GenomeNet

Database: UniProt
Entry: A8NQK2_COPC7
LinkDB: A8NQK2_COPC7
Original site: A8NQK2_COPC7 
ID   A8NQK2_COPC7            Unreviewed;       813 AA.
AC   A8NQK2;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 2.
DT   24-JAN-2024, entry version 70.
DE   RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
GN   ORFNames=CC1G_03398 {ECO:0000313|EMBL:EAU86187.2};
OS   Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS   (Inky cap fungus) (Hormographiella aspergillata).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricineae; Psathyrellaceae; Coprinopsis.
OX   NCBI_TaxID=240176 {ECO:0000313|EMBL:EAU86187.2, ECO:0000313|Proteomes:UP000001861};
RN   [1] {ECO:0000313|EMBL:EAU86187.2, ECO:0000313|Proteomes:UP000001861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003
RC   {ECO:0000313|Proteomes:UP000001861};
RX   PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA   Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA   Burns C., Canback B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA   Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA   Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA   Kues U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.J.,
RA   Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA   Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA   Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA   Zolan M.E., Pukkila P.J.;
RT   "Insights into evolution of multicellular fungi from the assembled
RT   chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAU86187.2}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AACS02000008; EAU86187.2; -; Genomic_DNA.
DR   RefSeq; XP_001835616.2; XM_001835564.2.
DR   AlphaFoldDB; A8NQK2; -.
DR   STRING; 240176.A8NQK2; -.
DR   GeneID; 6012151; -.
DR   KEGG; cci:CC1G_03398; -.
DR   VEuPathDB; FungiDB:CC1G_03398; -.
DR   eggNOG; KOG3417; Eukaryota.
DR   HOGENOM; CLU_347141_0_0_1; -.
DR   InParanoid; A8NQK2; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000001861; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF341; PROTEIN SON OF SEVENLESS; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001861}.
FT   DOMAIN          580..812
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          326..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        330..358
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        362..378
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   813 AA;  92375 MW;  856D53235D1CD8A0 CRC64;
     MPLFNRASNF TINGGTFNDF SREVVIHHHW HYDSHRTVQQ APIPVERHAS APITTPALTH
     DQLVKKAKRA SSPYGAPITT PALINGQCAK KIKRASAPYG ALIATRARTN DPVVKTAERA
     SAPDGPTQRI PWASPSAFSV LNYALDRLNA VVEPHSSGIF KKLHADLQGL ALVATILRRA
     YQACRKTDLG RLVREDIHHH LSQCILTLTQ VHDDVVQLPY RWVPPWRRFG SVLYVWHWWT
     AVEEPEEVSS IRKLVNSQVK TLGSCLVSLK SKAAEGPKEA STSTKSDTSW MTHVPIKRST
     THCSTRTYAP ERHSNEACRM MVKVTEVTSP ERPAEPKEED TSCDESSPTE ERRRYSMPSN
     PRRRSRPVSP SASNGAIQEQ PLEEVAMEVT PEETQSTLMT EGDVLEARYL FRRMLIQLVV
     DNQTQASVVQ EDGAVVESPT DPWFVGEYME RFQQSPWYLR PNLNPSEIIM DHDGSIRAAT
     LEVLVERLTA HEETQAARRT DSPGVLDDDD LLVLGKIERF LQSRHLIGFT MASKVLLNLI
     ARATIRRGAR ERISSTSMPS PPAPIISKFS KTSGLLLDIH PLELARQLTL MESEFYQRIS
     SGELLRRAWK QGRRDNIFGL IEFSNKIVNW VVNIILSKED PRKRVALIKY FITVAERCRS
     LNNFASMVSI ISALNLPPVK RLKRTWGRIP PKETQLFSSC EKIIDSANNF TTYRQLMTSV
     RPPCVPFIGA YTSMLDFLRN VNHDNLIQSG GLINFRKRQK VWEVIMEATR FSNEPYNLQS
     VPFIQNYIRN SVDIRTRGDD YYWERSLMLE PRE
//
DBGET integrated database retrieval system