ID A8SGD5_9FIRM Unreviewed; 439 AA.
AC A8SGD5;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=THUMP domain-containing protein {ECO:0000259|PROSITE:PS51165};
GN ORFNames=FAEPRAM212_03032 {ECO:0000313|EMBL:EDP20239.1};
OS Faecalibacterium prausnitzii M21/2.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Faecalibacterium.
OX NCBI_TaxID=411485 {ECO:0000313|EMBL:EDP20239.1, ECO:0000313|Proteomes:UP000005945};
RN [1] {ECO:0000313|EMBL:EDP20239.1, ECO:0000313|Proteomes:UP000005945}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M21/2 {ECO:0000313|EMBL:EDP20239.1,
RC ECO:0000313|Proteomes:UP000005945};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Faecalibacterium prausnitzii M21/2.";
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDP20239.1, ECO:0000313|Proteomes:UP000005945}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M21/2 {ECO:0000313|EMBL:EDP20239.1,
RC ECO:0000313|Proteomes:UP000005945};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Thiruvilangam P., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDP20239.1}.
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DR EMBL; ABED02000029; EDP20239.1; -; Genomic_DNA.
DR AlphaFoldDB; A8SGD5; -.
DR HOGENOM; CLU_032119_3_1_9; -.
DR Proteomes; UP000005945; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR PANTHER; PTHR47313; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K/L; 1.
DR PANTHER; PTHR47313:SF1; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K_L; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51165; THUMP; 1.
DR PROSITE; PS01261; UPF0020; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 87..197
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
SQ SEQUENCE 439 AA; 48121 MW; FE0DFF1B7241F02F CRC64;
MPPAAAVAAE LSYQLGSQGT QAGLSPVGQV CFFGTEQKGT TMPAKFELIA PCFFGCESTA
KFELTRIGAE NIRVEDGRLS FCGGAEMIAA ANLNLRTVER VMLLLARYKA TTFDELFDGV
YSIPWEEFLP ADAAFPVTGS SLNSQLTSIP ACQSVIKKAV VKRLMKGHRT TVLPESGVEY
KVRFMLRKNV CEIMLDTTGE GLHKRGYRRN AMEAPLRETL AATIADLGRV RRDSLVEDPF
CGSGTLLIEA AQKAMNIAPG LKRRFAAERY SFVPAALWAE QRQKALAESK LDVGFEAFGY
DIDPAAVAQA NVNAKLAGVE NRCHFEVADV ATFAAKPEAI VLTNPPYGER LGTIEGAAKL
ARTLGQQMEA SPCAGLYAIT ADMDFELHYG KRANKRRKMY NGMIPCQLYM YYNAPKTEKM
AKPMPKSGFD GKRTHFEKK
//
