ID A8SZR3_9VIBR Unreviewed; 605 AA.
AC A8SZR3;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Dihydroorotase {ECO:0000313|EMBL:EDP60499.1};
DE EC=3.5.2.3 {ECO:0000313|EMBL:EDP60499.1};
GN ORFNames=AND4_06264 {ECO:0000313|EMBL:EDP60499.1};
OS Vibrio sp. AND4.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=314289 {ECO:0000313|EMBL:EDP60499.1, ECO:0000313|Proteomes:UP000005159};
RN [1] {ECO:0000313|EMBL:EDP60499.1, ECO:0000313|Proteomes:UP000005159}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AND4 {ECO:0000313|EMBL:EDP60499.1,
RC ECO:0000313|Proteomes:UP000005159};
RX PubMed=20436956; DOI=10.1371/journal.pbio.1000358;
RA Gomez-Consarnau L., Akram N., Lindell K., Pedersen A., Neutze R.,
RA Milton D.L., Gonzalez J.M., Pinhassi J.;
RT "Proteorhodopsin phototrophy promotes survival of marine bacteria during
RT starvation.";
RL PLoS Biol. 8:E1000358-E1000358(2010).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDP60499.1}.
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DR EMBL; ABGR01000001; EDP60499.1; -; Genomic_DNA.
DR RefSeq; WP_009840957.1; NZ_ABGR01000001.1.
DR AlphaFoldDB; A8SZR3; -.
DR OrthoDB; 581532at2; -.
DR Proteomes; UP000005159; Unassembled WGS sequence.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0004151; F:dihydroorotase activity; IEA:UniProtKB-EC.
DR GO; GO:0030151; F:molybdenum ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR CDD; cd00207; fer2; 1.
DR CDD; cd06215; FNR_iron_sulfur_binding_1; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR006058; 2Fe2S_fd_BS.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR008333; Cbr1-like_FAD-bd_dom.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR005302; MoCF_Sase_C.
DR InterPro; IPR005303; MOCOS_middle.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR011037; Pyrv_Knase-like_insert_dom_sf.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR47354; NADH OXIDOREDUCTASE HCR; 1.
DR PANTHER; PTHR47354:SF6; NADH OXIDOREDUCTASE HCR; 1.
DR Pfam; PF00970; FAD_binding_6; 1.
DR Pfam; PF00111; Fer2; 1.
DR Pfam; PF03473; MOSC; 1.
DR Pfam; PF03476; MOSC_N; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00406; CYTB5RDTASE.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF141673; MOSC N-terminal domain-like; 1.
DR SUPFAM; SSF50800; PK beta-barrel domain-like; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS00197; 2FE2S_FER_1; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS51340; MOSC; 1.
PE 4: Predicted;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW Hydrolase {ECO:0000313|EMBL:EDP60499.1};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Membrane {ECO:0000256|ARBA:ARBA00022692};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022714};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT DOMAIN 113..264
FT /note="MOSC"
FT /evidence="ECO:0000259|PROSITE:PS51340"
FT DOMAIN 277..380
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
FT DOMAIN 521..605
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
SQ SEQUENCE 605 AA; 67487 MW; FEDC02B0C6C46000 CRC64;
MSQSVLSQIN VFPVKSVGGV SLSSAWVEKQ GLSFDRRFMI ATSDGSMVTA RKFPQMVTIK
SALLPDGVVF TSLGEEPLTI RYQDFKMQEA PATVWKDSFT AYTTTDEADD WFSKVLGLRV
ELLFTGEQSN RVRDKLGHNV SFADGYPVLV ISEASLEELN RRSAEQHSMD QFRTNLVVSD
TTPFEEDTWK RIRIGEVEFE SVKPCERCIL TTVNTQRGTF RESKEPLKTL QEFRANERGG
VFFGQNLVAL NQGIIRSGDH VEVLEYKEPE FYPDNSPKRM TLTCVEREEI ARDFVTLWLE
PREGQLPTYL PGQHLPIVVE VDGQTIGRRY TLSSSPSRPG RYAISVKRVS GGRVSNALLD
NLQIGDVLEA ETPDGQFHLK AHAVQPLLLM SAGSGVTPML SMVRYLADHN QLDDVVFYHQ
CSSEIDIPCK DELNELKRQN PGLDVKICLT QPSIDWFGLK GRVSLSHIKQ IKDVEHRQVF
VCGPDGFMQK AKNLLLKKGL PEGNYHQEAF GVAMAAAKPE KSVEIEFNGV KWMGNNQQTL
LEQVENAGKH ITNSCRAGLC GACEVQLESG LVDHPDLPAL SAEERAMGKV LACCAIPQTD
VTLKD
//
