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Database: UniProt
Entry: A8KXT9_FRASN
LinkDB: A8KXT9_FRASN
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ID   A8KXT9_FRASN            Unreviewed;      1071 AA.
AC   A8KXT9;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   24-JAN-2024, entry version 87.
DE   SubName: Full=Erythronolide synthase {ECO:0000313|EMBL:ABW12873.1};
DE            EC=2.3.1.94 {ECO:0000313|EMBL:ABW12873.1};
GN   ORFNames=Franean1_3471 {ECO:0000313|EMBL:ABW12873.1};
OS   Frankia sp. (strain EAN1pec).
OC   Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW12873.1};
RN   [1] {ECO:0000313|EMBL:ABW12873.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EAN1.pec {ECO:0000313|EMBL:ABW12873.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N.,
RA   Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T.,
RA   Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Rawnsley T., Niemann J., Benson D.R., Huang Y.,
RA   Mastronunzio J., Bassi C.A., Tisa L.S., Richardson P.;
RT   "Complete sequence of Frankia sp. EAN1pec.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP000820; ABW12873.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8KXT9; -.
DR   STRING; 298653.Franean1_3471; -.
DR   KEGG; fre:Franean1_3471; -.
DR   eggNOG; COG3321; Bacteria.
DR   HOGENOM; CLU_000022_16_6_11; -.
DR   OMA; INGMPLM; -.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0047879; F:erythronolide synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR036299; Polyketide_synth_docking_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SMART; SM01294; PKS_PP_betabranch; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF101173; Docking domain B of the erythromycin polyketide synthase (DEBS); 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000313|EMBL:ABW12873.1};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABW12873.1}.
FT   DOMAIN          39..465
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          994..1069
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          75..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          466..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          10..37
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1071 AA;  112426 MW;  0D61487B43FD9169 CRC64;
     MTDQAVASTE DRLRDYLRRA TADLRQARRR IRELDARVHE PIAIVGMGCR LPGGVDSPEA
     LWRLLDEERD AIADLPTDRG WDPERLYDPD PDRPGTTYAR EGGFLADAGG FDAPFFGIGP
     REATASDPQH RQLLEVAYET LEYAGIAPDS LHGTRTGVYA GVVSQAYVPP PERVPASFEG
     HLMTGNATSV ASGRVAYHLG LEGPALTLDT ACSSSLVAMH LAARALQRGE CDLALAGGVT
     VMATPVLLVE FSRQRGLSPD GRCKAFAAAA DGTGFAEGVG LVALERLSDA RRAGRRILAV
     LRGSAVNSDG ASNGLTAPNG VSQERVIRQA LADARLAPQQ VDVVEAHGTG TRLGDPIEAQ
     ALLATYGQGR PAGEPLWLGS LKSNIGHTQA AAGIAGVIKM ILAMRHDRLP RTLHVDEPTP
     HVDWAGGDVQ LLTEARRWQR GDRPRRAAVS SFGISGTNAH LVLEEPPASD EPAAETEPGL
     DSDEPATGGQ AGPAAGTGDT RPPAADPAAA PWVLSGRTEA ALRAAAGRLH ERLDADPGLD
     PAEVGRVLAV GRTAHPHRAA VLPGSNRRRL EALAALAGGR PGGLVAPGGP GGRTAFLFTG
     QGSQRPGMGR HLYANRPVFA AALDEVFAAF EPLLDRRLPD LMFTEPGTDE AALLDRTEYA
     QPALFALETA LYRLLVDLGP EPDLVAGHSL GGLTAGHVAG LLSLADAAAL VAARGRLMQA
     QPTGGLMAAC EATADEIEPL LAAQDGQDGQ VSLAAVNGPR AVVVSGDAAA VARVTAAVAA
     RGGRTRTLRV SHAFHSAHMD GALAPFREVV AGLRFQPPVL DVVSELTGRP ASFEELRDPD
     YWVRQLRSPV RFADAVATLH AAGATTFLEV GPDAVLTPMV ADCLPVGAGA AGAGQVVAVP
     ALVRDRPEEQ VLATALVWRH VRGADVRWDA WFGPAAGPPP HLPTYPFEHR RYWWPAEVVA
     APAGPRPVTA EVAEVPAADQ ADQADPPVAA DRGEVLLALV REHAAEVLGH PDPDSIGADD
     NFLEIGFSSF TALEVRNRLC EATGLTLPAV LLYDHPTPTA VVRFLEESLV A
//
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