ID   A8QWG6_ECOLX            Unreviewed;       998 AA.
AC   A8QWG6;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   SubName: Full=Enterohemolysin {ECO:0000313|EMBL:ABQ02441.1};
GN   Name=ehxA {ECO:0000313|EMBL:ABQ02441.1};
OS   Escherichia coli.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562 {ECO:0000313|EMBL:ABQ02441.1};
RN   [1] {ECO:0000313|EMBL:ABQ02441.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AGR119 {ECO:0000313|EMBL:ABQ02441.1};
RX   PubMed=17720842; DOI=10.1128/AEM.00316-07;
RA   Cookson A.L., Bennett J., Thomson-Carter F., Attwood G.T.;
RT   "Molecular subtyping and genetic analysis of the enterohemolysin gene
RT   (ehxA) from Shiga toxin-producing escherichia coli and atypical
RT   enteropathogenic E. coli.";
RL   Appl. Environ. Microbiol. 73:6360-6369(2007).
RN   [2] {ECO:0000313|EMBL:ABQ02441.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AGR119 {ECO:0000313|EMBL:ABQ02441.1};
RA   Cookson A., Bennett J., Thomson-Carter F., Attwood G.;
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.
CC       {ECO:0000256|ARBA:ARBA00005918}.
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DR   EMBL; EF204921; ABQ02441.1; -; Genomic_DNA.
DR   RefSeq; WP_000217740.1; NZ_WJGB01000083.1.
DR   PATRIC; fig|562.6984.peg.5363; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0015267; F:channel activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   Gene3D; 2.150.10.10; Serralysin-like metalloprotease, C-terminal; 2.
DR   InterPro; IPR018511; Hemolysin-typ_Ca-bd_CS.
DR   InterPro; IPR001343; Hemolysn_Ca-bd.
DR   InterPro; IPR013550; RTX_C.
DR   InterPro; IPR018504; RTX_pore_form.
DR   InterPro; IPR003995; RTX_toxin_determinant-A.
DR   InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR   NCBIfam; NF033203; entero_EhxA; 1.
DR   NCBIfam; NF033943; RTX_toxin; 1.
DR   PANTHER; PTHR38340; S-LAYER PROTEIN; 1.
DR   PANTHER; PTHR38340:SF1; S-LAYER PROTEIN; 1.
DR   Pfam; PF00353; HemolysinCabind; 3.
DR   Pfam; PF02382; RTX; 1.
DR   Pfam; PF08339; RTX_C; 1.
DR   PRINTS; PR00313; CABNDNGRPT.
DR   PRINTS; PR01488; RTXTOXINA.
DR   SUPFAM; SSF51120; beta-Roll; 1.
DR   PROSITE; PS00330; HEMOLYSIN_CALCIUM; 4.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Toxin {ECO:0000256|ARBA:ARBA00022656};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT   DOMAIN          278..584
FT                   /note="RTX pore-forming"
FT                   /evidence="ECO:0000259|Pfam:PF02382"
FT   DOMAIN          854..998
FT                   /note="RTX C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08339"
SQ   SEQUENCE   998 AA;  107111 MW;  CA5735AD070388F5 CRC64;
     MTVNKIKNIF NNATLTTKSA FNTASSSVRS AGKKLILLIP DNYEAQGVGI NELVKAADEL
     GIEIHRTERD DTAIANQFFG AAEKVVGLTE RGVAIFAPQL DKLLQKYQKV GSKIGGTAEN
     VGNNLGKAGT VLSALQNFTG IALSGMALDE LLRKQREGED ISQNDIAKSS IELINQLVDT
     VSSINSTVDS FSEQLNQLGS FLSSKPRLSS VGGKLQNLPD LGSLGDGLDV VSGILSAVSA
     SFILGNSDAH TGTKAAAGIE LTTQVLGNVG KAVSQYILAQ RMAQGLSTTA ASAGLITSAV
     MLAISPLSFL AAADKFERAK QLESYSERFK KLNYEGDALL AAFHKETGAI DAALTTINTV
     LSSVSAGVSA ASSASLIGAP ISMLVSALTG TISGILEASK QAMFEHVAEK FAARINEWEK
     EHGKNYFENG YDARHAAFLE DSLSLLADFS RQHAVERAVA ITQQHWDEKI GELAGITRNA
     DRSQSGKAYI NYLENGGLLE AQPKEFTQQV FDPQKGTIDL STGNVSSVLT FITPTFTPGE
     EVRERKQSGK YEYMTSLIVN GKDTWSVKGI KNHKGVYDYS KLIQFVEKNN KHYQARIISE
     LGDKDDVVYS GAGSSEVFAG EGHDTVSYNK TDVGKLTIDA TGASKPGEYI VSKNMYGDVK
     VLQEVVKEQE VSVGKRTEKI QYRDFEFRTG GIPYDVIDNL HSVEELIGGK HDDEFKGGKF
     NDIFHGADGN DYIEGNYGND RLYGDDGDDY ISGGQGDDQL FGGSGNDKLS GGDGNNYLTG
     GSGNDELQAH GAYNILSGGT GDDKLYGGGG IDLLDGGEGN DYLNGGFGND IYVYRQNYGH
     HTIADEGGKG DRLHLSDISF DDIAFKRVGN DLIMNKAING VLSFNESNDV NGITFKNWFA
     KDASGADNHL VEVITDKDGR EIKVDKIPHN NNERSGYIKA SNIASEKNMV NITSVANDIN
     KIISSVSGFD SGDERLASLY NLSLHQNNTH STTLTTTV
//