ID A8NAX6_COPC7 Unreviewed; 500 AA.
AC A8NAX6;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Glycosyl hydrolase family 30 TIM-barrel domain-containing protein {ECO:0000259|Pfam:PF02055};
GN ORFNames=CC1G_07029 {ECO:0000313|EMBL:EAU89877.2};
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Psathyrellaceae; Coprinopsis.
OX NCBI_TaxID=240176 {ECO:0000313|EMBL:EAU89877.2, ECO:0000313|Proteomes:UP000001861};
RN [1] {ECO:0000313|EMBL:EAU89877.2, ECO:0000313|Proteomes:UP000001861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003
RC {ECO:0000313|Proteomes:UP000001861};
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA Burns C., Canback B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA Kues U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.J.,
RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 30 family.
CC {ECO:0000256|ARBA:ARBA00005382, ECO:0000256|RuleBase:RU361188}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAU89877.2}.
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DR EMBL; AACS02000009; EAU89877.2; -; Genomic_DNA.
DR RefSeq; XP_001831978.2; XM_001831926.2.
DR AlphaFoldDB; A8NAX6; -.
DR GeneID; 6008460; -.
DR KEGG; cci:CC1G_07029; -.
DR VEuPathDB; FungiDB:CC1G_07029; -.
DR eggNOG; KOG2566; Eukaryota.
DR HOGENOM; CLU_014379_2_0_1; -.
DR InParanoid; A8NAX6; -.
DR OMA; FGGIAWH; -.
DR OrthoDB; 5487508at2759; -.
DR Proteomes; UP000001861; Unassembled WGS sequence.
DR GO; GO:0004348; F:glucosylceramidase activity; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR001139; Glyco_hydro_30.
DR InterPro; IPR033453; Glyco_hydro_30_TIM-barrel.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR11069; GLUCOSYLCERAMIDASE; 1.
DR PANTHER; PTHR11069:SF23; LYSOSOMAL ACID GLUCOSYLCERAMIDASE; 1.
DR Pfam; PF02055; Glyco_hydro_30; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361188};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361188};
KW Reference proteome {ECO:0000313|Proteomes:UP000001861};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..500
FT /note="Glycosyl hydrolase family 30 TIM-barrel domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002727175"
FT DOMAIN 73..330
FT /note="Glycosyl hydrolase family 30 TIM-barrel"
FT /evidence="ECO:0000259|Pfam:PF02055"
SQ SEQUENCE 500 AA; 54666 MW; 234B87F3350A0D53 CRC64;
MLSLHVRLAG IASILATGVA SQQIWDIWQT TWDRSRLFTS VGPPAPINFV QPGPIGEANI
VVDDGARFQE MLGFGASLTD SSATVLNNLK VRLLNRNSGN YWNVMRTMFN PDSAGLNYIR
VPIGASDFSA SSYSLNDVSG DTSMSRFDMG KVPSQVISVL RDIQGMNNQL KVHLVAWSPP
GWMKSGGSMN GGSLLPQYSD AYALYLLKSV QGFRAQGFPV HAVSVQNEPQ HTNPTYPTCS
MTPDVEARIA VKLRSLLDSS GLGQVKVVGY DHNWNNANSY PVDLVTQAGD AVSGVAFHCY
EGPVSNQASF QRRFPNKDIY FTECTGTYGS DWWSDIKWYM DNLWIGSVER FSRTGLMWNI
ALDGAGNPKL PGTTSCGGPG CRPLVTVNND GSYTFNQEFY AMAQASKAVT PKDPNGPFGQ
RIGVSVEGSK GWALRATAFA TRRSSPGEWT RYSMVVLNWD DSANSGWNPK PVRATISFRG
MQATYVFPVG VTTLWWYAPG
//
