ID A8L609_FRASN Unreviewed; 2816 AA.
AC A8L609;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:ABW14966.1};
GN ORFNames=Franean1_5615 {ECO:0000313|EMBL:ABW14966.1};
OS Frankia sp. (strain EAN1pec).
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW14966.1};
RN [1] {ECO:0000313|EMBL:ABW14966.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EAN1.pec {ECO:0000313|EMBL:ABW14966.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N.,
RA Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T.,
RA Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Kim E., Rawnsley T., Niemann J., Benson D.R., Huang Y.,
RA Mastronunzio J., Bassi C.A., Tisa L.S., Richardson P.;
RT "Complete sequence of Frankia sp. EAN1pec.";
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP000820; ABW14966.1; -; Genomic_DNA.
DR STRING; 298653.Franean1_5615; -.
DR KEGG; fre:Franean1_5615; -.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG2070; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_30_1_11; -.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.20.20.70; Aldolase class I; 2.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 765..1209
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 250..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1719..1739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2150..2248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2269..2294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2816 AA; 285648 MW; 59E40787FF52C421 CRC64;
MSSSFSAQPR PVAVEPGDRD LVVVVSPFGE PAPHLVAAVG HAGGLGILDL GLDPARGRES
MAAAAAWSTA PFGVRVPEGC PIGSGDLPAG VDTVLLGVNA PWTVAEGAGR GRRVLVEVLS
VADAMGALES GAAGLVARGS EAGGRVGDLT TFTLLQHLIA AKATRRDGTV APVWAAGGIG
PATAAAAIAG GAAGVVLDSQ LALVREMELP TEIAAAVRAM DGSETALIEG HRVYVRPDLP
VARLVGWPAG AGAPKDGDEP ATDFRDTGGE LASDGALTSA APAATAPAAT ASTVGGERGP
VALRLGGRDL REQLLPVGQD GALAADLADR YVSASAVVRA VRESVRTALD SAARHRPLAP
GSPFAAARGL RYPVAQGPMT RVSDRARFAR SVADAGGLPF LALALLDGAA TRTLLTETAE
LLGDSPWGVG ILGFAPPEVR AAQLEAVHEV RPPCALIAGG RPAQSAPLEA AGIDTFLHVP
SPGLLDRFLT DGARKFVFEG RECGGHVGPR ASFSLWEAQI TRLLAFARAA GDEPGSLRDV
HVLFAGGIHD ATSAAMVAAA AAPLADRGAR VGVLMGTAYL FTEEAVADGA IMPGFQEAAI
GATRTVLLET SPGHATRCVE SEFVHTFLRR REELTAAGVA RKQMWAELES LNLGRLRIAS
RGVRREGGQL VEVGPREQAT DGMFMIGQVA ALRSDRTTIG RLHAEVTEQA TALVAERAAE
