ID A8W0Z4_TRYCR Unreviewed; 143 AA.
AC A8W0Z4;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Leucine aminopeptidase {ECO:0000313|EMBL:ABW38346.1};
DE Flags: Fragment;
GN Name=Lap {ECO:0000313|EMBL:ABW38346.1};
OS Trypanosoma cruzi.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=5693 {ECO:0000313|EMBL:ABW38346.1};
RN [1] {ECO:0000313|EMBL:ABW38346.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CLBrener {ECO:0000313|EMBL:ABW38356.1}, M5631cl5
RC {ECO:0000313|EMBL:ABW38346.1}, M6241cl6 {ECO:0000313|EMBL:ABW38347.1},
RC P63cl1 {ECO:0000313|EMBL:ABW38358.1}, Tulacl2
RC {ECO:0000313|EMBL:ABW38360.1}, and X109/2
RC {ECO:0000313|EMBL:ABW38348.1};
RX PubMed=19389398; DOI=10.1016/j.exppara.2009.04.008;
RA Subileau M., Barnabe C., Douzery E.J., Diosque P., Tibayrenc M.;
RT "Trypanosoma cruzi: new insights on ecophylogeny and hybridization by
RT multigene sequencing of three nuclear and one maxicircle genes.";
RL Exp. Parasitol. 122:328-337(2009).
CC -!- SIMILARITY: Belongs to the peptidase M17 family.
CC {ECO:0000256|ARBA:ARBA00009528}.
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DR EMBL; EU186445; ABW38346.1; -; Genomic_DNA.
DR EMBL; EU186446; ABW38347.1; -; Genomic_DNA.
DR EMBL; EU186447; ABW38348.1; -; Genomic_DNA.
DR EMBL; EU186455; ABW38356.1; -; Genomic_DNA.
DR EMBL; EU186457; ABW38358.1; -; Genomic_DNA.
DR EMBL; EU186459; ABW38360.1; -; Genomic_DNA.
DR AlphaFoldDB; A8W0Z4; -.
DR MEROPS; M17.014; -.
DR VEuPathDB; TriTrypDB:BCY84_14603; -.
DR VEuPathDB; TriTrypDB:C3747_43g108; -.
DR VEuPathDB; TriTrypDB:C4B63_2g450; -.
DR VEuPathDB; TriTrypDB:Tc_MARK_515; -.
DR VEuPathDB; TriTrypDB:TcBrA4_0058400; -.
DR VEuPathDB; TriTrypDB:TcCL_NonESM02211; -.
DR VEuPathDB; TriTrypDB:TcCLB.504153.140; -.
DR VEuPathDB; TriTrypDB:TcCLB.508799.240; -.
DR VEuPathDB; TriTrypDB:TCDM_01548; -.
DR VEuPathDB; TriTrypDB:TcG_04108; -.
DR VEuPathDB; TriTrypDB:TCSYLVIO_001670; -.
DR VEuPathDB; TriTrypDB:TcYC6_0043810; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR011356; Leucine_aapep/pepB.
DR InterPro; IPR000819; Peptidase_M17_C.
DR PANTHER; PTHR11963:SF4; AMINOPEPTIDASE NPEPL1-RELATED; 1.
DR PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR Pfam; PF00883; Peptidase_M17; 1.
DR PRINTS; PR00481; LAMNOPPTDASE.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00631; CYTOSOL_AP; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW ECO:0000313|EMBL:ABW38346.1}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 28..35
FT /note="Cytosol aminopeptidase"
FT /evidence="ECO:0000259|PROSITE:PS00631"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABW38346.1"
FT NON_TER 143
FT /evidence="ECO:0000313|EMBL:ABW38346.1"
SQ SEQUENCE 143 AA; 15464 MW; DD3F0AE69AB2BE31 CRC64;
AENAIGPDAY RNDDILTLKS GKTVEVNNTD AEGRLVLGDG VFHATHEISF KPDVLVDMAT
LTGAQGIATG HRHAGIFVND EEEEFSFLKA GRVSGETCFP VLYCPEYHVT EFRSPVADMR
NSVKQVNNAS VSCAGHFVAN HLS
//
