ID A8NQK2_COPC7 Unreviewed; 813 AA.
AC A8NQK2;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 2.
DT 24-JAN-2024, entry version 70.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
GN ORFNames=CC1G_03398 {ECO:0000313|EMBL:EAU86187.2};
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Psathyrellaceae; Coprinopsis.
OX NCBI_TaxID=240176 {ECO:0000313|EMBL:EAU86187.2, ECO:0000313|Proteomes:UP000001861};
RN [1] {ECO:0000313|EMBL:EAU86187.2, ECO:0000313|Proteomes:UP000001861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003
RC {ECO:0000313|Proteomes:UP000001861};
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA Burns C., Canback B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA Kues U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.J.,
RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAU86187.2}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACS02000008; EAU86187.2; -; Genomic_DNA.
DR RefSeq; XP_001835616.2; XM_001835564.2.
DR AlphaFoldDB; A8NQK2; -.
DR STRING; 240176.A8NQK2; -.
DR GeneID; 6012151; -.
DR KEGG; cci:CC1G_03398; -.
DR VEuPathDB; FungiDB:CC1G_03398; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_347141_0_0_1; -.
DR InParanoid; A8NQK2; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000001861; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF341; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001861}.
FT DOMAIN 580..812
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 326..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 813 AA; 92375 MW; 856D53235D1CD8A0 CRC64;
MPLFNRASNF TINGGTFNDF SREVVIHHHW HYDSHRTVQQ APIPVERHAS APITTPALTH
DQLVKKAKRA SSPYGAPITT PALINGQCAK KIKRASAPYG ALIATRARTN DPVVKTAERA
SAPDGPTQRI PWASPSAFSV LNYALDRLNA VVEPHSSGIF KKLHADLQGL ALVATILRRA
YQACRKTDLG RLVREDIHHH LSQCILTLTQ VHDDVVQLPY RWVPPWRRFG SVLYVWHWWT
AVEEPEEVSS IRKLVNSQVK TLGSCLVSLK SKAAEGPKEA STSTKSDTSW MTHVPIKRST
THCSTRTYAP ERHSNEACRM MVKVTEVTSP ERPAEPKEED TSCDESSPTE ERRRYSMPSN
PRRRSRPVSP SASNGAIQEQ PLEEVAMEVT PEETQSTLMT EGDVLEARYL FRRMLIQLVV
DNQTQASVVQ EDGAVVESPT DPWFVGEYME RFQQSPWYLR PNLNPSEIIM DHDGSIRAAT
LEVLVERLTA HEETQAARRT DSPGVLDDDD LLVLGKIERF LQSRHLIGFT MASKVLLNLI
ARATIRRGAR ERISSTSMPS PPAPIISKFS KTSGLLLDIH PLELARQLTL MESEFYQRIS
SGELLRRAWK QGRRDNIFGL IEFSNKIVNW VVNIILSKED PRKRVALIKY FITVAERCRS
LNNFASMVSI ISALNLPPVK RLKRTWGRIP PKETQLFSSC EKIIDSANNF TTYRQLMTSV
RPPCVPFIGA YTSMLDFLRN VNHDNLIQSG GLINFRKRQK VWEVIMEATR FSNEPYNLQS
VPFIQNYIRN SVDIRTRGDD YYWERSLMLE PRE
//