ID   A8LNN2_DINSH            Unreviewed;       357 AA.
AC   A8LNN2;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   SubName: Full=3-isopropylmalate dehydrogenase {ECO:0000313|EMBL:ABV95126.1};
DE            EC=1.1.1.85 {ECO:0000313|EMBL:ABV95126.1};
GN   Name=leuB {ECO:0000313|EMBL:ABV95126.1};
GN   OrderedLocusNames=Dshi_3393 {ECO:0000313|EMBL:ABV95126.1};
OS   Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Dinoroseobacter.
OX   NCBI_TaxID=398580 {ECO:0000313|EMBL:ABV95126.1, ECO:0000313|Proteomes:UP000006833};
RN   [1] {ECO:0000313|Proteomes:UP000006833}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16493 / NCIMB 14021 / DFL 12
RC   {ECO:0000313|Proteomes:UP000006833};
RX   PubMed=19741735; DOI=10.1038/ismej.2009.94;
RA   Wagner-Dobler I., Ballhausen B., Berger M., Brinkhoff T., Buchholz I.,
RA   Bunk B., Cypionka H., Daniel R., Drepper T., Gerdts G., Hahnke S., Han C.,
RA   Jahn D., Kalhoefer D., Kiss H., Klenk H.P., Kyrpides N., Liebl W.,
RA   Liesegang H., Meincke L., Pati A., Petersen J., Piekarski T.,
RA   Pommerenke C., Pradella S., Pukall R., Rabus R., Stackebrandt E., Thole S.,
RA   Thompson L., Tielen P., Tomasch J., von Jan M., Wanphrut N., Wichels A.,
RA   Zech H., Simon M.;
RT   "The complete genome sequence of the algal symbiont Dinoroseobacter shibae:
RT   a hitchhiker's guide to life in the sea.";
RL   ISME J. 4:61-77(2010).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR   EMBL; CP000830; ABV95126.1; -; Genomic_DNA.
DR   RefSeq; WP_012180052.1; NC_009952.1.
DR   AlphaFoldDB; A8LNN2; -.
DR   STRING; 398580.Dshi_3393; -.
DR   KEGG; dsh:Dshi_3393; -.
DR   eggNOG; COG0473; Bacteria.
DR   HOGENOM; CLU_031953_0_1_5; -.
DR   OrthoDB; 9767905at2; -.
DR   Proteomes; UP000006833; Chromosome.
DR   GO; GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   PANTHER; PTHR43275; D-MALATE DEHYDROGENASE [DECARBOXYLATING]; 1.
DR   PANTHER; PTHR43275:SF1; D-MALATE DEHYDROGENASE [DECARBOXYLATING]; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR   PROSITE; PS00470; IDH_IMDH; 1.
PE   4: Predicted;
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Oxidoreductase {ECO:0000313|EMBL:ABV95126.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006833}.
FT   DOMAIN          5..353
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   357 AA;  37952 MW;  E688BC73671CA927 CRC64;
     MQSFSITVFD GDGIGPEIMA PTLGLLRKLA GTAATYDLNF DSHPMGAGHY AQTGQALPRA
     SLDAARASDA ILLSAMGLPD IRYPDGTEIT PQIDIRIALD LYAGVRPVRI VPGHPTPLHA
     PGPVDFVLIR ESTEGLFHTK GKGTVTKDHA TETLQITRDT SEKLFRFAFA LAAQRKASGR
     GEGRVTCVDK ANVFRAFAFF REIFDAEAAR HPDLIADHAY VDAMALWMVT RPQTFDVMVT
     ENMFGDILSD LGAGLMGGLG LAPSADIGDD NAVFQPCHGT APDIAGRGIA NPLAMILSAA
     MMLDWLALRG QNAELATDGQ RLREAVEAVL TEGRVLTRDL GGNASTEEAA AAVAAKL
//