ID A8WC95_PIG Unreviewed; 1212 AA.
AC A8WC95;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 24-JAN-2024, entry version 85.
DE SubName: Full=Euchromatic histone-lysine N-methyltransferase 2 {ECO:0000313|EMBL:ABX10189.1};
GN Name=Ehmt2 {ECO:0000313|EMBL:ABX10189.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:ABX10189.1};
RN [1] {ECO:0000313|EMBL:ABX10189.1}
RP NUCLEOTIDE SEQUENCE.
RA Liu L., Jiang S.;
RT "Cloning, characterization and polymorphism of porcine G9a gene.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; EU219914; ABX10189.1; -; mRNA.
DR AlphaFoldDB; A8WC95; -.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd20905; EHMT_ZBD; 1.
DR CDD; cd10533; SET_EHMT2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043550; EHMT1/EHMT2.
DR InterPro; IPR047762; EHMT_CRR.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR038034; SET_EHMT2.
DR PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR PANTHER; PTHR46307:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF21533; EHMT1-2_CRR; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Methyltransferase {ECO:0000313|EMBL:ABX10189.1};
KW Transferase {ECO:0000313|EMBL:ABX10189.1}.
FT REPEAT 686..718
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 719..751
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 752..776
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 786..818
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 852..884
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 974..1037
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 1040..1157
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..330
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..367
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1212 AA; 132443 MW; AC086009FB7159E2 CRC64;
MAAAAGAAAA AAAEGEAPAE MGALVLEKEP RGATERVHGS LGDTPRSEEA LPKANPDSLE
PAGPSSPASV TVTVGDEGAD TPIGATPLIG DEPENLEGDG DLHGGRILLG HATKSFPSSP
SKGGACPSRA KMSMTGAGKS PPSVQSLAMR LLSMPGAQGA ATAAIPEPPP ATASPEGQPK
VHRARKTMSK PGNGQPPVPE KRPPEVQHFR MSDDVHSLGK VTSDVAKRRK LNSGGGLSEE
LGSARGSGDV SLEKGDPGSL EEWETVVGED FSLYYDSYSV DERVDSDSKS EVEALAEQLS
EEEEEEEEEE EEEEEEEEEE EEEEEDEESG NQSDRSGSSG RRKAKRKWRK DSPWVKPSRK
RRKREPPRAK EPRGVNGVGS SGPSEYMEVP LGSLELPSEG TLSPNHAGVS NDTSSLETER
GFEELPLCNC RMEAPKIDRI SERAGHKCMA TESVDGELSG CNAAILKRET MRPSSRVALM
VLCETHRARM VKHHCCPGCG YFCTAGTFLE CHPDFRVAHR FHKACVSQLN GMVFCPHCGE
DASEAQEVTI PRGDGVTPPA GTAAPAPPPL AQDAPGRADT SQPSARMRGH GEPRRPPCDP
LADTIDSSGP SLTLPSGGCL SAVGLPPGPG REALEKALVI QESERRKKLR FHPRQLYLSV
KQGELQKVIL MLLDNLDPNF QSDQQSKRTP LHAAAQKGSV EICHVLLQAG ANINAVDKQQ
RTPLMEAVVN NHLEVARYMV QRGGCVYSKE EDGSTCLHHA AKIGNLEMVS LLLSTGQVDV
NAQDSGGWTP IIWAAEHKHI EVIRMLLTRG ADVTLTDNEE NICLHWASFT GSAAIAEVLL
NARCDLHAVN YHGDTPLHIA ARESYHDCVL LFLSRGANPE LRNKEGDTAW DLTPERSDVW
FALQLNRKLR LGVGNRAIRT EKIICRDVAR GYENVPIPCV NGVDSEPCPE DYKYISENCE
TSTMNIDRNI THLQHCTCVD DCSSSNCLCG QLSIRCWYDK DGRLLQEFNK IEPPLIFECN
QACSCWRNCK NRVVQSGIKV RLQLYRTAKM GWGVRALQTI PQGTFICEYV GELISDAEAD
AREDDSYLFD LDNKDGEVYC IDARYYGNIS RFINHLCDPN IIPVRVFMLH QDLRFPRIAF
FSSRDIRTGE ELGFDYGDRF WDIKSKYFTC QCGSEKCKHS AEAIALEQSR LARLDPHPEL
LPELSSLPPV NP
//
