ID   A8LUP2_SALAI            Unreviewed;       382 AA.
AC   A8LUP2;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   RecName: Full=Nuclease SbcCD subunit D {ECO:0000256|ARBA:ARBA00013365, ECO:0000256|RuleBase:RU363069};
GN   Name=sbcD {ECO:0000256|RuleBase:RU363069};
GN   OrderedLocusNames=Sare_1497 {ECO:0000313|EMBL:ABV97395.1};
OS   Salinispora arenicola (strain CNS-205).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Salinispora.
OX   NCBI_TaxID=391037 {ECO:0000313|EMBL:ABV97395.1};
RN   [1] {ECO:0000313|EMBL:ABV97395.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNS-205 {ECO:0000313|EMBL:ABV97395.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K., Jenkins C.,
RA   Udwary D., Xiang L., Gontang E., Richardson P.;
RT   "Complete sequence of Salinispora arenicola CNS-205.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: SbcCD cleaves DNA hairpin structures. These structures can
CC       inhibit DNA replication and are intermediates in certain DNA
CC       recombination reactions. The complex acts as a 3'->5' double strand
CC       exonuclease that can open hairpins. It also has a 5' single-strand
CC       endonuclease activity. {ECO:0000256|RuleBase:RU363069}.
CC   -!- SUBUNIT: Heterodimer of SbcC and SbcD. {ECO:0000256|ARBA:ARBA00011322,
CC       ECO:0000256|RuleBase:RU363069}.
CC   -!- SIMILARITY: Belongs to the SbcD family. {ECO:0000256|ARBA:ARBA00010555,
CC       ECO:0000256|RuleBase:RU363069}.
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DR   EMBL; CP000850; ABV97395.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8LUP2; -.
DR   STRING; 391037.Sare_1497; -.
DR   KEGG; saq:Sare_1497; -.
DR   PATRIC; fig|391037.6.peg.1522; -.
DR   eggNOG; COG0420; Bacteria.
DR   HOGENOM; CLU_038045_3_0_11; -.
DR   OrthoDB; 9773856at2; -.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00840; MPP_Mre11_N; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041796; Mre11_N.
DR   InterPro; IPR004593; SbcD.
DR   InterPro; IPR026843; SbcD_C.
DR   NCBIfam; TIGR00619; sbcd; 1.
DR   PANTHER; PTHR30337; COMPONENT OF ATP-DEPENDENT DSDNA EXONUCLEASE; 1.
DR   PANTHER; PTHR30337:SF0; NUCLEASE SBCCD SUBUNIT D; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF12320; SbcD_C; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   3: Inferred from homology;
KW   DNA recombination {ECO:0000256|RuleBase:RU363069};
KW   DNA replication {ECO:0000256|RuleBase:RU363069};
KW   Endonuclease {ECO:0000256|RuleBase:RU363069};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|RuleBase:RU363069};
KW   Hydrolase {ECO:0000256|RuleBase:RU363069};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|RuleBase:RU363069}.
FT   DOMAIN          1..98
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
FT   DOMAIN          281..360
FT                   /note="Nuclease SbcCD subunit D C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12320"
SQ   SEQUENCE   382 AA;  41308 MW;  4697DDB736BB4B5B CRC64;
     MKILHTSDWH VGKVLKGRSR AEEHKAVLAG VIEVARRERP DLVVVAGDLY DTAAPTPEAT
     RLVTRALTAL RRTGADVVAI GGNHDNGAAL DALRPWAEAA GITLRGSVRE DPDEHVIDGT
     TAGGERWRLA ALPFLSQRYA VRAVEMYELT AAEANQTYAD HLGRILTRLT EGFAEPDRVH
     LVTAHLTVVG AATGGGERDA HTVLGYAVPA TVFPGTAHYV ALGHLHRAQQ VQGGCPIRYS
     GSPLAVDFGE QENVPSVTVV EVTATTAAQV REVPIPAAAS LRTVRGTLAQ LAEIEAPDAW
     LRVYVREQPR AGLREEVQEL FPRALEIRID PELVPASGSG TRIAQRAGRS PRELFGDYLD
     GRGHTDDDVR GLFDELFEEV EH
//