ID   A8M0K4_SALAI            Unreviewed;       536 AA.
AC   A8M0K4;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   RecName: Full=Methionyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030904};
GN   OrderedLocusNames=Sare_2149 {ECO:0000313|EMBL:ABV98014.1};
OS   Salinispora arenicola (strain CNS-205).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Salinispora.
OX   NCBI_TaxID=391037 {ECO:0000313|EMBL:ABV98014.1};
RN   [1] {ECO:0000313|EMBL:ABV98014.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNS-205 {ECO:0000313|EMBL:ABV98014.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K., Jenkins C.,
RA   Udwary D., Xiang L., Gontang E., Richardson P.;
RT   "Complete sequence of Salinispora arenicola CNS-205.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-
CC         methionyl-tRNA(Met); Xref=Rhea:RHEA:13481, Rhea:RHEA-COMP:9667,
CC         Rhea:RHEA-COMP:9698, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57844, ChEBI:CHEBI:78442, ChEBI:CHEBI:78530,
CC         ChEBI:CHEBI:456215; EC=6.1.1.10;
CC         Evidence={ECO:0000256|ARBA:ARBA00001234};
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|RuleBase:RU363039}.
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DR   EMBL; CP000850; ABV98014.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8M0K4; -.
DR   STRING; 391037.Sare_2149; -.
DR   KEGG; saq:Sare_2149; -.
DR   PATRIC; fig|391037.6.peg.2174; -.
DR   eggNOG; COG0143; Bacteria.
DR   HOGENOM; CLU_009710_10_1_11; -.
DR   OrthoDB; 9810191at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006418; P:tRNA aminoacylation for protein translation; IEA:InterPro.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 2.20.28.20; Methionyl-tRNA synthetase, Zn-domain; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR023458; Met-tRNA_ligase_1.
DR   InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR   InterPro; IPR029038; MetRS_Zn.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR45765; METHIONINE--TRNA LIGASE; 1.
DR   PANTHER; PTHR45765:SF1; METHIONINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR   Pfam; PF09334; tRNA-synt_1g; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363039};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363039};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363039}.
FT   DOMAIN          10..396
FT                   /note="Methionyl/Leucyl tRNA synthetase"
FT                   /evidence="ECO:0000259|Pfam:PF09334"
SQ   SEQUENCE   536 AA;  58367 MW;  DAAF69CB51FCCAAC CRC64;
     MTADPHRPAV IIAATPTPNG DLHLGHLAGP YLAADVYARH LRMSGRPVVY TTCTDDSQSY
     VLTTARRQGV PPRRLAATAA TAIARSLDAV GISTAGLPPT GDTYRGTVLD FVGQLHAAGR
     FRQRRVRLPY ARHAGMYLYD GLLSGTCPTC LSDSSGGVCE ACGHPNTFDD LLDPRYSLDP
     DDPVEPRVAD VLVLPAEDYR GRLAEYYARH TPRWRPHARR LVNELLARPL PDIPVTVPGS
     WGIPAPFAQT PGQVLYPWIE AMPASIYSTW WSRSPRGATG GNIDAPWRAE TDTELVYFHG
     YDNVYHWGLV DLVLLLAHGD RYVLPAANVC NEFYELAGAK FSTSRDHLVH APEVLAEVPR
     DLLRFYLALT APEYQRSTFD RAALPSVTQT RLVEPWNRLS RALDRALDAS SMPARLPTDE
     AGRRRAAIVA DRFRTWYGLP EFSIRQAADT LSTQVDRLAR QAEVLTGDPT DTGGLVLQVR
     ALLAGAAPLL VDTAAAAAAS GWESGDATAP STTVAALRLP PLAGVRAPQD GRLPVR
//