ID A8LBG8_FRASN Unreviewed; 864 AA.
AC A8LBG8;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Drug exporter of the RND superfamily-like protein {ECO:0000313|EMBL:ABW11015.1};
GN ORFNames=Franean1_1576 {ECO:0000313|EMBL:ABW11015.1};
OS Frankia sp. (strain EAN1pec).
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW11015.1};
RN [1] {ECO:0000313|EMBL:ABW11015.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EAN1.pec {ECO:0000313|EMBL:ABW11015.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N.,
RA Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T.,
RA Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Kim E., Rawnsley T., Niemann J., Benson D.R., Huang Y.,
RA Mastronunzio J., Bassi C.A., Tisa L.S., Richardson P.;
RT "Complete sequence of Frankia sp. EAN1pec.";
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP000820; ABW11015.1; -; Genomic_DNA.
DR AlphaFoldDB; A8LBG8; -.
DR STRING; 298653.Franean1_1576; -.
DR KEGG; fre:Franean1_1576; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_1_1_11; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 3.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 737..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..368
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 468..597
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 689..773
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 619..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 88433 MW; BC5C8B4902A6045E CRC64;
MCARHRWIVV ALWVAGLAAL LVFVRDSGAR FNTDVAVPGT DSARAMDLVS EVVPGGGLPD
TESIVLHARR GTVDDPLVRE QIAAMAAELG KLPKVGGVID PFNPAGAVVL GIEPISANRR
TAVTSVIMKG SALNPDRAAA RRLIDTARAY DGPDLQVEAA GPGATALSAT TISPRPIIIA
LVAALLLLGV TLRSRGAVAV CAATSAVATV AALGAIVLIS HTITTTAFAP LLAAVVAAGT
SLGGAVVVVH RAQSALREGV GPVEAAAQAT ARAGFAVAYG GFCVTLAMDG VALLGLSFFD
GVALGTAAAG AATGLVILTL LPALLGLSGP RLLGWTERQH LTTSGRGLPH RPGLRAWWAR
QVDRRPAAMA LAAGLGLVLL AVPAVTLNLG GADDGAESTS MSTRRAYDLL SADFFPGLNG
PMLVAVERGD GPSAVPVADV VSAIAKTPGV VKAAVNLEKA DAGLAVIRIA PREGPRSPAA
VDLLHRLRDD VIPRAVAGTG SRVYIGGSTA LFVDMAADFR GATTLFLLVI LLVVGVLGLL
ILRSVEIAAA LAVTSVLAVL AAAGVLAILF QTDLLATALG LETGPVEPSM LVLVLVAVFG
LLPGLNLSLL VRLMEPADRA GNEPPTRDAE GTGDTQNAEG AEGAESTRNT GGTRRTRRRR
RADTGPVRRR SAGSRLRGRR GGTSGPIRRH RTDTTPIRRG HADVGHVMLT MNLVMLFLFM
AIAAQPSRTM KVIGCGLATG MAIDAFVLRA TLLPAVLHLL RPTRPGSPTR RTSATGDGTG
DGRRAARDGG RATGDGGRAT RSARAGRRRA RPGQPSTPGP AGGSPRPVTR VAAFTPTAFG
EESAPRRDGT GRVAQPSPPR HPAG
//
