ID A8VR99_PSEAI Unreviewed; 265 AA.
AC A8VR99;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN Name=aadA13 {ECO:0000313|EMBL:ABW91178.1};
GN ORFNames=JTL35_013705 {ECO:0000313|EMBL:MDL5563485.1};
OS Pseudomonas aeruginosa.
OG Plasmid pPA26 {ECO:0000313|EMBL:ABW91178.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=287 {ECO:0000313|EMBL:ABW91178.1};
RN [1] {ECO:0000313|EMBL:ABW91178.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PA26 {ECO:0000313|EMBL:ABW91178.1};
RC PLASMID=pPA26 {ECO:0000313|EMBL:ABW91178.1};
RX PubMed=19107398; DOI=10.1007/s12275-008-0021-6;
RA Wu Y., Li H., Li J., Huang Z.H.;
RT "Detection of Pseudomonas aeruginosa carried a new array of gene cassettes
RT within class 1 integron isolated from a teaching hospital in Nanjing,
RT China.";
RL J. Microbiol. 46:687-691(2008).
RN [2] {ECO:0000313|EMBL:ACF06121.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=82114 {ECO:0000313|EMBL:ACF06121.1};
RA Ratkai C., Quinteira S., Grosso F., Nagy E., Peixe L.;
RT "Characterization of class I integrons from Pseudomonas aeruginosa clinical
RT isolates from Hungary.";
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ACJ64670.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=06-151 {ECO:0000313|EMBL:ACJ64670.1};
RX PubMed=18946702; DOI=10.1007/s00284-008-9285-7;
RA Libisch B., Balogh B., Fuzi M.;
RT "Identification of two multidrug-resistant Pseudomonas aeruginosa clonal
RT lineages with a countrywide distribution in Hungary.";
RL Curr. Microbiol. 58:111-116(2009).
RN [4] {ECO:0000313|EMBL:AFQ94781.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ODM-08 {ECO:0000313|EMBL:AFQ94781.1};
RX PubMed=24143920;
RA Odumosu B.T., Adeniyi B.A., Chandra R.;
RT "Analysis of integrons and associated gene cassettes in clinical isolates
RT of multidrug resistant Pseudomonas aeruginosa from Southwest Nigeria.";
RL Ann. Clin. Microbiol. Antimicrob. 12:29-29(2013).
RN [5] {ECO:0000313|EMBL:AIG62112.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=4019-1 {ECO:0000313|EMBL:AIG62112.1}, 4044-1
RC {ECO:0000313|EMBL:AIG62123.1}, and EMA-1
RC {ECO:0000313|EMBL:AIG62126.1};
RA Siebor E., Neuwirth C.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:MDL5563485.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NMI2426/06 {ECO:0000313|EMBL:MDL5563485.1};
RA Urbanowicz P., Izdebski R., Biedrzycka M., Gniadkowski M.;
RT "MBL-encoding genomic islands in Pseudomonas spp. in Poland.";
RL Submitted (JUN-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672,
CC ECO:0000256|PIRNR:PIRNR000819};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070,
CC ECO:0000256|PIRNR:PIRNR000819};
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DR EMBL; EU182575; ABW91178.1; -; Genomic_DNA.
DR EMBL; EU746499; ACF06121.1; -; Genomic_DNA.
DR EMBL; EU863269; ACJ64670.1; -; Genomic_DNA.
DR EMBL; JX195556; AFQ94781.1; -; Genomic_DNA.
DR EMBL; KF468743; AIG62112.1; -; Genomic_DNA.
DR EMBL; KF468748; AIG62123.1; -; Genomic_DNA.
DR EMBL; KF468749; AIG62126.1; -; Genomic_DNA.
DR EMBL; JAFFYS020000001; MDL5563485.1; -; Genomic_DNA.
DR RefSeq; WP_001424636.1; NZ_VMNS01000014.1.
DR SMR; A8VR99; -.
DR KEGG; ag:AFQ94781; -.
DR Proteomes; UP000712497; Unassembled WGS sequence.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|PIRNR:PIRNR000819};
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819,
KW ECO:0000313|EMBL:AFQ94781.1}; Plasmid {ECO:0000313|EMBL:ABW91178.1};
KW Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:ACF06121.1}.
FT DOMAIN 28..96
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 152..255
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 265 AA; 29724 MW; DD421C6518613654 CRC64;
MRDSVTAEIS TQLSKVLSVI EHHLEPTLLA VHLYGSAVDG GLKPYSDIDL LVTVTARLDD
TTRRALFNDL LEVSAFPGES EILRAIEVTI VVHEDIMPWR YPAKRELQFG EWQRNDILAG
IFEPATIDID LAILLTKARE HSVALVGPAA EELFDPVPEQ DLIKALNETL KLWNSQPDWA
GDERNVVLTL SRIWYSAATG KIAPKDVAAN WAMEHLPAQH QSVLLEARQA YLGQEEDRSV
LRADKLEEFI HFMKSEITKV LGNDV
//