ID A8JTW0_9HIV1 Unreviewed; 184 AA.
AC A8JTW0;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:ABO63188.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ABO63188.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ABO63188.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ABO63188.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=100GR63272 {ECO:0000313|EMBL:ABO63188.1};
RX PubMed=17955435; DOI=10.1086/521677;
RA Paraskevis D., Magiorkinis E., Magiorkinis G., Sypsa V., Paparizos V.,
RA Lazanas M., Gargalianos P., Antoniadou A., Panos G., Chrysos G.,
RA Sambatakou H., Karafoulidou A., Skoutelis A., Kordossis T., Koratzanis G.,
RA Theodoridou M., Daikos G.L., Nikolopoulos G., Pybus O.G., Hatzakis A.;
RT "Increasing prevalence of HIV-1 subtype A in Greece: estimating epidemic
RT history and origin.";
RL J. Infect. Dis. 196:1167-1176(2007).
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DR EMBL; EF448729; ABO63188.1; -; Genomic_DNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF5; RIBONUCLEASE H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW ECO:0000313|EMBL:ABO63188.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..171
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABO63188.1"
FT NON_TER 184
FT /evidence="ECO:0000313|EMBL:ABO63188.1"
SQ SEQUENCE 184 AA; 21873 MW; CDEA87C492E47F25 CRC64;
QKKESTKXRK LVDLRELNKR IEDFWEXQLG IPHPEGXTKK KLVXVLDVGH GYFSVTLDKE
FRKYTAFTKP SINNETPGIR YQYNVLPQGW KGSPAIFQCS MTKILEPFRK QNPDIVIYQY
MDDLYVGSDL EIEQHRTKIE ELRQHLLRWG FTTPDKKHQK EPPFLWMGYE LHPDKWTVQP
IELP
//
