ID A8PF74_COPC7 Unreviewed; 534 AA.
AC A8PF74;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Cyclohydrolase {ECO:0000313|EMBL:EAU81000.2};
GN ORFNames=CC1G_03176 {ECO:0000313|EMBL:EAU81000.2};
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Psathyrellaceae; Coprinopsis.
OX NCBI_TaxID=240176 {ECO:0000313|EMBL:EAU81000.2, ECO:0000313|Proteomes:UP000001861};
RN [1] {ECO:0000313|EMBL:EAU81000.2, ECO:0000313|Proteomes:UP000001861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003
RC {ECO:0000313|Proteomes:UP000001861};
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA Burns C., Canback B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA Kues U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.J.,
RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC -!- SIMILARITY: Belongs to the GTP cyclohydrolase II family.
CC {ECO:0000256|ARBA:ARBA00008131}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAU81000.2}.
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DR EMBL; AACS02000008; EAU81000.2; -; Genomic_DNA.
DR RefSeq; XP_001840947.2; XM_001840895.2.
DR AlphaFoldDB; A8PF74; -.
DR STRING; 240176.A8PF74; -.
DR GeneID; 6017603; -.
DR KEGG; cci:CC1G_03176; -.
DR VEuPathDB; FungiDB:CC1G_03176; -.
DR eggNOG; KOG1284; Eukaryota.
DR HOGENOM; CLU_029639_2_0_1; -.
DR InParanoid; A8PF74; -.
DR OMA; FQQLMPD; -.
DR OrthoDB; 46806at2759; -.
DR Proteomes; UP000001861; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:InterPro.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:InterPro.
DR CDD; cd00641; GTP_cyclohydro2; 1.
DR Gene3D; 3.40.50.10990; GTP cyclohydrolase II; 1.
DR InterPro; IPR022163; GTP_CH_N.
DR InterPro; IPR032677; GTP_cyclohydro_II.
DR InterPro; IPR000926; RibA.
DR InterPro; IPR036144; RibA-like_sf.
DR PANTHER; PTHR47259; -; 1.
DR PANTHER; PTHR47259:SF2; URACIL-REGULATED PROTEIN 1; 1.
DR Pfam; PF12471; GTP_CH_N; 1.
DR Pfam; PF00925; GTP_cyclohydro2; 1.
DR SUPFAM; SSF142695; RibA-like; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001861}.
FT DOMAIN 104..312
FT /note="GTP cyclohydrolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12471"
FT DOMAIN 348..485
FT /note="GTP cyclohydrolase II"
FT /evidence="ECO:0000259|Pfam:PF00925"
FT REGION 40..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 58644 MW; 46A88A5A448A3FEB CRC64;
MPVSEAILTQ ILARLESMQV SQQAMQAKLD SLAASQASIT PLEPKSPARS TPGLPSTADA
KNEEKKTGLQ EATVGAAVTS TTPARDALAQ MTDKEREKLL YPGRVNLTTY PDQHGIAPHP
LQWGAADPTT RGPVICSRLP SSIKQRNALG AHAGSYSIYR ALSIAMGALN PSHKPDYSQT
EPPINIPPQP SWSDPSKIVS FDPWGHLVPQ VFRKEMDELG LDVRPSIAIT KAHLKMSELD
EAARRGEMVI DGNIVLKSRP VRNEDGSENL SVDPGVEVNV GKAAIDPVWY LPGVAERFGI
SETLLRRALF EDTGGMYPEL ITRPDIKVFL PPIGGCTVYI FGNPAYMYDE TKELTLRVHD
ECNGSDVFGS DICTCKPYLV YAIEECIRGA QKGGVGVVAY FRKEGRALGE VTKYLVYNLR
KRGGDSADKY FKSTEMIAGV KDMRFQALMP DVLHWLGIRK VDRMVSMSDM KYDAIVKSGI
PILTRYDIPD HLIPPDSRVE IDAKIAAGYF SSGKQVTEAD LAKTVGRTWE EMEH
//
