ID A8PZ07_BRUMA Unreviewed; 907 AA.
AC A8PZ07;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=GCC2 and GCC3 family protein {ECO:0000313|EMBL:EDP32418.1};
GN ORFNames=Bm1_40755 {ECO:0000313|EMBL:EDP32418.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:EDP32418.1};
RN [1] {ECO:0000313|EMBL:EDP32418.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS239411; EDP32418.1; -; Genomic_DNA.
DR RefSeq; XP_001899610.1; XM_001899575.1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046:SF5; EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR Pfam; PF07699; Ephrin_rec_like; 4.
DR Pfam; PF02494; HYR; 1.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS50825; HYR; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 656..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 129..212
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT REGION 888..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..907
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 102651 MW; 3014608BD651C3CB CRC64;
MTRNQWQQFC FRRKKNGATE WIRNGEVVWQ RNWDVPPVNG SLRILLGSSE LFHGEISMVQ
LYSTALRNKQ INDSVQYCKQ WLQSIVTSGE TPLINWNQFS GVKHGNRNYP GICTLSDCLX
NPHRCNSTMD KVPPKVINCP SNIIVTSKNR LTVVNXSPSK SNEIFADNDI IQMSSNYNSG
DVFTWGKYHI VYIAEDKAGN IETCQFDLVI ATMNCSNPKK TDGINFTIRN IHSENVRKVA
FVECKSNYVS IHPVTDFYFC DLMGYWTRWS HGINFYFPSC LKYRAPLQQL SGLIIVTANC
SEFDLYKKNL TAVILTANKQ FNHFCTTPNC TKELKMWSNS SCDNQVLRHP NEAAQNIYLY
YSITVSTTRK SIKPAVTENL NKVFGNKIGE TNTSWQCPSK NYPAQIFGSD TRSCVKCPPG
MYCVNDRCMP CPENTFKKNA GCKQCIPCPN NTITGPIIKD IGYQSIFDCY TNCSAGYHYS
IQDGSCVKCP KGMYQDRPGQ LRCNACPESR STPKRGSVHI SNCTITCGAG MSMSSHSQCV
KCAKGKYRQE NSTEARCTPC PDYFTTPDNG SISQNNCTVL NCPPGTYINL SLPSECFLCP
RDHYQEKSNQ TECRHCMKPL ITLGMGSVHP RQCMKPLFWS SAGSDVDISK YFSSNLWPNF
GFVGIIGAIA FLALLYFQRQ RMRSLFYKIR GAQLKHMATL NYYRDSSFTY PIVTVTPTDT
SATPDFSEDR VPKNRETQEM VEIYQEIYDG LHSMAEGTSY VSNSELTSSQ SLRPISRVRL
EVDTTLRAEF CGNPKALGMD SSGFPIDSAD YENADQCNSI VPKNYGQDSE ASDEENQISS
FKRRLDAYRN WNLRIPLDEI YMEPTEYKLF LSKANDISVE KTSGILNEEN KNNENKNEES
DDEVCVI
//