RAGGPTGQVA ALPAQRTAGS TDAADGDQAE RAARSVAAVR EAARSLDIAI VGMSAVFPRA
SDEKDYWANV VGGVDAITEV SPERWDANLY YDPESVVKDA GRRTPSKWGG FLPRIPFDAL
AYGIPPRSLR SIDPGQLLAL EVAARAIRDA GYENRPFDRR RTSVVFGAES GSDLSTTYGF
RSAHRAWVGE LPAELEELLP ELDEDSFPGM LANVIAGRVA NRLDLGGLNF TVDAACASSL
AALDAACKEL SAGASDMVLC GGVDTHSSVH DFLLFASVHA LSPGGRCRSF DSGADGTSLG
EGVAVVVLKR LADAQRDGDR IRAVIRSVAG SSDGRALGLT APRKAGQVIA LERAYATAGI
SPSEVGMLEA HATGTVVGDR TELATLTEVF TEHGAAVGQC AVGSVKSQIG HTKCAAGLAG
LVKVARAVET GVRPPTLHMD RPNPYWERES SPFYFDDQAR PWIAPAGRRH AGLSAFGFGG
TNFHVVVSAY DKAPEPAHGL DRWPAELFVI RGRDRAAALR RLDRLAELVR ANEEAGRPYH
LRDLARTAAE ERGGPVRIAF VVDELDDLAA ALDRAREPRS DSRLGVFVHA EDEAGAAGAT
AGAGTSAEGV GAGSVAFLFP GQGSQRPGML ADLFVAFPRL RALLELAPDV AATVFPPAAF
SDTERTAQAA ALTDTRAAQP ALGMAGLAVH DILAGLKIRP DHVAGHSYGE LVALCAAGAY
DRADLVRLSR ARADAILAAA GGDPGTMAAV SATADQIRDV LGAPAADGTV AGVALANQNA
PRQTVISGPT ADVDAAVGRL KDAGLSARRI PVACAFHSPV IAGAAQALAG ELEATPVDDL
TLPVWSNTTA APYPRTPDGT RATLAGQVAA PVRFVEQIEA MYAAGVRVFV ETGPGRVLSQ
LTAKILAGRP HRVVATDAPG EHGLRRLLLA VAELAAAGVE MDPSLLFAGR DTRTVPADGM
PRRPGWLIDG AYVRTGQGGY LPGGLRPARR VPPVAPAVGT EPAMAETGGS GDTGRQDGPG
AWRVLAPGPA VGGPVVGGPV VAGGSAGGTP VDGPQMMNGH ANGHRDGWYP GPNGSGPALA
AAGTSGEQVV DSRPAAPAPV ASPADAAVLE FLRTGRDLVA AQRDVLLTYL GGTAAAPVEH
GAGRWTPAAT LPAPAAPAAV MPAAAPAVTA APARPAVAAS APAMPAPVVA MPAAVEAGAL
VAAVPAAVVA GVSAAAGLSV EAVADAVVGV IADLTGYPVE MLEPDLDLEA DLSIDSIKRT
EILGELAGRV GLAGVGAGDV DESVVEELAA VKTVRGIVSW IVEHQSTDQA AGTAPAVLPV
SAPLAAADGS APAGGPSAGL SVEAVADAVV GVIADLTGYP VEMLEPDLDL EADLSIDSIK
RTEILGELAG RVGLAGVGAG DVDESVVEEL AAVKTVRGIV SWIVEHQSTD QAAGPAITAG
DGTGHGVGPG AGGDAGWAGP GQVEVPEQSR AERRSADGAG GRGQSGGPWA GSAAVPASAV
PATAAATAAA RPPAPGTRNG GGVPSAAAAP ATAVPVPAGV PVMSAPLGAP AGAPPRPASA
PESWGVRSAP RGSTDPVFAE RVPLRRFVVE STELAPLPSW DDIVAAGRAA VLDGARFAVV
DGGLGIGLAL STLLEQAGAQ VRIISANDAA LGELVASGIA ADGLFWAASA EGSAGPVGGL
PAAFPALRAA ALAGIRRLVA VTGLGGDLGR NGEIGDPGSG AGMAGLVRTL ARELPDLLIR
LVDVHPKAQP RRIAESLLAE MLDPAAPVVV GYRDGVRIAP ELRMSDLVAV TAGPGSAAAG
SPRAAAAPPG LDRSGVVLLT GGARGITART ALALAGATGC AVELVGRTPV PDAPEDEATA
GALDAPALRR ALIATGVRRP AEIEARIGRI LAEREIRATL AALREVAASV RYHPIDVRDV
TAVAGVVADV YARHGRLDGV VHGAGVLEDR LLRDKSPESF DRVFRTKVDG ARALLDALRP
DVGFVVLFGS VAGVFGNRGQ VDYAAANDAL DALAHTASAR FAGRVVSVDW GPWGTDTAAG
RGMVSAELSR EYARRGIGLI DPGEGVAALL RELGEPVADA PTQVVYMCAG VGSFDG
//
