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Database: UniProt
Entry: A8PA43_COPC7
LinkDB: A8PA43_COPC7
Original site: A8PA43_COPC7 
ID   A8PA43_COPC7            Unreviewed;       848 AA.
AC   A8PA43;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   07-JUN-2017, entry version 37.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=CC1G_06089 {ECO:0000313|EMBL:EAU81878.1};
OS   Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC
OS   9003) (Inky cap fungus) (Hormographiella aspergillata).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Agaricomycetes; Agaricomycetidae; Agaricales; Psathyrellaceae;
OC   Coprinopsis.
OX   NCBI_TaxID=240176 {ECO:0000313|EMBL:EAU81878.1, ECO:0000313|Proteomes:UP000001861};
RN   [1] {ECO:0000313|EMBL:EAU81878.1, ECO:0000313|Proteomes:UP000001861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003
RC   {ECO:0000313|Proteomes:UP000001861};
RX   PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA   Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W.,
RA   Borodovsky M., Burns C., Canback B., Casselton L.A., Cheng C.K.,
RA   Deng J., Dietrich F.S., Fargo D.C., Farman M.L., Gathman A.C.,
RA   Goldberg J., Guigo R., Hoegger P.J., Hooker J.B., Huggins A.,
RA   James T.Y., Kamada T., Kilaru S., Kodira C., Kues U., Kupfer D.,
RA   Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.J., Mackey A.J.,
RA   Manning G., Martin F., Muraguchi H., Natvig D.O., Palmerini H.,
RA   Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA   Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA   Zolan M.E., Pukkila P.J.;
RT   "Insights into evolution of multicellular fungi from the assembled
RT   chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EAU81878.1}.
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DR   EMBL; AACS02000002; EAU81878.1; -; Genomic_DNA.
DR   RefSeq; XP_001839899.1; XM_001839847.2.
DR   STRING; 240176.XP_001839899.1; -.
DR   EnsemblFungi; EAU81878; EAU81878; CC1G_06089.
DR   GeneID; 6016522; -.
DR   KEGG; cci:CC1G_06089; -.
DR   EuPathDB; FungiDB:CC1G_06089; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; A8PA43; -.
DR   KO; K02154; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000001861; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001861};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001861};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    415    446       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    467    487       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    543    560       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    581    599       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    638    661       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      105    146       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   848 AA;  95600 MW;  DC165F6F76D3EE7F CRC64;
     MADEYPSLLR SERMSLVQLF VPTEVAHDTV HELGELGNVQ FKDLNPSVNP FQRSFVGEIR
     RIDEMGRRVR FFATQIEKEK DVVPVRPLID CAPVLTTGPR AAHTIDELDT TLAEHEARLT
     KMNESYQTLS ERTRELQEAK HVLKETAVFF DKAQNSRAEI RSSFDEASAP LLSHDDREAS
     YAPMSAGFDL EFVAGTIERS RVPTFERVLW RVLRGNLYMN HTDIAEPFVD PSTNEETFKN
     VFIIFAHGDA LLAKIRKVAE SMGATLFPID SNADKRSDAL REVTTRLEDL QTVLYNTGLT
     RRAELVKIGE GLRMWQDVVR KEKLIYETLN LFNYDVRRKT LIAEAWVPTR DITKIQLALR
     HATEGSGTSV PPILHELHTS KTPPTFHRTN KFTEGFQAIM DSYGISAYQE VNPGLFAVIT
     FPFLFAVMFG DIGHGAIIFF AALYMIAREK SLAKGGMGNS EIMGQFFFGR YIILLMGIFS
     IYTGFIYNDI FSKTLPIFKS GWKFANGSTT GEWTGSTYPF GLDPGWHGAS NALVFTNSYK
     MKMSIVLGVC HMTFALCLQV PNHFRFNRKS EIWTNFIPQM IFLQSIFGYL VLCILYKWTV
     DWSKSPVSPP SLLNMLITMF LEPGVVAPDK QLYPGQGFVQ LVLLGLAGIC VPWLLITKPY
     LAWRDMKKPR DEGYVSLGAS NELGTARDSG ENGFRQSEDD VLEGEEEGHG RAVLEHEEGD
     HEEHDFGDVV IHQIIHTIEF CLGCISHTAS YLRLWALSLA HAQLSEVLWD MTIAGFLNPQ
     GVTGWIALAI MGSMWFSLTV FILCLMEGLS AFLHALRLHW VEGNSKHFEG GGHQFVPLTF
     VEVASSED
//
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