ID   A8TMK4_9PROT            Unreviewed;       503 AA.
AC   A8TMK4;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:EDP65802.1};
GN   ORFNames=BAL199_03219 {ECO:0000313|EMBL:EDP65802.1};
OS   alpha proteobacterium BAL199.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria.
OX   NCBI_TaxID=331869 {ECO:0000313|EMBL:EDP65802.1, ECO:0000313|Proteomes:UP000003417};
RN   [1] {ECO:0000313|EMBL:EDP65802.1, ECO:0000313|Proteomes:UP000003417}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BAL199 {ECO:0000313|EMBL:EDP65802.1,
RC   ECO:0000313|Proteomes:UP000003417};
RA   Hagstrom A., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA   Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDP65802.1}.
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DR   EMBL; ABHC01000003; EDP65802.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8TMK4; -.
DR   STRING; 331869.BAL199_03219; -.
DR   eggNOG; COG1250; Bacteria.
DR   OrthoDB; 9771883at2; -.
DR   Proteomes; UP000003417; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000003417}.
FT   DOMAIN          11..188
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          191..288
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          413..496
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   503 AA;  53135 MW;  C9BCDF9697D95C5E CRC64;
     MIDPNAKDLV VGVVGCGAMG QGIIQVALQG GLRVVAYDAR AGGAAAGRDA VLARLDRLVE
     KQTLTTDAAA AMREALSVTD DIADLAPAGV VVEAVFEDIE VKRELFGKLE AVVAEDAILA
     SNTSSLPIGS IARSCKHPGR VAGLHFFNPV PLMRLVEVIK GPATDPAVVD ALVTIGTRFG
     RTPVVVKDSP GFLVNMGGRA FTTEGLHLQH EGVATPAQVD AVMRDCGHFR MGPFQLMDLT
     GIDVNYPVSM IVFEQFLNDP RLRTTPHHRA LFDAGRFGRK TGQGHYRYDA KGTVIDPPSA
     DHATDAAPAS VVHVATPNDQ ALDELLDRAG LSSRADDGAM PIVAALYGED ASGFCARTGT
     DPRRLVAVDT TGDTSKRVTL MTAPSADPAH RDAVAAAFVK AGVAPTVIKD SPGFILQRMR
     AMIANLGCEM AQIGLATPAD IDLAMKLGLN YPLGPLEIAK EMGVARTHAI IAAIHDATRD
     PRYRPSLWLR RRALLGLPVH ATG
//