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Database: UniProt
Entry: A8VR99_PSEAI
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Original site: A8VR99_PSEAI 
ID   A8VR99_PSEAI            Unreviewed;       265 AA.
AC   A8VR99;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE            EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN   Name=aadA13 {ECO:0000313|EMBL:ABW91178.1};
GN   ORFNames=JTL35_013705 {ECO:0000313|EMBL:MDL5563485.1};
OS   Pseudomonas aeruginosa.
OG   Plasmid pPA26 {ECO:0000313|EMBL:ABW91178.1}.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=287 {ECO:0000313|EMBL:ABW91178.1};
RN   [1] {ECO:0000313|EMBL:ABW91178.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PA26 {ECO:0000313|EMBL:ABW91178.1};
RC   PLASMID=pPA26 {ECO:0000313|EMBL:ABW91178.1};
RX   PubMed=19107398; DOI=10.1007/s12275-008-0021-6;
RA   Wu Y., Li H., Li J., Huang Z.H.;
RT   "Detection of Pseudomonas aeruginosa carried a new array of gene cassettes
RT   within class 1 integron isolated from a teaching hospital in Nanjing,
RT   China.";
RL   J. Microbiol. 46:687-691(2008).
RN   [2] {ECO:0000313|EMBL:ACF06121.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=82114 {ECO:0000313|EMBL:ACF06121.1};
RA   Ratkai C., Quinteira S., Grosso F., Nagy E., Peixe L.;
RT   "Characterization of class I integrons from Pseudomonas aeruginosa clinical
RT   isolates from Hungary.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ACJ64670.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=06-151 {ECO:0000313|EMBL:ACJ64670.1};
RX   PubMed=18946702; DOI=10.1007/s00284-008-9285-7;
RA   Libisch B., Balogh B., Fuzi M.;
RT   "Identification of two multidrug-resistant Pseudomonas aeruginosa clonal
RT   lineages with a countrywide distribution in Hungary.";
RL   Curr. Microbiol. 58:111-116(2009).
RN   [4] {ECO:0000313|EMBL:AFQ94781.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ODM-08 {ECO:0000313|EMBL:AFQ94781.1};
RX   PubMed=24143920;
RA   Odumosu B.T., Adeniyi B.A., Chandra R.;
RT   "Analysis of integrons and associated gene cassettes in clinical isolates
RT   of multidrug resistant Pseudomonas aeruginosa from Southwest Nigeria.";
RL   Ann. Clin. Microbiol. Antimicrob. 12:29-29(2013).
RN   [5] {ECO:0000313|EMBL:AIG62112.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=4019-1 {ECO:0000313|EMBL:AIG62112.1}, 4044-1
RC   {ECO:0000313|EMBL:AIG62123.1}, and EMA-1
RC   {ECO:0000313|EMBL:AIG62126.1};
RA   Siebor E., Neuwirth C.;
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:MDL5563485.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NMI2426/06 {ECO:0000313|EMBL:MDL5563485.1};
RA   Urbanowicz P., Izdebski R., Biedrzycka M., Gniadkowski M.;
RT   "MBL-encoding genomic islands in Pseudomonas spp. in Poland.";
RL   Submitted (JUN-2023) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC         Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC         Evidence={ECO:0000256|ARBA:ARBA00001672,
CC         ECO:0000256|PIRNR:PIRNR000819};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC         Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC         Evidence={ECO:0000256|ARBA:ARBA00035070,
CC         ECO:0000256|PIRNR:PIRNR000819};
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DR   EMBL; EU182575; ABW91178.1; -; Genomic_DNA.
DR   EMBL; EU746499; ACF06121.1; -; Genomic_DNA.
DR   EMBL; EU863269; ACJ64670.1; -; Genomic_DNA.
DR   EMBL; JX195556; AFQ94781.1; -; Genomic_DNA.
DR   EMBL; KF468743; AIG62112.1; -; Genomic_DNA.
DR   EMBL; KF468748; AIG62123.1; -; Genomic_DNA.
DR   EMBL; KF468749; AIG62126.1; -; Genomic_DNA.
DR   EMBL; JAFFYS020000001; MDL5563485.1; -; Genomic_DNA.
DR   RefSeq; WP_001424636.1; NZ_VMNS01000014.1.
DR   SMR; A8VR99; -.
DR   KEGG; ag:AFQ94781; -.
DR   Proteomes; UP000712497; Unassembled WGS sequence.
DR   GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR   GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd05403; NT_KNTase_like; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR024172; AadA/Aad9.
DR   InterPro; IPR025184; AadA_C.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   Pfam; PF13427; AadA_C; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE   4: Predicted;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW   ECO:0000256|PIRNR:PIRNR000819};
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW   Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819,
KW   ECO:0000313|EMBL:AFQ94781.1}; Plasmid {ECO:0000313|EMBL:ABW91178.1};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:ACF06121.1}.
FT   DOMAIN          28..96
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          152..255
FT                   /note="Adenylyltransferase AadA C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13427"
SQ   SEQUENCE   265 AA;  29724 MW;  DD421C6518613654 CRC64;
     MRDSVTAEIS TQLSKVLSVI EHHLEPTLLA VHLYGSAVDG GLKPYSDIDL LVTVTARLDD
     TTRRALFNDL LEVSAFPGES EILRAIEVTI VVHEDIMPWR YPAKRELQFG EWQRNDILAG
     IFEPATIDID LAILLTKARE HSVALVGPAA EELFDPVPEQ DLIKALNETL KLWNSQPDWA
     GDERNVVLTL SRIWYSAATG KIAPKDVAAN WAMEHLPAQH QSVLLEARQA YLGQEEDRSV
     LRADKLEEFI HFMKSEITKV LGNDV
//
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