ID A8KXT9_FRASN Unreviewed; 1071 AA.
AC A8KXT9;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE SubName: Full=Erythronolide synthase {ECO:0000313|EMBL:ABW12873.1};
DE EC=2.3.1.94 {ECO:0000313|EMBL:ABW12873.1};
GN ORFNames=Franean1_3471 {ECO:0000313|EMBL:ABW12873.1};
OS Frankia sp. (strain EAN1pec).
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW12873.1};
RN [1] {ECO:0000313|EMBL:ABW12873.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EAN1.pec {ECO:0000313|EMBL:ABW12873.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N.,
RA Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T.,
RA Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Kim E., Rawnsley T., Niemann J., Benson D.R., Huang Y.,
RA Mastronunzio J., Bassi C.A., Tisa L.S., Richardson P.;
RT "Complete sequence of Frankia sp. EAN1pec.";
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP000820; ABW12873.1; -; Genomic_DNA.
DR AlphaFoldDB; A8KXT9; -.
DR STRING; 298653.Franean1_3471; -.
DR KEGG; fre:Franean1_3471; -.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_16_6_11; -.
DR OMA; INGMPLM; -.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0047879; F:erythronolide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR036299; Polyketide_synth_docking_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF101173; Docking domain B of the erythromycin polyketide synthase (DEBS); 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:ABW12873.1};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABW12873.1}.
FT DOMAIN 39..465
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 994..1069
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 75..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 10..37
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1071 AA; 112426 MW; 0D61487B43FD9169 CRC64;
MTDQAVASTE DRLRDYLRRA TADLRQARRR IRELDARVHE PIAIVGMGCR LPGGVDSPEA
LWRLLDEERD AIADLPTDRG WDPERLYDPD PDRPGTTYAR EGGFLADAGG FDAPFFGIGP
REATASDPQH RQLLEVAYET LEYAGIAPDS LHGTRTGVYA GVVSQAYVPP PERVPASFEG
HLMTGNATSV ASGRVAYHLG LEGPALTLDT ACSSSLVAMH LAARALQRGE CDLALAGGVT
VMATPVLLVE FSRQRGLSPD GRCKAFAAAA DGTGFAEGVG LVALERLSDA RRAGRRILAV
LRGSAVNSDG ASNGLTAPNG VSQERVIRQA LADARLAPQQ VDVVEAHGTG TRLGDPIEAQ
ALLATYGQGR PAGEPLWLGS LKSNIGHTQA AAGIAGVIKM ILAMRHDRLP RTLHVDEPTP
HVDWAGGDVQ LLTEARRWQR GDRPRRAAVS SFGISGTNAH LVLEEPPASD EPAAETEPGL
DSDEPATGGQ AGPAAGTGDT RPPAADPAAA PWVLSGRTEA ALRAAAGRLH ERLDADPGLD
PAEVGRVLAV GRTAHPHRAA VLPGSNRRRL EALAALAGGR PGGLVAPGGP GGRTAFLFTG
QGSQRPGMGR HLYANRPVFA AALDEVFAAF EPLLDRRLPD LMFTEPGTDE AALLDRTEYA
QPALFALETA LYRLLVDLGP EPDLVAGHSL GGLTAGHVAG LLSLADAAAL VAARGRLMQA
QPTGGLMAAC EATADEIEPL LAAQDGQDGQ VSLAAVNGPR AVVVSGDAAA VARVTAAVAA
RGGRTRTLRV SHAFHSAHMD GALAPFREVV AGLRFQPPVL DVVSELTGRP ASFEELRDPD
YWVRQLRSPV RFADAVATLH AAGATTFLEV GPDAVLTPMV ADCLPVGAGA AGAGQVVAVP
ALVRDRPEEQ VLATALVWRH VRGADVRWDA WFGPAAGPPP HLPTYPFEHR RYWWPAEVVA
APAGPRPVTA EVAEVPAADQ ADQADPPVAA DRGEVLLALV REHAAEVLGH PDPDSIGADD
NFLEIGFSSF TALEVRNRLC EATGLTLPAV LLYDHPTPTA VVRFLEESLV A
//