAEKPISKI PVKTIPTEAQ KVSEVDARKI
TQDFLQGEKL AAEPKPSPAA SKIPKVEPRK SVDKQVDRES KILDDVVAST ATIMTAGLGD
EQLKDQLVDH SEIIAKSETV AEKVTELLDT FHKIEEKVTK SEKTSEISSK VEELVKIEEK
PLSQVQPKED KVAEKVAEVI ETFHKIEEKI TTADARELTR DFLSMEQQNQ LPSMPQAAEK
PLESSLTSTS ASEPESIVTV KPSPPASKIP VVEPRKIVFD ESTKPLIEPE PVKTTEKKPL
NERQLTADFL SMEQQTQLVS EPAKSLVEEV MKSAEQMVEQ PKQQKSLNER QLTEDFLLME
QQTQLPSDIV KPTDKLIDGI ESAAPVGDEA SPFHTPKLTT SVVTQEPQQL ASEYDSDTFG
KQATIPLGDS KIDQGLIAPV SMEPRKSLTD AEFCKSVGET ITKKMSVGVI EISDELKKIE
SEIPHSQTPP PTPSDNKTDK QNEEPELISL ERDYLADTVT TLHTTTESTL ERVSAITKIE
TLHERKVELS NLDTEKISHE IDPVAVLESV PVSFPVASSR NQTEDESETR ARRIDHKIEK
LSTDMDDVSA RFDEAFEMSV PEDEISALQG DFSKLSWDES VSPTTNTMAD MAQNQITPDN
DIQDLIAETG GDLPNSSETD TTPVPPSKES ESKTETEPTV VTNAFTTTSH DTPTPKPRVL
KASSPVSEGT DSTTIPGPVP KPEIPIDISF DANAPVPKPR APIKHTEPFE NLAALAEQSD
SISLRSFELT EDISKTDEPS TELSIRSQLR DIVTTTTVSE DHTESFEPTS EISVDDADTE
KSEGAEKTTS FYIGESSRNV IIKTSTRSAS VTPQEEEAQG EIGIDAKDIS LMKEVSVDSD
EANDVFKEFI TMKPEDPIAM DSKITRQGSE TRNDILEFEN ADKDKTAEQK LSKVTTEESL
TTSTGSSGRA IIEIAPSSSE DPDESSKEIP EIVNTISEKA AASDNFELPL EKSEWETSEK
EIPTEGKPKV VHSPQQPQEA SMKSTLDRFH VDEILAEEQV TDEHSSSDHK SFKDQTPSEL
GSSTVPQEYT FAVESEDISS FIGIPEASMQ TSTLDSTQPP EGLFDTTIKE TLNKQAAMAH
YAQDVFGRGE RRDDHGSLGF ISTGTAEELS SMEEHMAKEE QASLGFISTE TAEDFSSMED
YYSEKLAIAS VVADEVATEK SLTTSTFEEL SSDQSMKPID VVVHRLKTET SPDSINRWSI
PDVDTSSSSE SFHRSFDKTQ SRPLSSDLDN LVTTTGTGTS SDYQTAREFT TTGRTEGTEY
ISAVSTLGSS SLDSQSETSA NLASIDVSEL SETLVASSAE VDAFEAEEMS RLRDLRADDE
DSDESVELPG TAGYPSIEQQ SLMKRSQEMI FKPKTLDDEP LAVQVAQIEE YPKPKEAERT
WGLAYPLEDS KVDSPRESEK GEDILLYHGD PRRSIDESKL ASSLDEGSIL SVSMSSTSNI
DTVVENFDDI IGSAGSSSLT GIEGFQYGHD ESIPSASVPE DATFMLEMES KEHSPQDSNA
STPPGGESKR RGHKRNESIS GDALKNLDKE VALLGEGKES ESESDTDPYE SEYARQFRSP
KERKSKKKKQ AAAEMDHSGE LEKRPFTPSQ LVAEVIVEDS ITEELEAEAA MIEERRPSQN
MQDYSNIPDI MVTEDIKSPI LEEETDEFPE KMLYKVRTEE ELHKASDTSV YQKAKAEEKE
QDFQRRVQEQ YRQKLEELKR AEVGAEYDDR KAPDSPDSFE MVEQPDISDE FVIIEEVAKE
ANEVDLGGQS IKIKPVKYEQ KHDEDVEKII IKSAPADPKL GSQLYKDDLN FEFEESPPTG
ASSSSEQQEE SDSSETAAAN KRWVEMQLTD NQLRYPYDLA GAVLEDIKEE DGEFEVGSSR
ISSFKDSFSS TPEYDVAARR YHSRGEHDDV SMSSLQEFES LEQAISLENR NRTHQGSTDS
SNGSFTRRYV VRHSGSGTAP GDDVSVSSLK DFEGLENACI EAHLIEIKAR EEAALLSRSD
ESNKSNGSDK GATGNVVVTK VTRTVTRTEV VPSSQVESIE ALLKQKLERE EGSVQGRVTD
IGTTELDTKS KIDSQDSEKD SIDSMEISKS HDMMTSSIES FDISKDATTR SDVDSLEIDK
RHSRQESIES FGDEQLDLMT KFVSGGGVTL GDGLTTTTTT TTTSTDADGH EHTVTRVITT
ITNVGGGIQE LPMDESGMSK DVSVDSLNMC VEQTTSSAGT TATYQTSAGN SQMSGSVTSC
ASSTLMEDSF PGVGGMSSSQ MSASFWSHDE STVVEDEGRD LAKKPQQGH
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